Ama-bacteria angase adlale indima ekudleni kwengqondo yesifo sofuba (IBS). Uma uhlupheka nge-IBS, ngezinye izikhathi ungase ucabange ukuthi kukhona impi eqhubeka ngaphakathi emzimbeni wakho. Ukucwaninga kwe-IBS yakamuva kusikisela ukuthi ungase ufike kwenye into.
Isistimu yakho yamathumbu igcwele amabhiliyoni amabhaktheriya azo zonke izinhlobo ezahlukene; wonke amagciwane abizwa ngokuthi i- flora .
Esimweni sempilo enhle, wonke lawa ma-bacteria adlala kahle. Ngeshwa, kunezikhathi lapho kubhekene khona ukuphazamiseka kwesilinganiso se-flora, isimo esaziwa ngokuthi i- dysbiosis emathunjini , okubangelwa izimpawu ezingavumisi zamathumbu. Lokhu kungahle kwenzeke ngezizathu ezihlukahlukene, ezifana nokubhekana ne- gastroenteritis (isisu somkhuhlane) noma njengomphumela wemithi elwa namagciwane. Ezweni lokucwaninga , kunezici ezithile ezintsha ukuthi ukuphazanyiswa okuqhubekayo emagodini okugaya kungabangela ukungazi kahle owaziyo njenge-IBS. Lezi zimpawu zivela ezindaweni ezine ezihlobene phakathi:
I-Post-Infectious IBS
Ubufakazi buqala ukukhuphuka okubonisa ukuthi i-IBS ivela kwabanye abantu ngokulandela ukutheleleka kakhudlwana kwebhaktheriya ohlelweni lokugaya . Ucwaningo lwabantu abanobuchopho obunjalo buye bathola ukuthi cishe ama-25% azoqhubeka nokuzwa izimpawu ze-GI ezingathandeki ezinyangeni eziyisithupha emva kokugula kokuqala.
Okuphazamisa okunye ukutholakala ukuthi umuntu oyedwa kwabangu-10 abathola ukutheleleka okukhulu kwe-GI uzophela ngesifo esiqhubekayo esibizwa ngokuthi i-IBS. Kulezi zimo, kukhona ukuhlonza isixhumanisi esicacile ekuguleni okukhulu kokugaya, kuhlukaniswe njenge-IBS-IBS-PI elandelwayo.
Ukucwaninga kweLab kunikeza izinkomba ezithile eziphathekayo mayelana ne-IBS-PI. Ukusebenzisa inqubo lapho izicubu zethala le-rectum zihlelwe khona, abaphenyusi bathole amanye amangqamuzana ahlobene nokuvuvukala kanye ne-serotonin emathanjeni angama-rectal abantu abathuthukile i-IBS. Lokhu kunikeza ubufakazi obengeziwe bendima yokuvuvukala kanye nokuxhumeka kobuchopho-ubundlu ekugcineni kwezimpawu ze-IBS.
Ama-probiotics
Ubufakazi obengeziwe bokubandakanya kubhaktheriya ku-IBS buvela ekusebenzeni kwama-probiotics ekunciphiseni izimpawu. Ama-probiotics ayaziwa ngokuthi "anobungane" amabhaktheriya ngoba acatshangwa ukuthi ayasiza empilweni yakho yokugaya ukudla. Nakuba iningi lemibiko yokusizwa kwama-probiotics we-IBS livela emibikweni ye-anecdotal, uhlobo oluthile lwe-probiotic, i-Bifidobacterium infantis iboniswe ngemitholampilo ukunciphisa izimpawu ze-IBS. Kucatshangwa ukuthi ukuthatha isithasiselo se-probiotics kusiza ukubuyisela amabhaktheriya ngaphakathi kwe-flora yamanzi ukuya esimweni esingcono kakhulu sokulinganisela.
Ukukhukhulwa Kwebhaktheriya Okuncane Kwezinambuzane (SIBO)
Ukwanda okukhulu kwamagciwane emathumbu (SIBO) yisimo lapho kunenombolo ephakeme kakhulu yebhaktheriya emathunjini amancane. Ithiyori entsha neyinkinga ethile ifuna ukukhomba iSIBO njengesisusa esiyinhloko se-IBS .
Abaxhasi be-SIBO theory bakholelwa ukuthi i-SIBO ibeka uphawu lwe-bloating, izinguquko ku- motility eziholela ekuhuleni nasekuqotheni, kanye ne- visceral hypersensitivity ebonwe iziguli ze-IBS.
I-SIBO ngokuvamile ihlolwe ukuthi isebenzisa ukuhlolwa okulinganisa inani lika-hydrogen emoyeni olandela ukungenisa iziphuzo eziqukethe i-lactulose. I-Lactulose yishukela engaxhunyiwe ngemizimba yethu, ngakho-ke ifakwa yi-bacteria ngaphakathi kwesimiso somzimba. Uma inani lokuphefumula kwe-hydrogen liphakeme isikhathi esifushane ngemuva kokuphuza isisombululo se-lactulose, kukholakala ukuthi kubonisa izinga eliphezulu kakhulu lama-bacteria ngaphakathi kwamathumbu amancane.
Impikiswano ikhona ngokwemibono ephikisanayo mayelana nokunemba kokuhlolwa kokuphefumula kwe-hydrogen, kanye nemibiko ephikisanayo mayelana nokuthi zingaki iziguli ze-IBS ezikhiqiza umphumela wokuhlola okungavamile. Njengamanje, isiphetho ngaphakathi kwenkampani ye-IBS ucwaningo ukuthi i-SIBO ingaba yindawo efanelekile yegciwane le-IBS.
Ama-antibiotics
Enye yocwaningo ebonisa ukuthi ama-bacteria asegulini adlala ingxenye ku-IBS iziqu kusukela ku-theory ye-SIBO kanye nokusetshenziswa okuphumelelayo kwemithi ethile yama-antibiotics njengokwelashwa kwe-IBS. Kusetshenziswa ama-antibiotics amabili, i-Rifaximin ne-Neomycin, ne-Rifaximin ebonisa ukuthi kunqenqemeni oluncane ngokusebenza. Lawa ma-antibiotic akhethwe ngoba awaxhunyiwe esiswini, ngakho-ke acatshangwa ukuthi angakwazi ukuhlasela noma yikuphi amabhaktheriya ahlala ngaphakathi emathunjini amancane. Ucwaningo lubonise ukuthi lezi antibiotics ziholela ekuthuthukiseni uphawu oluphawulekayo futhi zingase zihlotshaniswe nezinguquko ezinhle ekuhlolweni kokuphefumula kwe-hydrogen. Ukuhlukunyezwa ekusetshenzisweni kwama-antibiotic kuhlobene nezindleko zabo eziphezulu kanye nokukhathazeka ukuthi bafaka isandla ekuthuthukiseni izinhlobo eziningi ezingamelana nama-bacterium. Ama-antibiotics ayomelwe kuphela kubantu abathile ukuhlolwa kwesimo se-hydrogen kubonisa ukuba khona kwe-bacterial overgrowth emathunjini amancane.
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