Izitatimende zinqunywe ezimweni lapho ukudla nokuzivocavoca okwanele ukwehlisa amazinga akho e- cholesterol . Ngenxa yokuthi bayakwazi ukuthinta zonke izici zephrofayili yakho ye-lipid, i-statins ingenye yemithi evamile yokunciphisa i-lipid. Nakuba ungase ucabange ngamazinga aphezulu e-cholesterol ne-triglyceride njengento okumele ukhathazeke ngayo njengoba ukhula, ungaba namazinga aphezulu e-cholesterol esemncane, futhi-ngisho naku-20s, 30s, no-40s, okuvame ukuzungeze isikhathi abesifazane abaningi baqala ukuba nezingane.
Ukuba namazinga aphezulu e-cholesterol angasho ukuthi ungafakwa emithini ye-cholesterol ehlisa phansi njengesimiso.
Kukhona okwamanje izitembu eziyisikhombisa ezimakethe zase-US:
- I-Crestor (i-rosuvastatin)
- I-Lescol (i-fluvastatin)
- I-Lipitor (atorvastatin)
- L ivalo (pitavastatin)
- I-Mevacor (i-lovastatin)
- I-Pravachol (i-pravastatin)
- I-Zocor (i-simvastatin)
Zonke izitatimende zithatha isigaba sokukhulelwa se-X, okusho ukuthi izilwane kanye / noma izifundo zabantu zibonise ingozi yokuthuthukisa ukukhubazeka kokuzalwa lapho uthatha isidakamizwa. Ngakho-ke, imishanguzo yalesi sigaba akufanele ithathwe uma ukhulelwe noma uhlela ukukhulelwa ngaphandle kokuthi izinzuzo zokuthatha imithi zihlukumeze umonakalo ongakwenzela umntwana. Akuzange kube khona ucwaningo oluningi oluhlolisisa imiphumela yezimiso eziphathekayo kwabesifazane abakhulelwe, kodwa izifundo ezikhona zikhombisa ukuthi kukhona okuncane ukuthi ukuthatha izitembu ngesikhathi sokukhulelwa kungathinta ukuthuthukiswa kwengane yakho.
Ukukhulelwa kanye nezitembu: Ucwaningo
Izifundo zezilwane azizange zifinyeleleke. Amagundane namagundane anikezwe amanye ama-statins abonise ukungahleleki okuthuthukayo, njenge-vertebrae ehlanganisiwe, izimbambo ezifakiwe, namasayizi amancane we-pup. Kodwa-ke, akuzona zonke izilwane ezibhekene nalezi ziphutha. Ucwaningo lwabantu aluzange lube nesifinyelelo.
Nakuba ukukhubazeka kokuzalwa, okufana nokukhubazeka kwenhliziyo, i-cleft palate, amaphutha we-neural tube, kanye nezinye izinto ezingahle zenzeke, zazingabhekwa njengingavamile. Ukwengeza, iningi lalaba besifazane kulezi zifundo lalineminye imibandela ekhona ngaphambili (njengokushukela kwesifo sikashukela noma ukukhuluphala ngokweqile) noma ukuthatha izidakamizwa ezingaphezu kweyodwa noma ngaphezulu kwezidakamizwa, okungenzeka futhi kwaba nendima ekuthelekeni okuphawuliwe kulezi zinkinga izifundo. Ngokomunye umkhiqizi we-statin, isenzakalo sokuthuthukisa lezi ziphutha sasingaba ngu-4%.
Ngakho-ke, uma uthatha isitatimende futhi uhlela ukukhulelwa, kufanele uvumele umhlinzeki wakho wezempilo ukuthi azi izinhlelo zakho. Umhlinzeki wakho wezezempilo angakushintshela kwenye indlela yokwelapha kusukela ubuhlobo obuphakathi kokuthatha izitembu kanye nokuthuthukiswa kwezinkinga zokuzalwa kumntanakho ngeke kukhishwe. Ukwengeza, uma usanda kuthola ukuthi ukhulelwe, kufanele wazise umhlinzeki wakho wezempilo ngokushesha ngangokunokwenzeka. Uzonquma ukuthi izinzuzo zokuthatha i-statin zingaphezu kwezingozi ezinganeni yakho.
Imithombo:
I-Bateman BT, uHernandez-Diaz S, uFischer MA, et al. Izitatimende nezinkinga zokuzalwa ezingenayo: isifundo seqembu. I-Br Med 2015; 350: h1035.
U-Godfrey LM, u-Erramouspe J, u-Cleveland KW. Ingozi ye-teratogenic yesimiso ngesikhathi sokukhulelwa.
Ann Annotherm 2012, 46: 1419-24
Ofori B, Rey E, Berard A. Risk of anomalies ezingenalutho kubasebenzisi abakhulelwe izidakamizwa statin. I-Br J Clin Pharmacol 2007; 64: 496-509.
Petersen EE, Mitchell AA, Carey JC et al. Ukuvezwa komama kubantfwana kanye nengozi yokukhubazeka kokuzalwa: uchungechunge lwamacala ochungechunge. Am J Med Genet 2008; 146A: 2701-2705.