Amasosha omzimba omzimba afakwe ku-MS
Izakhi zakho zofuzo ziyisici esibalulekile uma ngabe usengozini yokuthuthukisa i-MS , njengoba usekelwa yizo zombili izifundo zomndeni nezesayense.
Izifundo zomndeni njengobufakazi bokuthi iGenesis idlala indima e-MS
Kubantu abaningi, kune-1 ku-750 ithuba (amaphesenti angu-0.1) ithuba lokuthi umuntu azokuthuthukisa i-MS. Kodwa iwele elifanayo lomuntu one-MS linamathuba angama-25 kuya kwangu-40 amathuba okuthuthukisa i-MS, kanti ingane noma ingane yomuntu onama-MS unethuba elingamaphesenti angu-3 ukuya kwangu-5.
Ucwaningo lwezesayensi njengobufakazi bokuthi iGenesis idlala indima e-MS
Ucwaningo lwango-2007 lwanyatheliswa eNew England Journal of Medicine lwathola isifo esisha se-genetic risk for multiple sclerosis (MS). Ucwaningo lubonisa ukuthi abantu abanezinhlobo ezithile zezakhi zofuzo ezihlukene ezihilelekile ohlelweni lokuvikela omzimba (i-IL7RA ne-IL2RA) kungenzeka ukuthi babe ne-MS kunabantu abangenazo lezi zinguquko.
I-IZ7RA ne-IL2RA yiziprotheyini eziqondisa izenzo zenye uhlobo lwe-cell cell (T cells). Njengoba izakhi zofuzo zilawula ukuthi amaprotheni akwenziwa kanjani emzimbeni, izinguquko zohlobo lweprotheyini zimelela umehluko ezakhiweni zofuzo.
Inguqulo ehlobene ne-MS yeprotheyini ingase ibe nomthelela ku-MS ngokuqondisa lawo maseli omzimba ukuhlasela isistimu yezinzwa, okuholela ekwenzeni ukuxoshwa kanye nezilonda ebuchosheni nasendlini yomgogodla. Lo monakalo, futhi, ubangela izimpawu eziningi ezihlukahlukene ze- MS . Ngokuthakazelisayo, ukuguqulwa kwe-IL2R kuye kwahlotshaniswa nohlobo lwesifo sikashukela se-type 1 kanye nesifo se-Graves, kanye nokukhathazeka okuzenzakalelayo .
Ucwaningo oluthile luye lwasekela ukuxhumana phakathi kwe-MS namagciwane alawula amasosha omzimba omuntu. Ingxenye ekhohlisayo yilapho kungenzeka ukuthi iningi lezinguquko zofuzo, okulinganisiwe ukuthi yi-50 kuya ku-100 yi-National MS Society, enquma ingozi yomuntu yokuthuthukisa i-MS futhi uma ikhula i-MS, yeka ukuthi inzima kanjani.
Ukuhlaziya idatha ye-MS yofuzo kuyinkimbinkimbi futhi kuyadla isikhathi, kepha kuyabaluleka, ikakhulukazi uma kungcono ukuhlela imithi ye-MS.
Ngaphansi
Kubalulekile ukuqonda ukuthi nakuba izakhi zofuzo zidlala indima ebalulekile ekuthuthukiseni i-MS futhi kungenzeka ukuthi inkambo ilandela, akuzona zonke izinto. Ngamanye amazwi, i- MS akuyona ukugula okuzuze ngokuqondile, ngakho-ke akukho siqinisekiso sokuthi uzokwenza noma ngeke uyithole ngokusekelwe emlandweni womndeni wakho (noma ikhodi yakho yezofuzo).
Esikhundleni salokho, indlela i-MS eqala ngayo futhi ebonakala ngayo kumuntu cishe iyinkimbinkimbi, ehilela ukushintsha phakathi kwezakhi zofuzo zomuntu nemvelo yakhe. Isibonelo, uchungechunge lwezinguquko zofuzo lungenza umuntu abe yingozi kakhulu ekuthuthukiseni i-MS uma evezwa endaweni ethile yemvelo, njengegciwane (nakuba, asazi lezo zimbangela ezicacile okwamanje).
Njengamanje, odokotela abazenzi ukuhlolwa kofuzo kubantu abane-MS noma amalungu omndeni alabo abane-MS. Kodwa njengoba ukuthuthukiswa kwezesayensi ze-gene (okusheshayo kakhulu), ukwelashwa kungase kuguquke ngokusekelwe komuntu ngamunye.
Imithombo:
Gourraud, PA, Harbo, HF, Hauser, SL, & Baranzini, SE (2012). I-genetics ye-multiple sclerosis: ukubuyekezwa okubuyekeziwe. Ukubuyekezwa okungavumelekile , uJulayi; 248 (1): 87-103.
I-International Multiple Sclerosis Genetics Consortium, et al. (2007). Izingozi zengozi ye-multiple sclerosis ekhonjiswe isifundo se-genomewide. I-New England Journal of Medicine, Aug 30; 357 (9): 851-62.
I-National MS Society. Ubani othola i-MS? (Epidemiology).
I-National MS Society. Izinto Eziyisisekelo: I-Genetics.
USadovnick, AD, et al. (1993). Isifundo esisekelwe kubantu esiphezulu se-multiple sclerosis emawele: buyekeza. Ama-Annal of Neurology, Mar; 33 (3): 281-5.