Ukuba namazinga aphakeme e-LDL ama-cholesterol angakubeka engozini yokuthuthukisa isifo senhliziyo. Iziqondiso zincoma ukuthi amazinga akho e-LDL kufanele abe ngaphansi kuka-100 mg / dL. Nokho, hhayi kuphela ukuthi amazinga aphezulu e-LDL ama-cholesterol akubeka engozini yesifo senhliziyo, uhlobo lwezinhlayiya ze-LDL ezijikelezayo egazini lakho lungenza umehluko. Izinhlayiya ze-LDL zingaba phakathi kwekhulu nokukhululeka kuya ezincane.
Izinhlayiyana ezincane ze-LDL cishe ziba ne-oxidized, okwenza zibe nengozi kakhulu empilweni yakho yempilo. I-LDL ene-oxidised ingaveza ukuvuvukala emithanjeni eyenza igazi ezithombeni zakho nakwezinye izicubu, ngaleyo ndlela kukhuthaza ukuqina kwe-atherosclerosis futhi kwandisa ingozi yokuba nesifo senhliziyo noma isifo sohlangothi.
Ifomu le-LDL elixhasiwe?
I-oxidation ye-LDL kucatshangwa ukuthi iyenzeka uma izinhlayiya ze-LDL ze-cholesterol emzimbeni wakho zisabela ngama-radicals mahhala. I-LDL enezinyosi ngokwayo isuke isasebenza kakhulu ngezicubu ezizungezile, ezingabangela ukulimala kwezicubu. Ezinye zezinto ezibonakala zikhuphuka amazinga we-LDL oxulisiwe zihlanganisa:
- Ukudla ukudla okuphezulu kumafutha okudlulisa
- Ukubhema
- Ukuba nesifo sikashukela esingalawulwa kahle
- Kutholakala ukuthi unesifo se-metabolic syndrome
Uma i-LDL ishicilelwa, ihamba ngokuqondile ngaphakathi kwe-lining (endothelium) yimuphi umshini emzimbeni, kufaka phakathi umthambo we - carotid , umthambo we-coronary noma imishanguzo enika imilenze yakho nezingalo ngegazi.
Lapho lapho, ikhuthaza ukuqoqwa kwamangqamuzana avuthayo, njenge-macrophages, nama-platelets esakhiweni somkhumbi futhi akhuthaze ukunamathela kwawo endaweni ewonakele. Ama-macrophage amaningi, i-cholesterol nezinye i-lipids ziqala ukuqoqa esakhiweni, ukwakha i-plaque eqala ukukhula ngokweqile.
Ngokuhamba kwesikhathi, lokhu kunganciphisa - noma kuvimbele ngokuphelele - inani lokugeleza kwegazi eliya endaweni eyodwa noma ngaphezulu zomzimba. Lokhu kungaholela ezimweni ezihlukahlukene zempilo, kuhlanganise nesifo senhliziyo, isifo se-circular or vascular dementia.
Yini Ongayenza Ukuvimbela Ukwakhiwa kwe-LDL Oxidized?
Kunezinto eziningi ongayenza ukuvimbela ukwakheka kwe-LDL ene-oxidized, futhi eziningi zazo zihilela ukwenza izinguquko ezimbalwa kumikhuba yakho yansuku zonke ukwehlisa i-cholestolol yakho ye-LDL , njenge:
- Yeka ukubhema.
- Hlanganisa amafutha esitokisini ekudleni kwakho. Ukudla okungaqukatha amafutha okudlulisa kubandakanya ama-pastries, ukudla okujulile okuthosiwe, ama-mbatata ama-chips kanye nokunye okuphekwe ngesinqumelo.
- Engeza izithelo nemifino ekudleni kwakho. Akugcini nje ukuthi ziqukethe izakhi eziningi futhi ziba namafutha aphansi, nazo zinezidakamizwa eziphikisana nezidakamizwa ezingasiza ekunciphiseni uketshezi lwe-LDL.
- Uma uthola ukuthi unesifo sikashukela noma isifo se- metabolic , thola lezi zimo ngaphansi kokulawula. Lokhu kuzofaka ukulahlekelwa isisindo, ukudla ukudla okunempilo nokuzivocavoca. Uma izinguquko zokuphila azikusizi ukuthi ulawule amazinga okushukela egazini nesisindo sakho, umhlinzeki wakho wezempilo angakhuluma nawe ngokuthatha imithi yokulawula le mibandela.
Kwezinye izimo, ungadinga imithi yokusiza ukwehlisa i-cholesterol yakho. Eminye yale mithi yokwehliswa kwe-cholesterol, efana nezitembu, ibuye ibe nezakhiwo eziphikisayo ezinganciphisa i-cholesterol yakho futhi ivimbele ukuvuvukala okusiza ekusunguleni ukwakheka kwe-atherosclerosis.
> Imithombo:
I-Third Report of the National Cholesterol Education Program (NCEP) Iphaneli Yomhloli Yokuthola, Ukuhlola Nokuphathwa Kwegazi Eliphezulu le-Cholesterol ku-Adult (PDF), July 2004, I-Institutes National Health: I-National Heart, Lung, ne-Blood Institute.
I-Dipiro JT, Pharmacotherapy: Indlela Yokuphilisa I-Pathophysiological., Edition 9. McGraw-Hill Education 2014.
UTrpkovic A, Resanovic, uStanimirovic J et al. I-Oxidized Low-Density Lipoprotein njenge-Biomarker yezifo zenhliziyo. Crit Rev Rev Clin Lab Sci 2015; 52: 70-85