I-Livalo (i-pitavastatin) imithi yokwehliswa kwe-cholesterol engokwesigaba se- statin yezidakamizwa. Isetshenziselwa ukuphakama amazinga e-lipid ku-hyperlipidemia eyinhloko noma i-dyslipidemia exubekile ezimweni lapho ukudla, izinguquko zendlela yokuphila, noma ezinye izidakamizwa azitholi ngokuphelele amazinga e-lipid. I-Livalo ingenye yesimiso esinamandla kakhulu emakethe.
Ngokwezibalo, abakhiqizi be-Livalo, i-2 mg ye-Livalo isebenza kahle ekunciphiseni i- lipids njengo-10 mg we- Lipitor (atorvastatin).
Ukwengeza, i-2 mg ye-Livalo inciphisa i-cholesterol ngezinga elifanayo ne-20 mg ye- Zocor (i-simvastatin). Njengamanye ama-statins, i-Livalo ithinta zonke izici zephrofayli yakho ye-cholesterol: Ihlisa i- LDL ne-triglycerides iphinde ivuse i- HDL . Ucwaningo olubalulekile oluhlola umphumela we-Livalo kumazinga e-lipid lubonise ukuthi:
- I-cholesterol ye-LDL incishiswa yi-44%
- Amazinga ephelele we-cholesterol ancipha ngamaphesenti angama-32.
- I-Triglycerides iyancipha ngo-19%.
- Amazinga we-HDL we-cholesterol akhuliswa ngokwesilinganiso sama-5%.
- I-Apolipoprotein B inciphisa cishe ngo-35%.
I-Livalo yamukelwa ukuba isebenziswe e-United States yi-Food and Drug Administration (FDA) ngo-Agasti ka-2009. Ngaphambi kokuvunyelwa e-US, i-pitavastatin yayitholakale ukusetshenziswa kwamanye amazwe ngaphezu kweminyaka emihlanu ngaphambili.
I-Livalo Isebenza Kanjani?
I-Livalo ivimbela i-enzyme ebizwa ngokuthi i-3-hydroxy-3methylglutaryl coenzyme A (HMG CoA) yokunciphisa, okuyinto iphrotheni ebalulekile edingekayo ekukhiqizeni i-cholesterol emzimbeni.
Lesi senzo sinciphisa i-cholesterol esiphelele, i-LDL, ne-VLDL cholesterol emzimbeni.
I-Livalo Kufanele Yithathwe Kanjani?
I-livalo iyatholakala kwifomu yethebulethi futhi ingathathwa noma ngaphandle kokudla kanye ngosuku, njengoba iqondiswa umhlinzeki wakho wezempilo. Amanani we-Livalo akumele adlule ngaphezulu kwe-4 mg ngosuku. I-Livalo kufanele ithathwe ngokuhambisana nokudla ukuze unciphise i-cholesterol yakho ne-triglycerides.
I-livalo ivame ukushiwo lapho impilo yakho ishintsha noma iminye imithi ayiphuli kahle i-lipids yakho.
Kumele uqiniseke ukuthi uhambela izinkampani zakho zokuqashwa kwezempilo njalo ngoba uzodinga ukuqapha amazinga akho e-lipid, kanye neminye imingcele, ngenkathi uthatha le mithi.
Ubani Ongayithathi I-Livalo?
Uma unezinye zezimo zezokwelapha ezibalwe ngezansi, akufanele uthathe i-Livalo. Kulezi zimo, umhlinzeki wakho wezempilo angakubeka ekwelapheni okuhlukile ukwehlisa lipids yakho:
- Ukungezwani komzimba ku-Livalo . Uma ngabe uke wahlukana no-Livalo noma yiziphi izithako zalo, akufanele uthathe le mithi.
- Isifo sesibindi esisebenzayo . Uma unezifo zesibindi esebenzayo noma amazinga e-enzyme yesibindi engavamile, i-Livalo akufanele ithathwe.
- Ukukhulelwa. I-Livalo ihlukaniswe njengeSigaba sokukhulelwa X. Livalo iboniswe ukuthi iwele umgoqo ophansi emagatsheni kanti kuye kwaba nemibiko yokukhubazeka nokukhubazeka okungasetshenzisweni kwezifundo zesilwane. Ngaphezu kwalokho, lokhu kuye kwabikwa nakwabesifazane abakhulelwe bethatha imithi yesimiso. Uma uhlela ukukhulelwa noma usuvele ukhulelwe futhi uthatha u-Livalo, umhlinzeki wakho wezempilo uzothola izinzuzo zokuthatha imithi empilweni yakho kanye nezingozi ezinganeni yakho.
- Ubuhlengikazi. I-Livalo iboniswe ukuthi iwele esibelethweni. Ayaziwa ukuthi yiluphi uhlobo lomphumela lokhu okungaba nalo kumntanakho.
- Ukusikisela kwe-Cyclosporine. Le mithi ingakwandisa amazinga ka-Livalo emzimbeni, okungaba nemiphumela emibi emzimbeni. Umkhiqizi uncoma ukuthi uma uthatha uLibalo, akufanele uthathe i-cyclosporine.
Yiziphi Izimo Okudingeka Zibukwe Ngenkathi Kuthatha Livalo?
Uma uthatha u-Livalo, umhlinzeki wakho wezempilo uzodinga ukukuqapha eduze uma unezimo ezithile zezokwelapha ezingase zithuthukiswe ngokuthatha imithi. Uma unemibandela elandelayo ngezansi, umhlinzeki wakho wezezempilo anganquma ukukuqala ku-Livalo kumthamo ophansi, futhi kuzodingeka akuqaphele ukuthi unqume yini ukuthi ukuthatha uLialo kungakulimaza yini.
Lezi zimo zezokwelapha zihlanganisa:
- Ama-enzyme we-fox ephakeme. Ekufundeni, uLapialo wandisa inzyme ye-aspartate aminotransferase (AST) ne-alanine aminotransferase (ALT). Nakuba ezimweni eziningi lokhu kwanda kungokwengqayizivele, umhlinzeki wakho wezempilo uyoqapha la mazinga ukuze aqiniseke ukuthi ama-enzyme akho webindi aphakanyisiwe kumazinga ayingozi.
- Isifo sezinso. Uma unesifo sezinso esilinganiselwe noma esinzima, umhlinzeki wakho wezempilo angakuqala emkhakheni we-Livalo ophansi kakhulu futhi aqaphele impilo yakho ngenkathi emithi.
- Amazinga wegazi we-glucose ephakeme. Ucwaningo lubonise ukuthi i-Livalo ingandisa ukwanda kwe-hemoglobin A1C nokuzila ukudla kwe-glucose. Uma unesifo sikashukela, umhlinzeki wakho wezokunakekelwa kwezempilo angabheka lezi zakhi egazini lakho futhi alungise umthamo wakho we-Livalo.
Yiziphi izinhlobo zemiphumela emibi eyokwenza incwadi ye-Livalo?
Imiphumela emibi kakhulu ehlanganisa ubuhlungu emuva, izinkinga zomzimba (njengokuqunjelwa noma isifo sohudo), ubuhlungu be-muscle, nobuhlungu emaphethelweni. Eminye imiphumela emibi engavame ukuhlangenwe nakho ihlanganisa ubuhlungu bekhanda kanye nobuhlungu obuhlangene. Uma uhlangabezana nanoma yimiphi imiphumela emibi ekuthathe i-Livalo ehlala isikhathi eside noma ephazamisayo, kufanele uvumele umhlinzeki wakho wezempilo ukuthi azi.
Njengamanye ama-statins, umphumela wecala ongajwayelekile - i-rhabdomyolysis - ingenzeka nakwabantu abathatha i-Livalo. Izimpawu ze-rhabdomyolysis zifaka imisipha ebuhlungu kanye nobuthakathaka, kanye nomchamo ombala we-soda. Ingozi yakho yokubhekana nale miphumela emibi ingenzeka uma uthatha ezinye izidakamizwa, iminyaka ekhulayo, nezinye izimo zezokwelapha. Uma uthola noma yiziphi izimpawu ze-rhabdomyolysis, kufanele usheshe wazise umhlinzeki wakho wezempilo.
Zikhona yini Imithi Engahle Ikwazi Ukusebenzisana Ne-Livalo?
Izidakamizwa ezilandelayo zingase zihlanganyele ne-Livalo, zandisa amathuba okuba nemiphumela emibi (ikakhulukazi i-myopathy). Ngaphandle kwezidakamizwa ezinciphisa i-cholesterol ezibalwe ngezansi, lezi zidakamizwa zingandisa ama-Livalo emzimbeni wakho.
- Izidakamizwa ezinciphisa i-cholesterol (i- nicotinic acid , i-fibrates)
- Rifampin
- I-Erythromycin
- I-Colchicine
Lokhu akulona uhlu oluphelele. Kumele uvumele umhlinzeki wakho wezempilo ukuba azi yonke imithi - kuhlanganise imithi yemithi kanye nezidakamizwa ezingaphezu kwe-counter - ukuthi uthatha ngenkathi uthatha i-Livalo. Lokhu kuzokusiza umhlinzeki wezokunakekelwa kwezempilo ukuthi akuqaphele ukuthi kungenzeka ukusebenzisana kwezidakamizwa ngenkathi ethatha imithi. Uma kudingeka ukuba uthathe esinye sezidakamizwa ezibalwe ngenhla, umhlinzeki wakho wezempilo uzodinga ukulungisa umthamo wakho, ukuqapha eduze nemiphumela emibi, noma ukuyeka esinye sezidakamizwa.
Okubalulekile
I-Livalo yilapho imishanguzo yamuva ye-lipid-ukwehlisa eyamukelwa e-United States. Kwezinye izifundo, kubonakala sengathi kuphumelela ekunciphiseni i-lipids ngokulinganisa okulinganayo kwe-simvastatin ne-atorvastatin. I-Livalo ibonakala ihamba ngomunye umgwaqo esibindi ukuze ihlolwe ngokuqhathaniswa namanye ama-statins, okunciphisa inani lokusebenzisana kwezidakamizwa elibhekwe kubantu abathatha le mithi. Noma kunjalo, i-Livalo ayizange ifunde kabanzi ekuvimbeleni ukufa noma ukukhubazeka ngenxa yesifo senhliziyo.
Imithombo
Duggan ST. I-Pitavastatin: ukubuyekezwa kokusetshenziswa kwayo ekulawulweni kwe-hypercholesterolemia noma i-dyslipidemia exubekile. Izidakamizwa 2012; 72: 565-584.
Ose L, uBudinski D, uHounslow N, et al. Ukuqhathaniswa kwe-pitavastatin ne-simvastatin e-hypercholesterolaemia eyinhloko noma i-dyslipidaemia ehlangene. I-Curr Med Res ne-Opin ka-2009; 25: 2755-64 15.
U-Budinski D, u-Arneson V, uHounslow N, et al. I-Pitavastatin uma kuqhathaniswa ne-atorvastatin e-hypercholesterolemia eyinhloko noma i-dyslipidemia ehlangene. I-Clin Lipidol 2009; 4: 291-302
I-LIVALO [iphakheji efakiwe]. Cincinnati, OH: Kowa Pharmaceuticals America, 10/2013
I-Micromedex 2.0. I-Truven Health Analytics, Inc. I-Greenwood Village, CO. Itholakala ku-: http://www.micromedexsolutions.com. Ifinyelele ngo-Februwari 10, 2016