Ingabe kungenzeka ukuthi ixhunywe ne-lymphoma?
UPaul Langerhans wazalelwa eBerlin, eJalimane, ngoJulayi 25,1847, indodana yodokotela waseJalimane. Ukuphuma ukutadisha imithi efana noyise, osemusha wenza ukutholakala okubalulekile kuyilapho eseyi-undergraduate. Ukutholakala kwakhe yilokhu okuye kwaziwa ngokuthi ama-epidermal Langerhans amangqamuzana, angumdlali oyinhloko esimweni esaziwa ngokuthi i-Langerhans cell hertiocytosis.
Ukuthola amaseli we-Langerhans Dendritic
ULangerhans wahlanganyela emncintiswaneni ovulekile owahlelwa iBerlin University. Usosayensi ogama lakhe linguJulius Cohnheim usuvele wayesebenzisa indlela yokubona izinzwa zokusebenzisa izinsimbi ezikhethekile zegolide kanye ne-microscopy elula.
Esebenzisa amasu e-chloride e-Cohnheim egolide ngo-1868, i-Langerhans ibonwe ngezithombe futhi yachaza okuthile esikhumbeni esingafani nezinye izakhi zesikhumba-wachaza ngokuthi i-dendritic ngoba yayinezihlahla ezifana nesihlahla; kodwa futhi wathi kwakungewona u-pigmentary. Ngamanye amazwi, ayengenayo i-melanin ye-pigment ekhona kwamanye amangqamuzana okuthiwa i-melanocytes, aphinde ahlanganiswe, futhi yiwo amangqamuzana avela kuyo i- melanoma .
Ngaleso sikhathi, wachaza leli cell cell elingenayo pigmented kwaba uhlobo oluthile lwe-receptor lokubonisa esikhumbeni kwisistimu yezinzwa. Ngaphezu kwekhulu leminyaka kamuva, ososayensi bazofunda ukuthi amangqamuzana eLangerhans esikhumba anemisebenzi ebalulekile esimisweni somzimba sokuzivikela .
Ngo-1973, uDkt. Inga Silberberg wathola ukuthi amangqamuzana e-Liderhans e-epidermal abonisa "indawo engaphandle ye-immune system." Namuhla, amangqamuzana e-Langerhans abhekwa njenge-subset yomndeni wamaseli e-dendritic, futhi yi-subset efundwa kakhulu kakhulu.
Amaseli e-Langerhans atholakala esikhumbeni acatshangwa ukuthi asebenze njengamaseli e-antigen avelayo.
Ama-antigens ayinhloko 'yamathegi' yeselula ukuthi amasosha omzimba angakwazi ukuwabona. Amaseli e-Antigen avela (APCs) amangqamuzana asebenza ngokukhethekile ekuthatheni ama-antigens, ukuwacubungula, nokuwabonisa ngendlela ekhethekile ukuze amanye amangqamuzana omzimba angakwaziswa ukuba khona kwe-antigen yangaphandle. Ngesizo sama-APC, amangqamuzana egazi amhlophe e-lymphocyte akwazi ukubona futhi aphendule ama-microbes athize kanye nabanye abahlaseli.
Izici zeLangerhans Cell Histiocytosis (LCH)
I-Langerhans cell hertiocytosis, noma i-LCH, ikhethwa esikhathini esikudala, "i-histiocytosis X," kodwa kokubili amagama avela ezincwadini zezokwelapha. I-LCH empeleni yiqembu lezifo ezinokukhula okungalawulwa okungalawulwa kwamaseli e-Langerhans. Kungenzeka nanoma yisiphi isikhathi, nakuba kungavamile kubonakala kubantu abadala. Nakuba i-LCH yaziwa cishe ngekhulu leminyaka, ososayensi abakaliqondi yonke imininingwane mayelana nokuthi kubangelwa yini.
I-LCH ivame ukuhlotshaniswa neyodwa noma eminingi "ekhishwe ngaphandle" ebonakala ezindaweni ezilahlekile ithambo emibonweni ye-imaging-izindawo lapho, lapho i-biopsied, ibonisa ukuthi amathambo asetshenzisiwe yi-histiocytes ene-nuclei enobhontshisi.
I-Histiocytes, njenge-macrophage noma amaseli e-dendritic, amangqamuzana omzimba omzimba abhubhisa izinto zangaphandle emzamweni wokuvikela umzimba ekutheleleni.
La ma-histiocytes, kanye nama-lymphocytes, ama-macrophages, nama-eosinophil, angase ahlasele cishe zonke izidumbu kodwa ikakhulukazi isikhumba, ama-lymph nodes, amaphaphu, i-thymus, isibindi, i-spleen, i-bone marrow, noma isimiso sezinzwa esiyinhloko.
Yini LCH Ephathelene Nokwenza Lymphoma?
Abanye ochwepheshe bathi i-LCH ingaba ukukhula okusebenzayo kwamangqamuzana e-Langerhans elandela i-chemotherapy noma i-radiotherapy ye-Hodgkin's disease. Lokhu kungenye yezinkolelo eziningana.
Amacala amaningana e-Langerhans 'cell histiocytosis ehlobene ne-malignant lymphoma kuye kwabikwa esikhathini esidlule. Amacala abikiwe, noma kunjalo, okwenzekile nge - lymphoma ebulalayo, kanye nokulandela i -lymphoma.
I-LCH ivame kakhulu ezinganeni kusukela eminyakeni eyodwa kuya kwemibili ubudala, okungase kuzwakale ivalo, kepha khumbula ukuthi i-LCH ayidlangalaleni.
Izimpawu zixhomeke kumasayithi okubandakanyeka futhi lesi sifo sinqunyelwe ohlelweni olulodwa lomzimba-nje nje amathambo, ngokwesibonelo, cishe kwesigamu samacala. Ngezinye izikhathi ukuhlasela kwethambo akukhiqizi izimpawu, kodwa ngezinye izikhathi kungase kube nobuhlungu ezindaweni ezitholakala endaweni. Ukubandakanyeka kwesibonakala kubonakala ngamaphesenti angama-40 amacala, futhi uphawu oluvame ukwedlula isikhumba ngukushisa okunjenge-eczema kufana nesifo sovubelo.
I-LCH ingaba nzima ukuyihlolisisa, kodwa khumbula ukuthi ukuvakashelwa njalo kudokotela wakho kanye nenkhulumomphendvulwano evulekile kwandisa kakhulu amathuba okuthola uma kukhona okungajwayelekile.
> Imithombo:
> Diapedia. I-Living Bookbook of Diabetes. Paul Langerhans.
> Jaitley S, Saraswathi T. Pathophysiology of Langerhans Amaseli. I-Journal ye-Oral and Maxillofacial Pathology: JOMFP . 2012; 16 (2): 239-244.
> Langerhans P. Uber Die Nerven Der Menschlichenhaut. Archives of Anatomy Pathological 1868; 44: 325-37.
> Li X, Deng Q, Li YM. I-Case of the Langerhans 'Cell Histiocytosis Elandela Izifo ZaseHodgkin. I-Molecular and Clinical Oncology. 2016; 5 (1): 27-30.
> Satter EK, High WA. I-Langerhans Cell Histiocytosis: Ukubuyekezwa Kwezindinganiso Zanje Zomphakathi We-Histiocyte. I-Pediatr Dermatol . 2008 Meyi-Jun. 25 (3): 291-5.