Ukufakelwa kwe-Fecal microbiota (FMT) kuqhutshwa uphenyo njengokwelashwa okunempilo kwezinkinga ezihlukahlukene zezempilo, ikakhulukazi ukutheleleka kweClostridium difficile . I-FMT yindlela yokuthuthukisa impilo ye-colonic ngokusebenzisa ukwethulwa kwendaba yefecal equkethe ama- bacterial ahlukahlukene aphilile . Njengoba kunakekelwa okwengeziwe indima yokugulisa amabhaktheriya ku-IBS , kubonakala kungokwemvelo ukubuza ukuthi i-FMT ingaba ukwelashwa okuphumelelayo kwe-IBS.
Ake sibuke ukuthi yi-FMT, ukuthi isebenza kanjani, nokuthi yikuphi ukucwaninga okuveziwe mayelana nokusebenza kwayo kwe-IBS.
Kuyini FMT?
I-FMT, eyaziwa nangokuthi yi-bacteriotherapy, iyinkqubo lapho indaba yezinambuzane ezivela kumuntu onempilo idluliselwa kumuntu ogulayo. Esikhathini esiningi, lokhu kudluliswa kwenzeka ngesikhathi senqubo ye- colonoscopy , futhi kancane kancane ngokusebenzisa ukusetshenziswa kwe-enemas. Ezimweni ezinzima, le ndaba ingadluliselwa besebenzisa ithubhu yangasese eya emathunjini amancane .
I-FMT iye yajabulela ukwamukelwa okwandayo njengendlela yokwelapha ejwayelekile ngenxa enkulu yokusebenza kwayo ekwelapheni i- C , kepha futhi ngenxa yokuthi ososayensi baqhubeka begxile ekwenzeni i- gut dysbiosis iningi lezinkinga zezempilo. I-FMT ibonakala ingcono kakhulu ekusetshenzisweni kwama-antibiotic, ama-prebiotics, nama-probiotics ekwenzeni ngcono impilo yegulane, ngenxa yokuthi indaba enempilo ye-fecal iqukethe izinhlobo ezihlukahlukene kakhulu "ezinobungane" zamabhaktheriya.
Kuyini ukuphathwa kwe-FMT?
Njengoba kuphawuliwe ngenhla, i-FMT iye yaba ukwelashwa okuyinhloko kweC C. , ikakhulukazi lapho kwenzeka khona. Ucwaningo lwezesayensi luqhutshwa ukuhlola i-FMT njengendlela yokwelashwa okuphumelelayo:
- Izifo ezikhukhumeza izifo
- Izifo ezizenzakalelayo
- Isifo sikashukela
- I-metabolic syndrome
- Ukukhuluphala
Yini ehilelekile ku-FMT?
I-FMT ayikwazi ukuvela ngaphandle kwabanikeli.
Abantu bahlolwe ukuqinisekisa ukuthi banempilo. Abanikeli banikela ngamasampuli ase-stool abese abhekwa ngokulungiselela inqubo. Amasampula amasha ajwayelekile asetshenziswa, nakuba olunye ucwaningo luqhutshwa ekusebenzeni kwezinto ezibandayo.
Njengoba kuxoxwe ngenhla, i-FMT ingenziwa nge-colonoscopy, tube yangasese, noma i-enema. Ikholomu ye-colonoscopy idinga "u- prep " ofanayo njengekolonoscopy yendabuko, ukuze uhlanze ikoloni.
Imiphumela emibi ye-FMT ngokuvamile impawu ezincane zokugcina ukudla - noma azikho. Imiphumela emibi kakhulu ayidabuli futhi iyenzeka ngesilinganiso esifanayo nanoma yikuphi inqubo ye-colonoscopy, yangasese noma ye-enema.
Ngenxa yokuthi abanikeli bezitofu bavela komunye umuntu, kunezinto ezikhathazayo mayelana nezifo ezithunyelwa ngabanikeli ukuze zithole izitoreji (njengeminikelo yegazi, ngaphambi kokuhlolwa okufanelekile). Odokotela nabacwaningi basathuthukisa izinqubomgomo nezinqubo zokuhlola ukunciphisa le ngozi.
Ingabe FMT Ingasiza IBS?
Umqondo we-FMT we-IBS uyamangalisa. I-Dysbiosis, isimo esingenampilo samagciwane ezinambuzane se-intanethi kuye kwaxhunyaniswa nezinkinga ze-motility kanye ne- visceral hypersensitivity eyenza izimpawu ze-IBS. Uma i-FMT ingasiza ukulungisa i-dysbiosis, izolandela ukuthi iziguli zizobhekana nokunciphisa izimpawu.
Ukucwaninga nge-FMT ye-IBS kuyisiqalo kodwa kuyathembisa. Ukutadisha okuncane okubandakanya iziguli ezingu-13 ezingazange zamukele ukwelashwa kwendabuko ye-IBS, kubonise ukuthi le nqubo yasiza ukunciphisa izimpawu ezingaphezu kwezingxenye ezimbili kwezintathu zabahlanganyeli - ngokuthuthukiswa okubonwe ezimpawu ezihlukahlukene ezakha i-IBS. Olunye ucwaningo luye lwashicilelwa lapho iziguli ezingu-45 ezinokuqothulwa okungapheli zaphathwa nge-FMT kanye ne-fecal enema infusions. I-89% yabathintekayo yabika ukuthi kunciphisa ngokushesha ukuqothulwa, ukuhlukumeza kanye nobuhlungu besisu. Iziguli ezingu-30 zabika emuva ezinyangeni ezingu-9 kuya ku-19 ngemuva kwenqubo.
Kulaba bantu abangu-30, 60% babhekana nokunyakaza okujwayelekile okwamathumba ngaphandle kokuthi basebenzise amakhemikhali.
Okubalulekile
Ngalesi sikhathi, kusemgwaqeni kakhulu emdlalweni ukudweba noma yiziphi iziphetho mayelana ne-FMT yokukhetha ukwelashwa okusebenza kahle kwe-IBS. Kuyoba okuthakazelisayo ukubona ukuthi ngabe ucwaningo lwesikhathi esizayo lusekela yini ukutholwa kokuqala okucwaninga. Yini ebalulekile ukuthi uqinisekise uma inqubo ikwazi ukunikeza inzuzo ecacile ngaphezu kwezinye izinketho zokwelashwa ukuze kulungele isikhathi sayo futhi uqinisekise ukuthi ayithwali noma yiziphi izingozi zokuphepha zesikhathi esifushane noma zesikhathi eside.
Imithombo:
Aaronadis, O. & Brandt, L. "Intombazane Microbiota kanye ne-Efficacy ye-Fecal Microbiota Transplantation kwizifo zesisu" Gastroenterology & Hepatology 2014 10: 230-237.
I-Borody, T., Brandt, L. & Paramsothy, S. "Ukufakelwa kwe-Faecal Microbiota Ukutshalaliswa Kwemvelo: Isimo Sanje Nokuthuthukiswa Kwesikhathi Esizayo" I- Opinion yamanje ku-Gastroenterology 2014 30: 97-105.
I-Borody, T., Paramsothy, S. & Agrawal, G. "I-Fecal Microbiota Transplantation: Izinkomba, Izindlela, Ubufakazi, Neziqondiso Zesikhathi Esizayo" Imibiko Yamanje Ye-Gastroenterology 2013 15: 337.
UMalnick, S. & Melzer, E. "I-Microbiome Yabantu: Kusuka Ebhodini Lokungena Emgodini" I- World Journal of Gastrointestinal Pathophysiology 2015 6: 79-85.
Rossen, N., et.al. "Ukufakelwa kwe-Fecal Microbiota njenge-Novel Therapy ku-Gastroenterology: Ukubuyekezwa Okuhlelekile." I-World Journal of Gastroenterology 2015 21: 5359-5371.