I-cataplexy kanye nokuhlolwa kwe-Hypocretin kungenza umehluko wezinhlobo ezincane
Ukuhlukumezeka njalo kubonakala ngokulala ngokweqile kwamalanga, kodwa kunezinye izimpawu nemiphumela yokuhlolwa esetshenziselwa ukwehlukanisa izinhlobo ezincane zesimo. Kunezinhlobo ezimbili zokuhlukumeza, kodwa ngabe umehluko phakathi kohlobo lwe-narcolepsy nohlobo lwama-2? Funda ngalezi zingxabano, kufaka phakathi indima ye-cataplexy nokuhlolwa kwamanqanaba e-hypocretin ku-cerebrospinal fluid (CSF).
Izimpawu Zesihluku Sokuhlukunyezwa Kungase Zihlukanise Izinhlobo Ezincane
Zombili izinhlobo zokuhlukumeza izidakamizwa zihlanganisa isidingo esingenakulinganiswa sokulala noma sokuhlwa siphelelwa ukulala. Ngaphandle kokulala, i-narcolepsy akuyona isifo esifanelekile. Kunezinye izimpawu ezihambisanayo, futhi ezinye zazo zingasiza ukwehlukanisa izinhlobo ezincane.
Kunezinhlobo ezimbili zezidakamizwa: uhlobo lwe-1 nohlobo 2. Thayipha 1 lungabandakanya ubukhona besifo se-cataplexy. I-cataplexy ichazwa njengesiqephu esingaphezu kwesisodwa somfushane omfushane, ngokuvamile olinganiselwe wokulahlekelwa komsindo we-muscle nokugcinwa kokuqaphela. Lokhu buthakathaka kungashukunyiswa imizwelo eqinile. Le mizwa ivame ukuhle; isibonelo, i-cataplexy ingase ihlotshaniswe nokuhleka. Ubuthakathaka bungabandakanya ubuso, izingalo noma imilenze. Ezinye izidakamizwa zizoba namajwabu ama-droopy, ukuvulwa komlomo, ukunyakaza kolimi, noma ukushaya ikhanda. Abanye abantu bangakwazi ukuwa phansi ngesikhathi sokuhlasela kwe-cataplexy.
Zombili izinhlobo zokuhlukumezeka zingase zihlanganise nokukhubazeka kokulala nokucutshungulwa kwe-hypnagogic . Ukulala okuhlangene ebusuku kusivame ukuvela kuzo zombili izimo.
Indima Yokuvivinya I-Hypocretin ne-MSLT
Ukuhlolwa okuqondile kungasetshenziselwa ukuhlukanisa phakathi kwalezi zinhlobo ezimbili zokuhlukumezeka. Ukulala ngokweqile kwansuku zonke kunqunywa ngokususelwa kwimiphumela yokuhlolwa kwe-latency latency (MSLT).
Lokhu kuhlolwa kulandela isifundo sokulala okujwayelekile futhi kufaka amathuba amane noma amahlanu aphambanweni atholakalayo ngezikhathi ezimbili. Le ndaba inikezwa ithuba lokulala, futhi abantu abanezinkinga eziphuthumayo bazolala emaminithini angaphansi kuka-8 ngokwesilinganiso. Ngaphezu kwalokho, ukulala kwe-REM kuzokwenzeka kungakapheli imizuzu engu-15 yokulala kuvele okungenani kwamathuba amabili we-nap.
Ngaphezu kwalokho, ukuhlolwa kwamanqanaba e-hypocretin ku-CSF oketshezi njengengxenye yokuqedwa kwe-lumbar kungavezwa. Uma amazinga alinganiselwa ukuthi angaphansi kuka-110 pg / mL, lokhu kuhambisana nokuxilongwa kohlobo lwe-1 lwe-narcolepsy. Uma amazinga avamile (noma angalinganiswanga) futhi i-cataplexy ayitholakali, thayipha i-narcolepsy yesi-2 itholakale uma i-MSLT inhle. Uma izinga le-hypocretin lilinganiswa ukuba lingavamile kamuva, noma uma i-cataplexy iqhubeka, ukuxilongwa kungashintshwa ukuthayipha 1.
Nakuba i-narcolepsy yisimo esingavamile, livela ngokwanele, nehlobo 1 oluthinta abantu abangu-1 ku-5,000. Ukuxilongwa kufanele kwenziwe ngumchwepheshe wokulala okwazi ukusebenzisa ukuhlolwa okufanele futhi kamuva anikeze ukwelashwa okuphumelelayo.
Uma ukhathazekile ukuthi ungase ube nezibonakaliso zezinkinga eziphuthumayo, funa ukuhlolwa okuqhubekayo ngumchwepheshe olele ongakunika ukunakekelwa nokwesekwa okudingayo.
> Umthombo:
> I-American Academy Yokulala Imithi. Ukuhlukaniswa ngamazwe ngamazwe okuphazamiseka kokulala, 3rd ed. Darien, IL: i-American Academy of Sleep Medicine, 2014.