Izifo zesibindi ngenxa yezitatimende kanye nemiphumela yezitatimende eziphathelene nesifo senhliziyo
Ungayiphuza utshwala ne-Lipitor noma iminye imithi yesimanje? Uma ngabe iphakheji libhekisela "ukulinganisela" ukungenisa utshwala, kusho ukuthini lokho? Uyini umphumela wezinhla zesibindi? Kusukela ehlangothini oluphambene, yini esikwaziyo ngomphumela wesimiso esibhedlela sesibindi?
Izinzuzo zezidakamizwa ze-statin njenge-Lipitor (Atorvastatin)
Izitatimende zenze umehluko omkhulu mayelana nesifo senhliziyo.
Bazinzisa imicibisholo ye-coronary engabangela ukuhlaselwa yinhliziyo, imbangela eholela ekufeni e-US ngaphambi komdlavuza. Banciphisa ubukhulu balezi zinhlamvu . Banciphisa ukuvuvukala . Kubonakala sengathi bayasiza nge-clotting engavamile yegazi. Banciphisa ingozi ye-Alzheimer's disease. Zinciphisa ithuba lokuthi uzoba nesifo sengqondo. Bangase bathuthukise nokusinda ngomdlavuza wamaphaphu , imbangela evame kakhulu yokufa komdlavuza emadodeni nakwabesifazane. Ngakho umbuzo mayelana nokuthi kufanele uhlanganise lezi zidakamizwa utshwala kufanele uphendule ngokucophelela.
Isexwayiso se-Alcohol ne-Lipitor (Statins)
Ngokusho kwe- Lipitor esemthethweni i- Lipor (atorvastatin) yokufaka iphakheji-evunywe yi-US Food and Drug Administration (FDA) -Ingqikithi "kufanele isetshenziswe ngokuqapha ezigulini ezidla kakhulu utshwala kanye / noma zibe nomlando wezifo zesibindi." Ngeshwa , ayikho incazelo "esemthethweni" yokuthi yiliphi inani eliningi lokuphuza utshwala lisho.
Ukuze uqonde ukuthi kungani noma yikuphi ukuphuza utshwala kungaba yinkinga nge-Lipitor noma yiziphi iziqu, ake sibheke ukuthi le mithi ingathinta kanjani isibindi, nokuthi utshwala lungakhuphula kanjani lokho.
Umthelela Wezitatimende Esiqhingini
Akuvamile ukuba nezivivinyo zesibindi ezingavamile uma uthatha izitho zomzimba, kodwa kubalulekile ukuqonda okushiwo lokhu.
Kunezindlela ezihlukahlukene zokuchaza ukuthi izitembu zithinta kanjani isibindi, ngakho-ke ake sibheke izinguquko ezivivinyweni zesibindi yedwa (azikho izimpawu,) izifo zesibindi zesifo somzimba (izibonakaliso) ezihlobene nokusetshenziswa kwesimiso, isifo esinamandla sesibindi, kanye nokuthi izitembu zinganciphisa kanjani ngempela ukushona kwabanye abantu asebevele benesifo sesibindi.
Ama-enzyme we-fover nama-Statins afana ne-Lipitor
Izincomo zamanje zukuthi ukuhlolwa kokusebenza kwesibindi kuhlolwe ngaphambi kokuqala i-Lipitor, bese kuthi ngemva kwamasonto angu-12. Ukuqapha kufanele kuqhubeke ngezikhathi ezithile isikhathi somuntu esivela kumuthi. Lokho kusho ukuthi isikhathi eside lapho i-Lipitor isiye khona emakethe, odokotela abaningi abakhulu kakhulu baye baba ukulandela lezi zivivinyo ngokuhamba kwesikhathi.
Ucwaningo luye lwabona ukuthi abanye abantu abasebenzisa i-Lipitor banokuphakama kwe- enzyme ye- aspartate aminotransferase (AST) ne-alanine aminotransferase (ALT.) Ukwanda (kuze kube izikhathi ezijwayelekile ezintathu) kulezi zimiso kubonakala cishe ngamaphesenti amathathu abantu. Lokho esikufundile ngokuhamba kwesikhathi, noma kunjalo, ukuthi isikhathi esiningi lezi ziphakamiso zingezesikhashana futhi azivami neze.
Njengoba ukulinganisela ekutheni udoti ophezulu ungakwandisa ukuhlolwa kokusebenza kwesibindi, ukuhlanganiswa kokuphuza ngokweqile kanye nezitembu kuzokwandisa amathuba okungajwayelekile.
Ukulimala kwesibindi nama-Statins
Ukulimala komuthi kwesibindi-ukulimala okwanele okubangela izimpawu kunokuba nje ukuhlolwa okuvamile okungavamile kwesifo sobindi kuphela-akuvamile kakhulu ngama-statins, ngokungafani nokuphakama kwama-enzyme yesibindi esisodwa esikuqaphele.
Ngokuqinisekile, ukulimala okukhulu kwesibindi kungenzeka. Kukhona okungenani ama-50 amacala okulimala kwesibindi kubantu abathatha izitembu eziye zaholela ekufeni noma isidingo sokufakelwa kwesibindi. Ukubheka lezi zinombolo, kubalulekile ukuthi uqaphele ukuthi ngalesi sikhathi i-Lipitor ibe yisisindo esisodwa esinqunyiwe kakhulu emhlabeni jikelele. (Uma kuqhathaniswa, kucatshangwa ukuthi okungenani abantu abayi-15 000 bafa ngonyaka kusukela ekuguleni kwamathumbu kusuka ku-Advil.) Ukulimala okunzulu kwesibindi kunokwenzeka kumasimini, kodwa lokhu akuvamile.
Uma ukhuluma ngomphumela wokuphuza utshwala esibhedlela sesibindi esihlobene nezitembu, kubalulekile ukuqaphela ukuthi ukulimala kwesibindi esibi akuvamile ngenxa yomphumela wokulimala. Esikhundleni salokho, izidakamizwa ezibangelwa isifo sobindi ngokuvamile ziyisimo se-autoimmune, lapho isidakamizwa senza ezinye izidumbu zabantu ukuba zenze ama-antibodies ahlasela izicubu zabo zesibindi. Lokhu kubhekwa njengokuthi "idiosyncratic" yokusabela, into engaqondakali kahle futhi ayikwazi ukubikezelwa.
I-Side Side ye-Equation - Izitatimende Zingase Zisize Ngezifo Zesibindi
Kungase kube okuqinisekisayo ukuzwa lokho, naphezu kwezincomo zokuqapha ukuhlolwa kwesibindi, kanye nobungozi obungavamile bokulimala kwesibindi, izitembu zingasiza kwabanye abantu abanezifo zesibindi.
Esinye isifundo esibheke abantu abanezifo ezinobuthi obunxilisayo , ukusebenzisa izitho zomzimba kwakunciphisa ingozi yokufa kwesifo sokudakwa ngokweqile. Isiphetho sesifundo se-2017 sasiwukuthi izitembu ezisetshenziselwa abantu abanezifo ezingasiguli zingase zinciphise ukwehluleka kwesibindi kanye nezinkinga zokuhluleka kwesibindi njenge-portal hypertension. Izitatimende zihlolwa njengamanje ngenxa yokwazi kwabo ukunciphisa ukuwohloka kwesifo sesibindi kubantu abanezifo ezingenaso utshwala obunamafutha.
Ngaphezu kwalokho, labo abanesifo sesibindi ngenxa yokutheleleka okungapheli kwesifo se-hepatitis C bangase baphendule kangcono imithi (i-interferon) uma kunikezwa izitembu. (Okuphawula ukuthi utshwala buyabhubhisa isibindi C. )
Kungani Ukuphuza Utshwala Kungabhekana Nezinkinga Ne-Lipitor?
Konke lokhu kusho ukuthi ukuphuza ngokweqile kungabangela inkinga kubantu lapho kuhlangene ne-Lipitor. Ukuhlolwa kohlelo lokusebenza kwesibindi akuyona kuphela impembelelo yecala elikhona. Izinkinga ze-muscle ezinezinhlobo zomzimba azivamile, futhi utshwala lungabangela nomonakalo. Utshwala lungaphinde luphazamise ukusetshenziswa kwemithi eminingi, njengalezo ezingasetshenziswa kanye ne-Lipitor ngesifo senhliziyo. Ukukhathazeka okuyinhloko ngotshwala kubantu abasebenzisa i-Lipitor, noma kunjalo, kungenzeka ukuthi kunezinye izinkinga ezitholakala ngophuzo olulodwa. I-Lipitor nezinye iziqu ezingase zinciphise ingozi yesifo senhliziyo, kodwa utshwala, ngenxa yezimbangela ezinjengezinhliziyo ezidakwa ngokweqile nokunye okuningi, kungase kwande ingozi yakho. Yiqiniso, utshwala lunamakholori amaningi, okunye okwandisa isifo senhliziyo.
Ngezansi ku-Statins no-Alcohol
Abantu abaningi abafuna ngempela ukwazi ukuthi, "Ngingaba nobhiya noma amabili noma ingilazi yewayini ngenkathi ngithatha ama-statins? Kungenzeka ukuthi ukungeza utshwala ku-statins kunomphumela omncane uma kusetshenziswe ngokulinganisela.
Umbuzo wangempela wehlela, "Ingabe unenkinga ngotshwala?" Kulabo abadla kakhulu utshwala (okungaphezu kweziphuzo ezimbili ngosuku ngosuku lomuntu noma ngaphezulu kwesisindo esisodwa ngosuku ngosuku kwabesifazane), cishe kuningi okumele ukhathazeke ngakho kunomphumela esibindi sakho sokuhlanganisa izitembu nokuphuza utshwala.
Ukuphuza ngokulinganisa-Iyini incazelo?
I-US Centers for Disease Control and Prevention (CDC) ichaza ukuphuza ngokulinganisela njengokwesiphuzo esisodwa usuku ngalunye lwabesifazane neziphuzo ezimbili kubantu. Ngokuphathelene newayini, isiphuzo esisodwa singama-ounces amahlanu. Kodwa-ke, abacwaningi abafunda imiphumela emihle yokuphuza utshwala ekuvimbeleni isifo senhliziyo bachaza ukuphuza okulinganiselayo kuze kube yiziphuzo ezimbili ngosuku ngabesifazane futhi kuze kube yiziphuzo ezine ngosuku ngosuku lwabesilisa.
Ukukhathazeka Okuhlobene Nalo Utshwala
Uma unamalungu omndeni noma abangane abaye babonisa ukukhathazeka ngokuphuza kwakho, kubalulekile ukuthi ubuke ngobuqotho ukusetshenziswa kwakho. Uma uphuza, thatha isikhashana bese uzama le mibuzo ukuze ubone ukuthi ungase ube nenkinga yokusebenzisa utshwala.
Khuluma nodokotela wakho mayelana nokusebenzisa kwakho utshwala
Uma uphuza utshwala kufanele uvumele udokotela wakho azi. Abantu abaningi banandaba nokudla kwabo, kepha ukwethembeka nodokotela wakho ekugcineni uzokukhathalela kanye nokusemandleni akho. Udokotela wakho uyazi umlando wakho wezokwelapha kanye nesimanje sezempilo futhi kufanele akwazi ukukwazisa mayelana nokusebenzisa kwakho utshwala.
Thatha isikhathi sokufunda mayelana nokukhethwa kokwelashwa kokudakwa ngokweqile noma ngabe uzikhathalela wena noma umngane noma ilunga lomndeni. Ngokujabulisayo, ngeke kudingeke ukuba uye kude kakhulu ukuzwa izindaba ezinhle kakhulu ezivela kubantu abaye banikezwa ukuqasha okusha kokuphila ngemuva kokushiya.
> Imithombo
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- > Bjornsson, E. I-Hepatotoxicity yamaTatimende namanye ama-Lipid-Ukunciphisa Agents. I-International International . 2017. 37 (2): 173-178.
- > Janicko, M., Drazilova, S., Pella, D., Fedacko, J., noP. Jarcuska. Imiphumela ye-pleiotropic yezimpawu ezitholakala ezifweni zesibindi. I-World Journal ye-Gastroenterology . 2016. 22 (27): 6201-13.
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