Ukuqonda izingozi nokucutshungulwa kokwelapha
U-Orencia (abatacept) yisidakamizwa se- biologic esivunyelwe ukwelashwa kwesifo samathambo esiyinkimbinkimbi . Ibuye isetshenziselwe ukwelapha i- psoriatic arthritis futhi ihlolisise i-arthritis ye-juvenile idiopathic enamandla.
I-Orencia ayiyona i-blocker ye-TNF njengo- Enbrel (etanercept) noma i- Humira (adalimumab) lapho iphrotheni elivuvukalayo okuthiwa i-tumor necrosis factor (TNF) igxiliwe.
Esikhundleni salokho, u-Orencia usebenza ngokuvimbela izimpawu zamakhemikhali ezibangelwa ukuhlaselwa okuzenzakalelayo.
Ukwelashwa kuyatholakala emafomeni amabili:
- I-Orencia ingahanjiswa eminwebeni engamaminithi angu-30 (intravenous (IV) ukumnika njalo ngemva kwamasonto amane emva kokulayishwa kokuqala kokulinganisa (umthamo wokuqala, umthamo wesibili emavikini amabili, futhi ulinganisa njalo ngemva kwamasonto amane ngemuva kwalokho).
- I-Orencia iyatholakala futhi ekubunjweni okuncane okuvumela abantu ukuba bazibulale ngaphakathi kwethanga, isisu noma ingalo engaphezulu. Ukwelashwa kuvame ukuqala nge-IV yokulandwa kwesilinganiso esilandelwa ukudubula okungezansi ngosuku ngosuku. Lezi zijovo zizenzeke ngeviki ngalinye.
Ngenkathi u-Orencia ekwazi ukunciphisa ukulimala okubambisana nokunciphisa ubuhlungu be-arthritic, kubalulekile ukuqonda ukuthi lo muthi usebenza kanjani, uma kunqunywe, nokuthi yini, uma ikhona, izingozi zihlobene nokusetshenziswa. Nazi amaqiniso amahlanu angasiza:
1. I-Orencia Ijwayele Ukubhaliswa Ngemva Kwezinye Ukwelashwa Kuye Kwahluleka
U-Orencia uvame ukusetshenziselwa abantu abanesifo esiyingqayizivele esibhedlela esiyinkimbinkimbi esingazange basabele kwesinye noma ngaphezulu kwezidakamizwa zokulwa nezifo ( DMARD ) ezifana ne- methotrexate noma ezinye izinto eziphilayo njenge-Enbrel noma i-Humira.
I-abatacept ingasetshenziswa yodwa noma ihlangene nama-DMARD, okwenza kube namandla, kodwa hhayi nezinye izidakamizwa ze-biologic. I-Orencia ingacatshangelwa ukwelashwa kwelayini lokuqala kubantu abane-arthritis esanda kusebenza.
2. U-Orencia Usebenza Ngokunciphisa Umzimba We-Immune System
Imithi ye-biologic esetshenziselwa ukwelapha isifo samathambo ehlose ukuvimbela amasosha omzimba ukuba ahlasele izicubu zawo, ikakhulukazi lezo ezihlangene.
Ukuze wenze lokhu, izidakamizwa zidinga ukuvala izici zokuphendula komzimba. Ngokwenza kanjalo, liphuma emzimbeni evuleleke ekutheleleni okungeke kulwa nalo. Okuvame kakhulu kulawa kufaka izifo zokuphefumula (kuhlanganise ne-pneumonia), i-arthritis ye-septic, izifo zesikhumba kanye nezithambile, nezifo zokungena emanzini.
Kodwa-ke, ucwaningo oluningi lubonise ukuthi i-Orencia ihlotshaniswa nengozi ephansi kakhulu yokutheleleka okungathí sina kanye nokwelashwa uma kuqhathaniswa ne-Enbrel, iRituxan (rituximab), ne-Actemra (tocilizumab).
3. Abantu e-Orencia basengozini eyanda kakhulu yesifo sofuba
Oyinhloko phakathi kokukhathazeka ingozi yesifo sofuba (TB), ngokuyinhloko ukuvuselelwa kwe-TB kubantu abathintekayo ngaphambilini. Ucwaningo lubonisa ukuthi abantu abavelele ku-Orencia banokunyuka okuphindwe kabili engozini yokuvuselelwa okunjalo.
Ngaphambi kokuqala ukwelashwa, abantu kumele bahlolwe i-TB. Abantu abane-TB esebenzayo kumele baphathwe ngempumelelo ngaphambi kokuba noma yisiphi isidakamizwa se-biologic singasetshenziswa.
4. Abantu e-Orencia Kudinga ukugwema imishanguzo ephilayo ngenkathi ekwelashwa
Imithi yokugoma ephikisiwe yilabo abaqukethe amagciwane, ababuthakathaka (uma kuqhathaniswa nemigomo engasebenzi engasebenzisa amagciwane "abulawe").
Ngenxa yokuthi u-Orencia unciphisa amandla omzimba omzimba omuntu, kukhona ithuba lokuthi umgomo wokuphila ungabangela isifo esihlose ukuvimbela.
Ngakho-ke, abantu base-Orencia bayelulekwa ukuba bagweme imigomo ephilayo ngaphambi kokuqala ukwelashwa, ngesikhathi sokwelashwa, kanye nezinyanga ezintathu emva kokuqedwa kokwelashwa. Lokhu kufaka:
- I-flual influenza ( FluMist )
- Imithi yokugoma
- Umuthi wokugoma we-Varicella (inkukhupox)
- Umuthi wokugoma we-measles-mumps-rubella (MMR)
- Umuthi wokugoma we-Rotavirus
- Ukugonywa kwe-yellow fever
- Isiqhwaga
5. U-Orencia Kufanele Asetshenziswe Ngokuqapha Kubantu Abano-COPD
Ezilingo zomtholampilo, abantu abanesifo esingenasifo sokuphefumula ( COPD ) bahlangabezana nesilinganiso esiphezulu se- COPD ngenkathi ku-Orencia, kufaka phakathi ukukhwehlela okuqhubekayo, ukuphefumula nokuphefumula.
Ngenxa yalesi sizathu, u-Orencia kufanele asetshenziswe ngokucophelela kubantu abane-COPD, enesisindo semiphumela emibi. Ngaphezu kwalokho, kufanele kunakekelwe okukhulu ukuqapha abantu abane-COPD uma kwenzeka izimpawu zokuphefumula ziyanda. Esimweni esinjalo, ukwelashwa kungadinga ukumiswa.
> Imithombo:
> De Keyser, F. "Ukukhethwa Kwe-Biologic Therapy for Iziguli ezine-Rheumatoid Arthritis: I-Perspective Infection." I-Curr Rheumatol Isisho . 2011; 7 (1): 77-87. I-DOI: 10.2174 / 157339711794474620.
> Yun, F .; Xie, F .; U-Delzell, E. et al. "Ingozi Eqhathaniswayo Yokutheleleka Kwesibhedlela Ehlanganiswa Nezakhi Zama-Biologic ku-Rheumatoid Arthritis Iziguli Ezibhalisiwe eMedare." I-arthritis ne-Rheumatology . 2015; 68: 56-66. I-DOI: 10.1002 / ubuciko.39399.