Abaningi besifazane bayothola izimpawu ezingathandeki ezinsukwini ngaphambi kwesikhathi sabo. Lezi zimpawu zingabandakanya ukushintsha kwemizwelo noma ukuzwa kancane kancane.
Kodwa, uma ubhekene nezinguquko ezinzima zemizwa ehlala njalo ezinsukwini ezingu-7 kuya kwezingu-14 ngaphambi kwesikhathi sakho bese uhamba ngokuphelele phakathi nezinsuku ezimbalwa zokuqala zokuphuma kwegazi unayo isifo sokugula esisengaphambili (PMDD) .
I-PMDD iyinkinga ye-Mood
Isiyaluyalu somzwelo sicatshangwa ukuthi siwumphumela wokuphazamiseka okushintsha ingqondo yakho ye-neurochemistry kanye nama-circuit circuits. Singase singaqondi ngokuphelele indlela imizwa yakho ilawulwa ngayo, kodwa siyazi ukuthi ukulawulwa kwemizwa yakho kusengqondweni yakho. Ucwaningo luye lwabonisa ukuthi imizwa yakho yimbangela yokusebenzisana okuyinkimbinkimbi phakathi kwezakhiwo zobuchopho, izifunda zengqondo, namakhemikhali akho obuchopho noma ama-neurotransmitters.
Okubangela ukuguqulwa kobuchopho obangela ukukhathazeka kwemizwelo kuyindawo yokuphenya okusebenzayo. Imiphumela yezifundo zamanje zikhomba izimbangela eziningana zezimbangela zokukhathazeka kwemizwelo, kuhlanganise:
- Izimbangela zofuzo
- Ukucindezeleka
- Imithi
- Izimo zokwelashwa ezingapheli
Uma unenkinga ye-PMDD, imbangela yesifo sakho sengqondo sinezingqimba eziyinkimbinkimbi: amahomoni akho okuzala.
Okuthi Siyazi Ngomphumela We-PMDD
Amahomoni akho wokuzala, okuyi-estrogen, ne-progesterone, asebenzisana namakhemikhali akho obuchopho futhi angathonya imisebenzi ethile ebuchosheni bakho, kuhlanganise nomzwelo wakho.
I-Estrogen ne-progesterone zikhiqizwa ama-ovaries akho futhi amazinga ala ma-hormone aguquke ngesikhathi sokujikeleza njalo.
Lezi yizinguquko ezijwayelekile ze-hormonal ezitholwa yibo bonke abesifazane, kodwa akubona bonke abesifazane abahluphekayo yi-PMDD. Ngakho-ke, kukhona okuhlukile okuqhubekayo kumaphesenti amathathu kuya kwangu-8 abesifazane abano-PMDD.
Uma une-PMDD awunawo ukungalingani kwe-hormonal noma ukuntuleka. Esikhundleni salokho, kucatshangwa ukuthi ungase uzwele kakhulu izinguquko ze-hormone ezijwayelekile zomjikelezo wakho wokuya esikhathini.
Lokho esingakakuqondi ngokugcwele yilokho okubangela ukuthi uzwela.
I-Progesterone / i-Allopregnanolone
I-criteria enkulu yokuxilongwa ye-PMDD yukuthi izimpawu zakho zilinganiselwe esigabeni sokugcina sokujikeleza kokuya esikhathini. Isigaba sokwehlukanisa yisikhathi phakathi kwe-ovulation nosuku lokuqala lwenkathi yakho. Ngomjikelezo ojwayelekile osukwini lwezinsuku ezingu-28 lokhu kuhambelana nezinsuku zokujikeleza ezinsukwini ezingu-14 kuya ku-28.
Ekuvuthweni, ama-ovari akho aqala ukwandisa ukukhiqizwa kwawo kwe-progesterone. I-progesterone ishintshwe ibe enye i-hormone ebizwa ngokuthi i-allopregnanolone (i-ALLO). Ama-progesterone nama-ALLO aqhubeka evuka kuze kube yilapho uqala isikhathi sakho, lapho ephumula ngokushesha. Enye ingqondo ukuthi uma une-PMDD uzwela kakhulu lokhu kuhoxiswa kwe-progesterone.
Enye ingqondo ukuthi u-ALLO unomthwalo wemfanelo kakhulu ngenxa yokuthi uxhumana ne-GABA receptors ebuchosheni bakho. I-GABA iyimithi ejwayelekile yengqondo noma i-neurotransmitter ukuthi, uma iboshelwe ezithombeni zayo ezibuchopho, ilawula ukukhathazeka nokukhathazeka. Eqinisweni, isizathu sokuthi utshwala kanye ne-benzodiazepines ziyi-anxiolytic futhi zihlala kanjani ukuthi zibophezela kwi-GABA receptors ebuchosheni bakho futhi zenze njengeGABA yakho yobuchopho.
Ngokuvamile, i-ALLO isebenza ebuchosheni bakho njengotshwala kanye ne-benzodiazepines.
Kodwa kwabesifazane abane-PMDD kucatshangwa ukuthi kukhona okungafani nokusebenza okuvamile kwe-ALLO. Enye kungenzeka ukuthi kukhona ushintsho ekuzweleni kwe-GABA receptor kuya ku-ALLO esigabeni esilandelayo. Noma, mhlawumbe kunesici ekukhiqizeni kwesigaba se-luteal sika-ALLO. Lokhu ukungasebenzi kwe-ALLO kungabangela ukukhathazeka okwandayo, ukucasula, nokuhlukunyezwa kwe-PMDD.
I-Estrogen
Nakulokhu, lapho uzama ukuveza ukuthi izimbangela ze-PMDD zikhona, kubalulekile ukukhumbula ukuthi i-PMDD ivele kuphela ngesikhathi sesigaba sokuqala sokuhamba esikhathini.
Ngemuva kwe-ovulation, lapho amazinga e-progesterone ephakama, amazinga e-estrogen akho awela. Lokhu kwehla okusheshayo ezingeni lakho le-estrogen kungenye imbangela ye-PMDD.
Siyazi ukuthi i-estrogen ihlangene namakhemikhali amaningana obuchopho alawula isimo sakho sengqondo. Enye yalezi zimakhemikhali zobuchopho ibizwa ngokuthi i-serotonin. I-Serotonin idlala indima enamandla emzimbeni wakho ngokugcina umqondo wakho wenhlalakahle. I-Serotonin ihilelekile ekulawuleni imisebenzi eminingi, kufaka phakathi isimo sakho sengqondo, ukulala nokudla. I-Serotonin nayo ithonya ukuqonda kwakho, noma ukuthi uthola kanjani, usebenzise futhi uthola ulwazi oluvela kwimvelo yakho.
I-Estrogen ikhuthaza imiphumela emihle ye-serotonin. Kucatshangwa ukuthi uma une-PMDD, isistimu yakho ye-serotonin ingase izwele kakhulu ukwehla okuvamile ku-estrogen ngesikhathi sesigaba sokuhamba komjikelezo wakho. Ngamanye amazwi, uma une-PMDD ukwehla okuvamile kwi-estrogen ngesikhathi sesigaba sokuqamba komjikelezo wakho wokuya esikhathini kungabangela ukwehla okukhulu ngokweqile kumazinga we-serotonin ebuchosheni bakho. Amazinga e-serotonin aphansi ahlotshaniswa nemizwa ecindezelekile, izifiso zokudla, nokukhubazeka kokusebenza kwengqondo kwe-PMDD. Lokhu kutholakala kusekela ukusetshenziswa kwe-serotonin receptor inhibitors (i-SSRIs) yokuphatha i-PMDD.
Ukucindezeleka
Uma une-PMDD kungenzeka ukuthi unomlando womuntu siqu wobungane ngokomzimba, ngokomzwelo, noma ngokocansi. Abanye, kodwa hhayi bonke, abesifazane abane PMDD banomlando wokuvezwa okukhulu kokucindezeleka.
Abacwaningi babheka ukuthi lo mlando wokucindezeleka ungaholela kanjani ku-PMDD. Enye indlela ebukeka ithembisayo ubuhlobo phakathi kokuphendula kokucindezeleka kanye ne-ALLO. Ngokuvamile, i-ALLO ikhula ngezinye izikhathi zokucindezeleka okunzima, isebenzisa ukukhubazeka kwayo okuvamile nokudambisa. Ucwaningo lokuhlola lubonise ukuthi impendulo ka-ALLO ekucindezelekeni okujulile iyancipha uma ibhekene nokucindezeleka okungapheli.
Ukuqonda ukuthi ukucindezeleka kungaholela kanjani noma kuphuthumise izimpawu ze-PMDD okwamanje kuyindawo yokuphenya okusebenzayo. Ngokuqinisekile, kungenzeka ukuthi uxhumano phakathi kwempendulo yakho yokucindezeleka kanye ne-PMDD lusekela ukuphazamiseka kokuqala kokwelashwa kwemigqa ye-PMDD, kuhlanganise nokuguqulwa kwendlela yokuphila nokunciphisa ukucindezeleka.
Ukusebenza kwe-Immune / Ukuvuvukala
Kukhona ubuhlobo obuhle obuphakathi kokucindezeleka nokusebenza kwesistimu yakho yomzimba. Nakuba i-PMDD ixilongwa ngendlela ehlukile kunenkinga enkulu yokucindezeleka (MDD), kungase kube nendima ethile ukuthi impendulo yakho yegciwane lengculaza ingabamba iqhaza ku-PMDD.
Ngenxa yezinguquko ezivamile ezimpikeni zokuzivikela ezikhukhumayo nezokuvuvukala phakathi nomjikelezo ojwayelekile wokuya esikhathini, abesifazane abanezimo ezithile zokuvuvukala ezifana ne-gingivitis nesifo sofuba esifubeni bangase babone ukuwohloka kwezibonakaliso zabo esigabeni esilandelayo.
Ukucwaninga kwasekuqaleni kule ndawo kubonisa ukuthi abesifazane abanezimpawu ezibaluleke kakhulu zokuqala ngaphambi kokuba babe nemiphumela engaba nesibalo sokuvuvukala esigabeni sokuqhathaniswa uma kuqhathaniswa nabesifazane abanezimpawu ezincane.
I-Genetics
Izinkinga zemizwa ziyaziwa ukuthi ziyasebenza emindenini. Ukwehluleka kwakho ekuthuthukiseni isifo sengqondo esikhathini sakho sokuphila kuzuzwe njengefa kusukela kubazali bakho ngokusebenzisa izakhi zakho zofuzo. Njengezici zomzimba ezifana nokuphakama nombala wamehlo zizuzwa njengefa, ngakho-ke kunezifo ezithile zesifo, kuhlanganise nomdlavuza nokucindezeleka. Kuze kube maduzane, akukho isisekelo sofuzo esinjalo se-PMDD esasungulwe.
Abesifazane abane-PMDD bazwela kakhulu izinguquko ze-hormone ezivamile esigabeni esilandelayo sokujikeleza kokuya esikhathini. Abacwaningi be-NIH bafuna isizathu. Yini abayitholile ukuthi abesifazane abane-PMDD banezinguquko kwesinye sezici zakhi zofuzo ezilawula indlela abasabela ngayo ku-estrogen ne-progesterone. Ngamanye amazwi, kunesisekelo sezakhi zofuzo lwe-hormonal ezibonwa kwabesifazane abane-PMDD.
Lokhu kutholakala kuvumela kakhulu uma une-PMDD. Inikeza ubufakazi obuphathekayo besayensi ukuthi okuthile okuphilayo futhi okungaphezu kokulawula kwakho kubangela ukushintsha kwemizwelo yakho. Iqinisekisa ukuthi i-PMDD akuyona nje ukukhetha kokuziphatha.
Kodwa lezi zithole akuzona indaba yonke. Kodwa impumelelo yalolu cwaningo ikhuthaza ukuqhutshelwa phambili kwezifundo futhi ivula umnyango wokuthola izinketho zokwelapha ezintsha ze-PMDD.
Izwi elivela
Kungenzeka ukuthi kunezici eziningi ezithonya ukuthuthukiswa kwe-PMDD, kodwa into eyodwa eqinisekile ukuthi i-PMDD yinto yangempela hhayi nje into oyenzayo noma ongayifisa. Mhlawumbe kunendlela engaphezu kweyodwa ekhona phakathi kwezinguquko zakho ze-hormone ye-cyclic kanye ne-PMDD.
Ukuthi kungenzeka ukuthi kunezimbangela ezihlukahlukene ze-PMDD ezingasiza ukuchaza ukuthi kungani ezinye zokwelashwa zisebenza kahle kuwe kodwa hhayi kwabanye, futhi ngokufanayo. Kubalulekile ukugcina lokhu engqondweni njengoba wena nodokotela wakho behlola izindlela ezahlukene zokwelashwa ukukusiza ukuba uphile kahle nge-PMDD.
> Imithombo:
> I-Hantsoo L. & Epperson CN (2015) Isifo Sengqondo Esibangelwa Ngaphambi Kokwemvelo: Epidemiology and Treatment. I-Curr Psychiatry Rep., 17 (11) 87. i-doi: 10.1007 / s1920-015-0628-3
> Dubey N, Hoffman JF, Schuebel K, Yuan Q, Martinez PE, Nieman LK, Rubinow DR, Schmidt PJ, Goldman D. I-ESC / E (Z) iyinkimbinkimbi, indlela ehamba phambili yamangqamuzana e-ESC / E (Z) eyahlukana kakhulu ne-ovarian steroids e-Premenstrual Dysphoric I-Disorder, i-Molecular Psychiatry, ngoJanuwari 3, 2016, kufanele: 10.1038 / mp.2016.229.