Indlela Esebenza Ngayo Ezimweni Ezivamile ze-PCOS Njengezinwele Ezibukeka Ngingafuneki
I-Polycystic i-ovary syndrome (i- PCOS ), isifo esivamile se-endocrine phakathi kwabesifazane abaneminyaka ekhulile, ibonakala nge-hyperandrogenism (amazinga aphezulu amahomoni wesilisa, afana ne-testosterone) nokungasebenzi komzimba ovulatory.
Ezinye zezimpawu ezicindezelayo kakhulu abesifazane abanesipiliyoni se-PCOS kuhilela izinwele: ukulahleka kwezinwele nokuboya umzimba (hirsutism). Imiphumela yocwaningo olwanyatheliswa ku-PLOS One, iphephandaba elibukeziwe ngontanga, lithole ukuthi i-hirsutism inomthelela oqine kakhulu kwizinga elihlobene nempilo yokuphila kwamantombazane ase-Iranian atholakala nge-PCOS.
Imiphumela ye-hirsutism ayithatha isikhathi esiningi sokuphatha, ithinta izinga lokuphila nokuzihlonipha.
Abesifazane abane-PCOS ababhekene nemiphumela ye- hirsutism bangase babekwe i-Flutamide, imithi esebenza njenge-anti-androgen.
Indlela Flutamide Imisebenzi
I-Flutamide (igama elivamile eli-Eulexin), lisebenza ngokuvimbela i-androgens, eyiqembu lama-hormone edlala indima emathweni wesilisa nomsebenzi wokuzala.
Amaphesenti angama-70-80 wabesifazane abanama-androgens amaningi abonisa i-hirsutism. I-Androgens yandisa izinga lokukhula kwezinwele futhi liguqule elifushane, elihle, elikhanyayo, izinwele zezinwele (izinwele ze-vellus) ezinxeneni ezinzima, ezide futhi ezibomvu. Uma i-androgens iyancishiswa, ukukhula kwezinwele ezintsha kuyancipha futhi ukukhula kwezinwele ezikhona ezikhona kuyancipha.
I-Flutamide ivimba ama-androgen receptors ezinqenqeni zezinwele zezinwele ngakho-androgens ayikwazi ukuxhuma kuma-receptors. Uma i-androgens e-follicle yezinwele ivinjelwe, ukulahlekelwa kwezinwele ezihlobene ne-PCOS kanye ne-hirsutism kunciphisa.
Lokhu kunganciphisa izimpawu ze-PCOS , ikakhulukazi ukukhula kwezinwele ezidlulele ezihambisana ne-PCOS, nakuba i-Flutamide engavunyelwe yi-FDA ngalolu hlelo.
Abesifazane abaningi abathatha i-Flutamide bayaqaphela izinwele ezinde kakhulu kanye nezinwele ezingaphansi komzimba nobuso. Isici esihle sePlutamide ukuthi akusiyo i-steroidal futhi ayithinti umsebenzi wezinso njengamanye ama-anti-androgens.
I-Flutamide ayisebenzi ngokushesha. Izinwele zikhula ngezikhathi ezahlukene futhi isigaba sokukhula sihluka ngokuya endaweni yomzimba, ukukhula okugcwele, lo mjikelezo wokukhula cishe izinyanga ezingu-4 ngezinwele zobuso. Yingakho kunconywa ukuthi unikeze ukwelapha okulwa no-androgen ngaphezu kwezinyanga ezingu-6 ukuze kusebenze ngokugcwele.
Isilinganiso kanye nemiphumela emibi
Umthamo ojwayelekile we-Flutamide we-PCOS ungama-125 mg noma ama-capsules ama-250 mg kabili ngosuku kathathu. Sicela ubheke izikhombisi-ndlela zakho zodokotela ukuze uthole inani elilinganiselwe lemali yesimo sakho. Njalo ulandele iseluleko sikadokotela wakho ngaphambi kokuqala noma imuphi umuthi wemithi.
Eminye imiphumela emibi ejwayelekile ye-Flutamide ihlanganisa:
- ukulala
- ukucindezeleka
- ukudideka
- isifo sohudo
- isiyaluyalu
- ukuhlanza
- ukushisa okushisayo
- ukulahlekelwa kwe-libido
- ukushayeka
- ukuvuvukala
- isikhumba esomile
- ukukhubazeka kokuzalwa
Lokhu akulona uhlu oluphelele lwemiphumela emibi kanti abanye bangase bavele. Xhumana nodokotela wakho uma uhlangabezana nanoma yimiphi imiphumela emibi elandelayo.
Ezinye Iziqondiso
Ukuhlolwa kwegazi njalo kunconywa ukuthi kuhlolwe umsebenzi wesibindi kanye negazi futhi kuvimbele uketshezi ekuthatheni i-Flutamide.
Kubaluleke kakhulu ukuthi ungakhulelwa ngenkathi uthatha i-Flutamide, ngenxa yengozi engase ibe yintombazane ekhulayo. Qinisekisa ukusebenzisa ifomu eliphumelelayo lokulawulwa kokuzalwa futhi ungalusisi ngenkathi uthatha lesi sidakamizwa.
Bika noma yimiphi imiphumela emibi engavamile kudokotela wakho ngokushesha.
Imithombo:
Ibanez L, Potau N, Marcos MV, de Zegher F. Ukwelashwa kweHirsutism, Hyperandrogenism, Gligomenorrhea, i-Dyslipidemia, ne-Hyperinsulinism e-Nonobese, Amantombazane ase-Adolescent: Imiphumela ye-Flutamide. J Clin Endocrinol Metab. 2000 Sep; 85 (9): 3251-5.
> Mahnaz Bahri Khomami, Fahimeh Ramezani Tehrani, Somayeh Hashemi, Maryam Farahmand, noFereidoun Azizi. Ezimpawu ze-PCOS, i-Hirsutism Inomthelela Oqakatheke Kakhulu Emgangweni Wokuphila Kwabesifazane base-Iranian. PLoS One. 2015; 10 (4): e0123608.
I-Muderris II, i-Bayram F, i-Guven M. Ukwelashwa kwe-Hirsutism Nge-Flutamide ephansi kunazo zonke (62.5 mg / ngosuku). I-Gynecol Endocrinol. 2000 Feb; 14 (1): 38-41.
I-Muderris II, i-Bayram F, i-Guven M. A Ebonakalayo, Isilinganiso Esingakahleleki Ukuqhathanisa i-Flutamide (250 mg / d) ne-Finasteride (5 mg / d) ku-Treatment of Hirsutism. I-Fertil Steril. 2000 Meyi; 73 (5): 984-7.