I-hormone yokukhula komuntu idlala indima eminingi emzimbeni, futhi ukuntuleka kwayo kungaholela ekukhuleni kwe- cholesterol ephakeme kanye nezinga eliphezulu le-LDL le-cholesterol. Ukuhlukumeza ngokobuciko kweHGH ngamathikithi ngaphandle kokushiyeka kungase kube inkinga.
UkuHlelwa KwamaHlomu Okuthinta Abantu Kuthinta Kanjani Amazinga E-Cholesterol?
I-hormone yokukhula yomuntu (i-HGH noma i-GH) yikhemikhali eyenziwa yi-pituitary gland ebuchosheni bakho.
I-HGH igqugquzela ukukhula kwethambo ebuntwaneni, ivumela izingane ukuba zikhule zibe ukuphakama kwabantu abadala. Ngaphezu kwalokho, kusiza umzimba ukubhubhisa ama-molecule amaningi we-lipid futhi ususe egazini kanye ne-triglycerides.
I-HGH iphinde iqhaza ekuvuseleleni ukukhiqizwa kwamaprotheni, ekuphikeleni i-insulini egazini kanye nokusiza umzimba ukuthi ugcine ama-electrolyte, kuhlanganise ne-phosphate, i-sodium, namanzi.
Ukuntuleka kwe-HGH
Umzimba wakho ukhiqiza i-HGH empilweni yakho kuqala ngaphambi kokuzalwa nokufinyelela amazinga okuphakama okuzungeze ubusuku. Ukukhiqizwa kwe-HGH kuyancipha kancane kancane kulo lonke umuntu omdala. Ngezinye izikhathi i-pituitary gland ingasebenzi futhi umzimba awukhiqizi okwanele kule hormone. Uma lokhu kwenzeka ebuntwaneni, ukukhula okujwayelekile kungathinteka. Lapho usukhulile, umphumela ovame kakhulu ukuguqulwa komzimba, ngezinga eliphakeme lamanqamu omzimba kanye nesisindo somzimba esincane. Kubantu abadala, imbangela eyinhloko yamazinga aphansi e-HGH yi-tumor emthonjeni we-pituitary.
Ukuhlinzwa kwebongo kungaphazamisa ukukhiqizwa kweHGH.
Ukuntuleka kwe-HGH kubantu abadala kuyinto engavamile kakhulu. Ucwaningo olwenziwa ngo-1999 olugxile ekuntulekeni kwe-HGH eFrance luthi abantu abangu-12 kwabangu-1 million (0.0012%) banenkinga. Phakathi kwezingane, ukwehluleka okunjalo kuvame kakhulu, kodwa kusengavamile, okwenzeka ezinganeni ezingaba ngu-2.4 kwabangu-100 000 (0.0024%).
Yeka ukuthi i-HGH ephansi kanjani ethinta i-cholesterol
Ngaphezu kokukhulisa amazinga amafutha agcinwe emzimbeni nasezingeni eliphansi lokumisa imisipha, amazinga aphansi e-HGH nawo aholela ekukhuleni kwe-cholesterol ephelele, isifo senhliziyo, isisindo samathambo aphansi, sashintsha umsebenzi wengqondo futhi ingozi enkulu yokufa jikelele.
Ngaphezu kokushintsha kokulingana kwamandla omzimba omzimba omzimba omzimba, abantu abane-HGH abangenalutho abangenalutho banamazinga aphakeme "we-cholesterol embi" (i- LDL ) uma kuqhathaniswa nabanye abantu. Leli fomu le-cholesterol lijwayele ukunamathela ezindongeni ze-artery, nokwenza amapulethi enza uhlobo lwezinzwa zenhliziyo ezibizwa ngokuthi i- atherosclerosis . Ama-plaque atherosclerotic angahle aphule, aqhube ama-blood clots futhi angavimbela ukugeleza kwegazi enhliziyweni noma ebuchosheni, obangela ukuhlaselwa yinhliziyo noma ukushaya isisu.
Imiphumela ye-HGH Injections ku-Cholesterol
I-HGH ingashintshwa nge-injection ye-synthetic growth hormone eyaziwa njenge-recombinant human growth hormone (rHGH). Lezi zijovo zitholakale ukugqugquzela ukukhula ezinganeni, ukwandisa umthambo wezinhlungu ezikhukhulayo kuzo zombili izingane kanye nabantu abadala, futhi kuthuthukiswe ezinye izici ezithintekayo ngamazinga aphansi e-HGH.
Ngenxa yokuthi ikwazi ukukhulisa isisindo somzimba, i-rHGH ngezinye izikhathi iye yahlukunyezwa ngabagijimi nabanye abafuna ukushintsha ukubonakala kwabo komzimba nokuthuthukisa ukusebenza kwezemidlalo.
Ngeshwa, njengoba lolu hlobo lokusetshenziswa luvame ukufihla, odokotela nososayensi abanalo ulwazi oluningi ngemiphumela emihle noma emibi, kubandakanya umthelela we-cholesterol nenengozi yempilo ye-rHGH ukusetshenziswa ngabantu abanezigaba ezivamile ze-HGH.
Ukucwaninga ngomthelela we-rHGH nge-cholesterol kuhlanganisiwe. Ezinye izifundo zithole ukuthi i-hormone yokwenziwa ayishintshi amazinga e-cholesterol, kuyilapho abanye baye babonisa ukwehla kwamaningi "ama-cholesterol amabi". Ucwaningo olulodwa lwabonisa ukwehla kokubili "ama-cholesterol amabi" namazinga ephelele we-cholesterol ezinyangeni ezintathu zokuqala, kodwa ngemuva kwalokho ukusetshenziswa okuqhubekayo kwamazinga e-cholesterol abahlanganyeli be-rHGH babuyele lapho bebekhona ngaphambi kokuqala ukujova kwama-hormone.
Ezinye izifundo ziye zabika imiphumela emibi yokusetshenziswa kwe-rHGH, kufaka phakathi amazinga aphezulu we- lipoprotein (a) . Njengoba "nge-cholesterol embi," amazinga aphezulu we-lipoprotein (a) anegalelo ekutheni ama-atherosclerotic plaques asezindongeni ze-artery. Kodwa-ke, ucwaningo lubonisa ukuthi i-rHGH yehlise amazinga egazi weprotheyini esebenzayo (CRP), futhi ukunciphisa amazinga e-CRP kubonakala njengesibonakaliso sokunciphisa ingozi yezinkinga zenhliziyo.
Abantu abathatha i-rHGH kufanele benze njalo njengoba kunqunywe udokotela wabo noma udokotela. Kufanele futhi baqiniseke ukuthi balandele amazinga abo e-cholesterol ngoba amazinga aphansi e-HGH angakhuphula kakhulu amazinga e-cholesterol. Abanye abantu abathatha i-rHGH nabo bangadinga imithi yokwehliswa kwe-cholesterol, njenge-statin, ukwehlisa amazinga e-cholesterol nokunciphisa ingozi yokuba nesifo senhliziyo noma isifo sohlangothi.
Labo abasebenzisa i-rHGH ngaphandle kweseluleko somhlinzeki wezempilo onelayisense kufanele baqaphele ukuthi le hormone ingaba nemiphumela ephawulekayo (futhi engaba yingozi) kumazinga we-cholesterol nenempilo yenhliziyo. Nakuba ukwelashwa kwe-RHGH kungabasiza abantu abanezinga eliphansi lemvelo le-HGH, ochwepheshe abazi imiphumela ye-cardiovascular noma ezinye izici ze-rHGH ezisetshenziswa kulabo abanezinga elijwayelekile le-HGH.
Imithombo:
Ama-Bates, AS, et al. "Umphumela We-Hypopituitarism Ekuphileni Okulindelwe." I-Journal ye-Endocrinology Clinic ne-Metabolism 81 (1996): 1169-72.
I-Baum, HB, et al. "Imiphumela ye-Physiologic Growth Hormone Therapy on Bone Mass and Body Composition in Patients With Growth-Onset Growth Ukuntuleka KwamaHlomu: Isivivinyo Esingahleliwe, Isimo Esilawulwa Ngendawo." Ama-Annal of Medicine Internal 125 (1996): 883-90.
Bengtsson, BA, et al. "Ukwelashwa Kwabantu Abadala Nge-Growth Hormone (GH) Ukuntula Nge-Recominant Human GH." Journal of Endocrinology Clinic and Metabolism 76 (1993): 309-17.
Biller, BM, et al. "Ukuhoxiswa kwe-Long-Term Physiological Growth Hormone (GH) Yokuphatha: Imiphumela Ehlukile kwi-Bone Monitoring and Body Composition in Men With Adult-Gset Inselele GH." I-Journal of Endocrinology Clinic kanye neMetabolism 85 (2000): 970-6.
UCarroll, uPV, et al. "Ukukhula KwamaHormone Ekukhuleni Kwabantu Abadala kanye Nemiphumela Yokukhula KwamaHlmone esikhundleni: Ukubuyekezwa." Journal of Endocrinology Clinic and Metabolism 83 (1998): 382-95.
Koranyi, J., et al. "Izindlela ezisemqoka kanye nemiphumela emihlanu ye-GH Yokuguqula Indawo Yokwelashwa Kubantu Abadala abane-GH Ukuntula Ubuntwana Noma Ukukhula Kwabantu Abadala: Isifundo Esiqhathanisayo, Esifunayo." I-Journal ye-Endocrinology Clinic ne-Metabolism 86 (2001): 4693-9.
UMelmat, uShlomo. "I-Physiology ye-Growth Hormone." UpToDate.com . 2015. UpToDate.
U-Rogol, u-Alan D. "Ukwelashwa Kokukhula KwamaHlomu Ezinganeni." UpToDate.com . NgoJuni, 2015. UpToDate.
Sassolas, G., et al. "GH Ukuntula Kubantu Abadala: Indlela Yokubhekana Ne-Epidemiological." I-European Journal of Endocrinology 141 (1999): 595-600.
Sesmilo, G., et al. "Imiphumela Yezokukhulisa AmaHormone Ukukhula Ngezifo Ezivuthayo Nokunye Amakhwaza Engozini Yezinhliziyo Emadodeni Anezikhukhula Ukuntuleka KwamaHlomu: Isivivinyo Esingahleliwe, Esilawulwa Ngokwelashwa." Ama-Annal of Medicine Internal 133 (2000): 111-22.
Snyder, Peter J. "Ukukhubazeka KwamaHhomu Okukhula KwamaHholo Kwabantu Abadala." UpToDate.com. 2015. UpToDate.
Snyder, Peter J. "Ukusetshenziswa kwama-Androgens nezinye izidakamizwa ngabadlali." UpToDate.com . 2016. UpToDate.
Stochholm, K., et al. "Ukukhubazeka kwe-GH Ukuntuleka - Isifundo Somhlaba Wonke." I-European Journal of Endocrinology 155 (2006): 61-71.