Esikhathini esedlule, imishanguzo yokwelashwa yokwelapha ukuqashwa okungapheli nokuqothulwa-isifo esiyinkimbinkimbi yesifo sofuba (IBS-C) sasinganiselwe. Ngenhlanhla, lokhu kuyashintsha futhi iningi lemithi yokwelashwa iyatholakala ngokuphathwa kokuqedwa okungapheli.
Amitiza (lubiprostone)
I-Amitiza ivunyiwe yi-FDA yokwelashwa kwe-IBS-C, kanye nokuqokwa okungapheli kwe-idiopathic (CIC).
I-Amitiza isebenza ngokukhulisa inani lamanzi asemathunjini futhi ngaleyo ndlela ilulaze ukuhamba kwezihlalo.
Le mithi isebenza ezingeni lamaselula njengoba lihlose (lishukumisa) amaprotheni ahilelekile ekuthumeni i-chloride, ngakho-ke u-Amitiza uyaziwa njengomshicileli wesiteshi se-chloride. Abantu abaningi abathatha ama-Amitiza bazokwazi ukuthola ukuphumula kwesibonakaliso zingakapheli amahora angu-24.
Akufanele uthathe i-Amitiza uma unesithiyo sokuvimbela isisu , uthola isifo sohudo esinamandla, noma ukhulelwe noma uncelisa.
I-Lactulose
I-Lactulose iyi-laxative ye-osmotic esetshenziselwa ukwelashwa kokuqokwa. Kuthengiswa ngaphansi kwamagama ahlukahlukene wegama. Lezi zihlanganisa uCephulac, Chronulac, Constilac, Cholac, Constulose, Duphalac, Enulose, Generlac, neKristalose.
I-Lactulose iyishukela esenziwe ngabantu eyenziwa yi-bacteria emathunjini, inqubo edonsa amanzi amaningi kukholoni. Lokhu kwanda emanzini kunciphisa, kwandise, futhi kuvamile ukubeka phansi.
Umthamo ophakeme we-stool usiza ukugqugquzela umbala we- koloni futhi ngaleyo ndlela ukhuthaza ukunyakaza kwamathumbu.
I-Lactulose ngokuvamile iphakanyiswa ukuthi isetshenziswe ngesikhathi esifushane. Lokhu akuyona into yokuqala yokukhetha udokotela ngoba ayibekezelelwanga kahle (kubangela ukubhuqa okuningi negesi) futhi akuvamile ukuphumelela kunamanye okukhethwa kukho.
Ngaphambi kokuthatha i-lactulose, qiniseka ukuthi udokotela wakho uyazi uma uhlelwe ukuhlinzwa, unesifo sikashukela, noma ukhulelwe noma uncelisa.
I-Linzess (i-linaclotide)
I-Linzess ivunyiwe yi-FDA yokwelashwa kwe-IBS-C ne-CIC. EYurophu, imithi ibizwa ngokuthi iConella futhi ivunyelwe ukwelashwa kwe-IBS-C.
Imithi ibhekwa njenge-guanylate cyclase-C agonist. Kucatshangwa ukuthi kusebenza ngokukhulisa inani lomswakama emathunjini amakhulu okubangelwa ukunyuka kwenani lokuhamba kwamathumbu nokunciphisa ubuhlungu besisu.
I-Prucalopride
I-Prucalopride ihlukaniswa njenge-5-HT agonist njengoba ivuselela ama-receptors we-neurotransmitter serotonin (5-HT). Ngeshwa, i-prucalopride ingakavunyelwe ukusetshenziswa kwe-FDA futhi ayitholakali e-US Itholakala eYurophu naseCanada, ngezinye izilinganiso emtholampilo wayo.
Miralax
Ngokungafani neminye imithi efihliwe kuleli khasi, i- Miralax ayidingi imithi . Kodwa-ke, odokotela bavame ukukhuthaza i-Miralax ngenxa yokusebenza kwayo ekunciphiseni ukudambisa. I-Miralax idonsela amanzi esitokisini, isilula futhi inciphise isifiso sokunyakaza kwamathumba.
I-Zelnorm (i-tegaserod)
I-Zelnorm imithi eyakhelwe ukuphatha i-IBS-C ne-CIC.
Isebenza futhi ngokukhulisa inani le-neurotransmitter serotonin emaqenjini wesistimu yesifo sezinzwa .
Ngenxa yokuthi izingozi zempilo ezibucayi zihlonziwe, imithi itholakale ngesikhathi esiphuthumayo. Umshwalense wayo kumele ugunyazwe ngqo yi-FDA.
Inothi Mayelana Nezinkinga Zokucindezeleka
Ama-antidepressants awavunyelwe njengokwelashwa kokuqotshwa. Kodwa-ke, ngenxa yezinga eliphezulu lokucindezeleka ezigulini ezine-IBS nokuthi iqiniso lokuthi izidakamizwa ezidinga ukucindezeleka zingaba nezindawo zokulwa nobuhlungu obuphumelelayo, udokotela angase anikeze umuntu ocindezelayo umuntu obhekana ne-IBS-C .
Ama-anti-depressants akhethiwe kumuntu ohlangabezana nokuqotshwa kuzovela ekilasini okuthiwa i-serotonin reuptake inhibitors (SSRIs) ekhethiwe.
Lezi zincane kakhulu ezingabangela ukuqotshwa. Izibonelo zama-SSRI zihlanganisa uCelexa, Lexapro, Prozac, Paxil, ne-Zoloft.
> Umthombo:
> Ford A, et.al. I-American College ye-Gastroenterology Monograph ekuphathweni kwe-Irritable Bowel Syndrome ne-Chronic Idiopathic Constipation . I-American Journal ye-Gastroenterology. 2014; 109: S2-S26. doi: 10.1038 / ajg.2014.187
> Ukuphathwa kwe-US Nokudla Nezidakamizwa. I-Zelnorm (i-tegaserod maleate) Ulwazi. 2016. https://www.fda.gov/Drugs/DrugSafety/ucm103223.htm.