I-Technivie (i-ombitasvir + paritaprevir + ritonavir) iyinhlanganisela ye-dose inhlanganisela esetshenziswa ekwelapheni ukutheleleka okungapheli kwe- hepatitis C (HCV) . Lawa ma-agent amathathu ahlanganisa i-Technivie nawo ahlanganiswe emithini emibili ye-pilules ye-HCV, i- Viekira Pak .
I-Technivie yamukelwa ngoJulayi 24, 2015 yi-US Food and Drug Administration (FDA) yokusetshenziswa kubantu abadala kweminyaka engu-18 noma ngaphezulu ne-HCV genotype 4 ukutheleleka (GT4) ngaphandle kwe- cirrhosis .
I-Technivie yiyona yokwelashwa kwe-HCV yokuqala, ephelele-ngomlomo, e-interferon yama-HCV ye-GT4 engavamile ye-HCV, iningi labantu elibhekwa njengelikhuni ukuliphatha.
I-Technivie ibike ukuthi inezinga lokuphulukiswa kweziguli ezingu-100% ezingaphathwa kabi (iziguli "ze-naïve") esivivinyweni seSigaba IIb esenziwa kusukela ngo-Agasti 12, 2012 kuya kuNovemba 19, 2013.
Isilinganiso
Amaphilisi amabili (12.5mg ombitasvir, 75mg paritaprevir, 50mg ritonavir) ethathwa nsuku zonke ngesidlo ngaphandle kwesidingo sokudla okunamafutha aphezulu noma ama-caloric. Amaphilisi we-Technivie anama-pink, ama-oblong nama-film aphethwe, nge-"AV1" embossed ohlangothini olulodwa.
Ukubeka izincomo
I-Technivie inqunywe ngaphezu kwe-12-week course kanye ne-ribavirin (isidakamizwa esasetshenziswa ukuvimbela i-RNA synthesis). Umthamo ophakanyisiwe we-ribavirin usekelwe kwisisindo, kanje:
- Ngaphansi kuka-165 lbs (75kg): 1000mg nsuku zonke, ihlukaniswe futhi iphathwe kabili nsuku zonke ngokudla
- 165 lbs (75kg) nangaphezulu: 1250mg nsuku zonke, ihlukaniswe futhi iphathwe kabili nsuku zonke ngokudla
Inkambo ye-Technivie yezinyanga ezingu-12 ingacatshangelwa ukwelashwa kwe-naïve engakwazi ukubekezelela i-ribavirin.
Imiphumela Ejwayelekile Ejwayelekile
Imiphumela emibi kakhulu ehlobene nokusetshenziswa kwe-Technivie (okwenzeka okungenani iziguli ezingu-7%) yilezi:
- Ukubuthakathaka komzimba
- Ukukhathala
- I-nausea
- Ukungalali
- Rash
Imithi yokwelapha
Izidakamizwa ezilandelayo akufanele zithathwe uma usebenzisa i-Technivie:
- Anticonvulsants: Tegretol, Dilantin, Trileptal, phenobarbital
- I-Antipsychotics: I-Orap
- Imithi ye-antiretroviral: Sustiva
- Imithi ye-statin yokunciphisa i-cholesterol: i-Altoprev, i-Mevacor, i-Zocor
- Imithi yokwelashwa erectile: Revatio
- Izidakamizwa ze-Ergot (ezisetshenziselwa ekwelapheni ikhanda): DHE 45, Ergomar, Ergotrate, Hydergine, Migranal
- I-Estinyl, Apri, Reclipsen, Azurette, Kariva, Yaz, Yasmin, Ocella, Vestura, Beyaz, Safyral, Zovia, Demulen, Demulen 1/35, Kelnor 1/35, Nuva Ring, FaLessa, Lutera, Alesse , Seasonique, Aviane, Ortho Evra, Xulane, Lo Loestrin Fe, Necon 1/35, Minastrin 24 Fe, Loestrin 24 Fe, Ortho Tri-Cyclen, Sprintec, Ortho Tri-Cyclen Lo, Tri-Sprintec, Cryselle, Lo / Ovral, I-Ovral, i-Elinest
- Imithi elwa namagciwane e-Rifampin: I-Mycobutin, i-Rifater, i- Rifamate, i-Rimactane, i- Rifadin, i-Priftin
- Ukuzijabulisa: Ngokweqile, i-Halcion
- Wort St. John's Wort
Ukungafani nokucabangela
I-Technivie ayinconywa iziguli ezinokukhubazeka okulinganayo kwe-hepatic (i-Child-Pugh score B) futhi iphikisana neziguli ezinokukhubazeka okukhulu (i-Child-Pugh score C).
I-Technivie iphikisana nokusetshenziswa kweziguli ezine-hypersensitivity eyaziwayo ku- ritonavir (okungukuthi, ngubani oye wabona uStevens-Johnson Syndrome noma i-necrolysis eyingozi ye-epidermal).
Ngenkathi i-Technivie eyedwa ingavunyelwe ukusetshenziselwa ukukhulelwa, inhlanganisela ye-Technivie ne-ribavirin ingeyona futhi kufanele ingasetshenziselwa abesifazane abakhulelwe noma amadoda abalingani babo abesifazane abakhulelwe. Ngokuphathelene nokuncelisa, kwakungekho izimo zezinhlamvu ezingavamile zokuthuthukiswa komntwana ezifundweni zesilwane; Ukubonisana okwebuchwepheshe kunconywa ukuxoxa ngezinzuzo ezikhona kanye nemiphumela emibi yokuncelisa ngenkathi ku-Technivie.
Umthombo:
I-US Food and Drug Administration (FDA). "I-FDA ivumela i-Technivie yokwelashwa kwesifo esingenasifo sofuba esingapheli 4." I-Silver Spring, e-Maryland; ukushicilelwa okukhishwe ngoJulayi 24, 2015.
Hézode, C .; Asselah, T .; Reddy, R .; et al. "I-Ombitasvir plus paritaprevir plus ritonavir noma ngaphandle kwe-ribavirin ezigulini ezitholakalayo zokwelapha nezifo zokwelapha ezine-genotype 4 ezingenayo igciwane lesandulela ngculaza (PEARL-I): isilingo esivulekile, esivulekile. I-Lancet. Juni 20, 2015; 384 (9986): 2502-2509.