I-Viscosupplement ibuyisa izimpahla ze-Fluid Joint evamile
I-Synvisc (i-hylan GF 20) i-elastic, i-viscous, high molecular weight fluid equkethe i-hylan I-fluid, i-hyel B gel, namanzi anosawoti. I-Hylan A ne-hylan B zitholakala ku-hyaluronan (ebizwa nangokuthi i-sodium hyaluronate) eyenziwa yinkomo yenkukhu. I-Hyaluronan nayo yinto engokwemvelo etholakala emzimbeni, ngokuqondile, ngokukhululeka kwamalungu.
I-hyaluronan yemvelo yomzimba yenza njenge-lubricant and shock absorber okuyinto edingekile emsebenzini ohlangene ojwayelekile.
I-Synvisc ingenye ye-hyaluronates esetshenziselwa ukwelashwa okubizwa ngokuthi i- viscosupplementation . Ngezinye izikhathi ukwelashwa okubizwa ngokuthi ukwelashwa okunegazi okuhlangene, ama -ject injini ye-hyaluronan, noma ama-injection ye-hyaluronate.
Izinkomba ze-Synvisc
Amagciwane e-Synvisc avunyelwe ukwelashwa ubuhlungu ezigulini ezine- osteoarthritis yamadolo ahlulekile ukuphendula ukwelapha okunamandla okunye, njengama- analgesics okungewona ama-narcotic noma izinketho zokwelapha ezingekho izidakamizwa. E-osteoarthritis, kungase kube khona inani elincane le-hyaluronan noma ikhwalithi ye-hyaluronan ingancipha. Ukusetshenziselwa i-Synvisc kwamanye amalunga kuyaphenywa, kodwa akukavunyelwe.
I-synvisc ijojowe, isebenzisa isiraphu equkethe 2 ml, ngqo emadolweni ekuhlanganyeleni ukubuyisela izakhiwo zokugcoba nokugcoba okujwayelekile kwamanzi ahlangene.
Kukhona omunye umkhiqizo we-Synvisc, owaziwa nge-Synvisc-One, ophathwa njengomjovo owodwa (ngesikhathi esisodwa) umjovo we-intra-articular (6 ml).
Ama-Synvisc Injections - Ingemuva
- Ukuhlolwa kwe-Viscosupplementation kuye kwacutshungulwa ukwelashwa kwe-osteoarthritis kusukela ngawo-1970.
- I-Synvisc yayivunyelwe yi-FDA ngo-08/08/97.
- Ama-synvisc injection ngokuvamile anikezwa njengochungechunge lwezilwane ezintathu, kanye ngesonto, ngesonto elilodwa elilodwa elihlukile. I-Synvisc-One ithuthukiswe njengengxube yesikhathi esisodwa, njengenye indlela eya ochungechungeni lwezintathu nge-Synvisc.
- Ukuze uthole imiphumela emihle, i-osteoarthritic synovial fluid ngokuvamile isuswe emadolweni ngaphambi kokujova kokuqala.
- I-Synvisc ibhekwa njengokwelashwa noma ukwelapha, hhayi umuthi.
Imiphumela emibi kanye nezingozi
Imiphumela emibi kakhulu ehambisana ne-Synvisc injection ifaka ubuhlungu emgqeni ojosiwe, ukuvuvukala emgqeni ojosiwe, nokuxuba okuhlangene . Ezinye izenzakalo ezimbi ezingahle zenzeke ezingase zivele nge-intra-articular injection zibandakanya i-arthralgia (ubuhlungu obuhlangene), ukuqina okuhlangene , ukuxhuma okuhlangene, ukuvuvukala okuhlangene , ukufudumala okuhlangene , ubuhlungu endaweni yokujola, isifo samathambo, isifo samathambo, nokungajwayelekile.
Ukuhlolwa kokuthunyelwa kwe-post-marketing ye-3-injection regimen ye-Synvisc yembule ezinye izimo ezingavamile ezivamile ezingabonakali ezihlanganisa ukuqhuma, ukusikeka komkhuhlane, umkhuhlane, isisindo sokuphuza ikhanda, ikhanda, isizungu, izikhumba, izinkinga zomzimba, i- malaise , izinkinga zokuphefumula, i-edema ye-peripheral, futhi okungajwayelekile, i-thrombocytopenia (amapleletthi aphansi ).
Ukungahambisani nokuxwayiswa
I-synvisc akufanele ijojelwe kubaguli abane-hypersensitivity eyaziwayo kwimikhiqizo ye-hyaluronan. Futhi, i-Synvisc akufanele ijowe ngamadolo ngokutheleleka okuhlangene, izifo zesikhumba noma izifo, noma ukutheleleka endaweni okuzungezile isayithi lokujola.
I-Synvisc kufanele isetshenziswe kuphela njengemjovo ye-intra-articular (ngaphakathi kokujoyina).
Uma injected ngaphandle kokujoyina izicubu ze-synovial noma i-capsule ehlangene, izenzakalo ezimbi zendawo noma zesistimu zingenzeka. Umjovo we-Intravascular of Synvisc (ungena emthonjeni wegazi) ungabangela izenzakalo ezimbi ezihlelekile futhi kufanele zigwenywe.
Ngemuva kwesilwane se-Synvisc, kunconywa ukuthi iziguli kufanele zigweme imisebenzi eqinile noma imisebenzi ende yokwehlisa isisindo amahora angu-48. Xoxa ngezincomo ezithile eziphathelene necala lakho ngabanye nodokotela wakho.
Ukuphepha nokusebenza kwe-Synvisc kwabesifazane abakhulelwe noma abesifazane abahlengikazi abazange basungulwe.
Uma unesifo somzimba ukuze uthole amaphiko, amaqanda, izinkukhu, noma ezinye imikhiqizo ezivela ezinyoni - yazise udokotela wakho.
Ukufanisa i-Synvisc ne-Corticosteroid Injections
I-Synvisc ibonakala ngokuphumelelayo ekujoeni kwe- corticosteroid engaphakathi kwe-intra-articular enokuqala okusheshayo kodwa isikhathi esifushane sokusebenza kune-Synvisc. Ukujova okuphindaphindiweyo kwe-Synvisc kuthathwa njengokuphephile kunama-corticosteroids kuziguli ezinezinkinga ezingenza ukuthi i-corticosteroids iphikisana. Futhi, kufanele kuqashelwe ukuthi ukusetshenziswa kwe- NSAID kungase kwehle kwezinye iziguli ezilandela izijovo ze-synvisc.
Imithombo:
I-synvisc yolwazi lwesineke, i-Sanofi US.
http://products.sanofi.us/synvisc/synvisc.html
Ukwazisa ngesineke Synvisc-One. I-Sanofi US.
http://products.sanofi.us/synviscone/synviscone.html
I-Hylan GF 20: Ukubukezwa kokuphepha nokusebenza kwayo ekulawulweni kobuhlungu obuhlangene e-Osteoarthritis. UMagliore A. et al. I-Clinical Medical Insights: I-Arthritis Musculoskeletal Disorders. 2010; 3: 55-68.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998981/