Abasebenzisi ababili be-NSAID bandisa ingozi yezindlela ezingezansi
Izidakamizwa ezingekho-steroidal anti-inflammatory (NSAIDs) ziyisisekelo esiyinhloko kubantu abaningi abane-arthritis. Kodwa ukuthatha imithi engaphezu kweyodwa kulesi sigaba akunikezi nje izinzuzo ezimbalwa kodwa kungaba yingozi kakhulu. Yiziphi ngempela i-NSAID, yiziphi izingozi, futhi yimiphi imithi efakiwe kulolu cwaningo ukuze uqinisekise ukuthi awuphindaphindi kabili esigabeni esifanayo semithi?
Yiziphi izidakamizwa ezingekho-steroidal anti-inflammatory (NSAIDs)?
Izidakamizwa ezingezona ukuvuvukala (ama-NSAID) yizigaba zezidakamizwa ezivame ukwenziwa ukuphatha i- arthritis .
Njengoba ama-NSAID atholakala kokubili ngogunyaziwe nangaphezu kwekhasi, abanye abantu baphela ukuthatha ama-NSAID amabili ahlukene.
Abantu bangase bakhethe ukuthatha ama-NSAID amabili ngenxa yokuphumula okungafanelekile noma ngenxa yokuthi abaqapheli ukuthi izidakamizwa zisesigaba esifanayo semithi yokwelapha. Ukusebenzisa ama-NSAID amabili ahlukene ndawonye kungaphephile futhi akusilo umqondo omuhle, ngoba ukwenza kanjalo kungandisa ingozi yemiphumela emibi engathandeki kanye nezenzakalo ezibi kakhulu.
Ama-NSAID adumile anengozi
Ungase ucabange ngokucasuka kwesisu njengomphumela ovamile wokuthatha imithi efana no-Advil, kodwa kunezimpendulo eziningana ezingahle zifanele ukuthi wazi.
Ukuphuma kwegazi: Izigidi zabantu zithatha i-NSAID nsuku zonke ngenxa ye-arthritis, ukulimala kanzima, kanye nezinqamuzana zokuya esikhathini.
Kucatshangwa ukuthi abantu abangaphezu kuka-100 000 baseMelika bayiswa esibhedlela kanti phakathi kuka-15 000 no-20 000 bayafa ngonyaka ngamunye kusukela ezilonda kanye nokuphuma kwegazi ngokuphathelene nokusetshenziswa kwe-NSAID. (Ukuze uqonde ubukhulu balokhu, abesifazane abangaba ngu-40 000 bafa ngomdlavuza wesikhumba unyaka ngamunye.) I-akhawunti ye-NSAID ngamaphesenti angama-60 wemigomo eminingi yokuthengwa komthengi ethengwe, futhi kubantu abasebenzisa ama-NSAID nganoma yisiphi isizathu, amaphesenti angama-2 kuya ku-GI azothola i-GI ukuphuma.
Ekhuluma kuphela nge-arthritis, iziguli eziyizigidi eziyi-14 zithatha ama-NSAID njalo-amaphesenti angama-60 azoba nemiphumela emibi yemiphumela yamathumbu njengomphumela. Ingozi iphezulu kulabo asebekhulile, abathatha ama-aspirin noma abaxhasi begazi, abathatha izinhlobo ezithile namanani we-NSAID, futhi uma imithi engaphezu kweyodwa kulesi sigaba isetshenziswa.
Ukuhlaselwa kwenhliziyo nokulimala komzimba: Ukusetshenziswa kwe-NSAID kuhlotshaniswa nengozi eyengeziwe yokwehla kwesifo senhliziyo noma isifo sokushaya isifo esingaholela ekufeni-futhi ingozi ikhuphukela iziguli ezisebenzisayo isikhathi eside noma isifo senhliziyo. Kunezinye ze- NSAID ezithwala ingozi yomzimba kunabanye, futhi kubalulekile ukuthi ukhulume nodokotela wakho ngokubili izimpawu zakho ze-arthritis nomlando wakho womuntu siqu noma womndeni wezinhliziyo zenhliziyo kanye nezici eziyingozi. Imithi ebizwa ngokuthi i-Vioxx imithi yayisuswe emakethe lesi sizathu.
Ukulimala kwezinso: Ngisho nokulinganisa okujwayelekile kwama-NSAID asetshenziselwa izimo ezincane kungabangela ukulimala okunzima kwezinso ( ukungaphumeleli kwe-renal acute .) Emhlabeni wonke kulinganiselwa ukuthi abantu abayizigidi ezingu-2,5 bahlangabezana nokungaphumeleli kwe-renal ngenxa ye-NSAID njalo ngonyaka.
Izincomo Zokusetshenziswa Okuphephile kwama-NSAID
I-FDA itusa ukuba ukusetshenziswa okuphephile kwama-NSAID, imithi kufanele ithathwe:
- Kuphela njengoba kunqunyiwe
- Ngomthamo ophansi kunazo zonke osebenzayo
- Ngesikhathi esifushane esidingekayo
Kuye kwabikwa ukuthi abantu bavame ukubika ukuthi basebenzisa kanjani ama-NSAID angaphezu kwe-counter. Ucwaningo luye lwabona ukuthi abantu abangabikeli ukusetshenziswa kwe-NSAID ukusetshenziswa kokukholelwa ukuthi izidakamizwa azibalulekile ngoba zitholakala ngaphandle kwemithi. Lokhu akulona iqiniso futhi kungesinye sezizathu (kuningi) kungani abantu kufanele babonise udokotela wabo nganoma yisiphi isisindo esingaphezu kwe-counter noma ukudla okuthandayo.
Ukuhluleka ukutshela udokotela we-over-the-counter ukusetshenziswa kwemithi kungenye yezizathu lapho abantu ngezinye izikhathi beqeda ukusebenzisa izidakamizwa ezimbili kulesi sigaba nakuba kungaba yingozi.
Ukuthatha ama-NSAID amabili kunengozi
Ingozi ekhulayo ehlobene nokuthatha ama-NSAID amabili kubalulekile. Ukutadisha okudala okushicilelwe kuyi- European Journal of Clinical Pharmacology kwaphetha ngokuthi ingozi yokubhekana nezidakamizwa ezinamandla okwenza ukulimala kwesibindi nokuhluleka okukhulu kwe-renal kwakunezikhathi ezingu-6 kuya kwezi-7 eziphakeme ezikhulwini ezibikiwe zokusetshenziswa ngesikhathi esisodwa kwama-NSAID amabili. Kodwa ngisho nalokhu kwaziswa, ingozi ihlala. Ucwaningo lwango-2017 lwathola ukuthi phakathi kwabantu abadala asebekhulile bethatha ama-NSAID, ukusetshenziswa okungalungile kwafunyanwa ngamaphesenti angu-70.
Ungavumeli lokho kwenzeke kuwe. Sebenzisa ama-NSAID ngokuphepha nangokufanele. Uma usuvele uthatha i-NSAID kadokotela, hlola nodokotela wakho ngaphambi kokuba uthathe imithi ephikisayo.
Izidakamizwa zibizwa ngokuthi yi-NSAIDS
Ukuze ugweme ukuthatha i-NSAID engaphezu kweyodwa, kubalulekile ukwazi ukuthi yiziphi izidakamizwa ezifakiwe kuleli klasi. Kubalulekile futhi ukuqaphela ukuthi imithi ejwayelekile ingathengiswa ngaphansi kwamagama amasha ahlukahlukene. Isibonelo, ibuprofen imithi ejwayelekile ku-Advil, Motrin, Nurofen, nabanye. I-NSAID ingabuye ihlanganiswe neminye imithi.
Kunezinhlobo ezintathu eziyinhloko zama-NSAID. Lezi zihlanganisa ama-salicylates (kokubili acetylated njengama-aspirin angama-acetylated,) ama-NSAID yendabuko (njenge-Advil,) nama-inhibitors e-COX-2, njenge-Celebrex. Ama-NSAID avame ukusetshenziselwa ukwelapha i-arthritis afaka:
- I-Actron (ketoprofen)
- I-Aleve (naproxen)
- I-Anaprox (naproxen)
- I-ansaid (flurbiprofen)
- I-arthrotec (i-diclofenac ne-misoprostol)
- I-aspirin (i-acetylsalicylic acid)
- U-Advil (ibuprofen)
- I-Cataflam (i-diclofenac potassium)
- I-celebrex (i-celecoxib)
- I-Clinoril (i-sulindac)
- I-Daypro (i-oxaprozin)
- I-Disalcid (i-salsalate)
- I-Dolobid (i-diflunisal)
- UFeldene (piroxicam)
- Ibuprofen (amagama angama brand ahlanganisa uMotrin, Advil, Mediprin, Nuprin, Motrin IB)
- Indocin (indomethacin)
- Ketoprofen (amagama amagama ahlanganisa i-Orudis, i-Oruvail, i-Actron, i-Orudis KT)
- I-Lodine (etodolac)
- I-Meclomen (i-meclofenamate sodium)
- I-Mobic (meloxicam)
- I-Motrin (ibuprofen)
- I-Nalfon (i-fenoprofen)
- I-Naprelan (naproxen)
- I-Naprosyn (naproxen)
- I-Naproxen (amagama omuthi afaka iNaprosyn, i-Aleve, i-Naprelan, i-Anaprox)
- I-Orudis (ketoprofen)
- I-Oruvail (ketoprofen)
- I-Ponstel (i-mefanamic acid)
- I-Relafen (nabumetone)
- I-Tolectin (i-tolmetin sodium)
- Hlanganisa (choline trisalicylate ye-magnesium)
- I-Voltaren (i-diclofenac sodium)
Ngezansi kokuthatha okungaphezulu kweNSAID eyodwa
Ukuthatha i-NSAID engaphezu kweyodwa kuncane ukuthuthukisa ukulawulwa kobuhlungu, kodwa kwandisa kakhulu ingozi yemiphumela emibi ejwayelekile kanye nokuphendula okubi. Lokho kusho ukuthi abantu abaningi kakhulu baqeda ukusebenzisa imithi engaphezu kweyodwa ngesikhathi. Ingxenye yenkinga ukuthi le mithi itholakala kokubili ngemithi kadokotela kanye ne-over-the-counter, futhi uma udokotela wakho engazi ukuthi imithi engayinqangi uyayithatha, iphutha lingase lingabonakali.
Ngaphezu kokuphindaphindiwe kuma-NSAID, kunemiphumela emibi eminingi engase ibe khona kanye nokusebenzisana phakathi kwemithi abantu abayisebenzisela i-arthritis. Indlela engcono kakhulu yokunciphisa amathuba okuba nomthelela omubi ukuxoxa ngokucophelela ngemithi ngayinye oyithatha ngayo kokubili udokotela wakho kanye nomklami wakho. Njengoba amaphutha ezokwelapha ehlelwa njengesizathu sesithathu sokufa e-United States, kufanele ukhohlwe.
> Imithombo:
> Kasper, uDennis L .., u-Anthony S. Fauci, noStephen L .. Hauser. Izimiso zikaHarrison zeMithi yangaphakathi. ENew York: imfundo kaMc Graw Hill, 2015. Print.
> Luciano, R., noM. Perazella. Ama-NSAID: Ukulimala Okunamandla Kwezinso (Ukungaphumeleli Okunamandla Kwe-Renal). UpToDate . Kubuyekezwe 03/01/17.
> Sostres, C., Gargallo, C., noL. Angel. Izidakamizwa eziphikisayo ezingezona ukuvuvukala kanye nokulimala okuphansi kweMastosal kwe-Gastrointestinal Mucosal. I-Arthritis Research and Therapy . 2013. 12 (I-Suppl 3): S3.