Okuthi Siyazi Ngayo
Usalokhu uzwa ukuthi ukugula okungapheliyo (i- ME / CFS ) "ukugula okuyimfihlakalo," kodwa isimo kanye nezinqubo zesifo ziqala ukwakha, ngenxa yemizamo eqhubekayo yabacwaningi. Phakathi neminyaka, ikakhulukazi yakamuva, sifundile inani elikhulu. Olunye lwalolo lwazi lubonisa izindima zokuvuvukala nokuzimela komzimba kungadlala kulokhu kugula.
Ukuqonda ucwaningo, kusiza ukwazi kancane mayelana nezinqubo ngokwabo.
Ukuvuvukala: Okuwusizo & Okulimazayo
Sonke siyazi ukuthi ukuvuvukala kuhileleke ekuguleni okuningi nokulimala, futhi akuvamile ukuthola indlu engenawo okungenani umuthi owodwa wokulwa nokuvuvukala . Siqhwaqisa futhi sikhulisa ukulimala kwethu, ukubenza bangabe besaba kakhulu.
Noma kunjalo, kungase kukumangaze uma ufunda ukuthi ukuvuvukala kuyingxenye impendulo enempilo ezinkingeni zomzimba. Uma isistimu yakho ithola inkinga-kungakhathaliseki ukuthi igciwane elihlasela noma amabhaktheriya, noma izicubu ezonakaliswe ukulimala-kubangela impendulo yokuvuvukala.
Kwenzekani ukuthi lezo zindwangu zegazi zihlanza ukuze zithole igazi elingaphezulu endaweni, futhi amaprotheni engeziwe aqhutshelwa kulowo gazi. Amangqamuzana amhlophe egazi asuka emithanjeni yegazi ibe yinkinga futhi abulale noma ahlanze noma yini engeke ibe khona. Khona-ke izicubu zingaqala ukuphulukisa.
Ngakho uma ushishisa u-shin wakho noma uphazamisa isifuba, ukuvuvukala okuncane kuyinto enhle.
Kusho ukuthi inqubo yokuphulukisa isebenza.
Ngakolunye uhlangothi, uma ukuvuvukala kungapheli ngenxa yokulimala okuqhubekayo noma isimiso somzimba sokuzivikela, khona-ke unenkinga.
Isibonelo somonakalo oqhubekayo kungaba yinto efana nobuhlungu obubuyisela emuva kokulimala okwenyuka ngokungahambi kahle, noma ukulimala okuphindaphindiwe ngenxa yezifo.
Isivikeli somzimba sokuzivikela esingasetshenziselwa ukuzivikela singasho ukuzimela.
Ukuzimela ngokuzenzakalelayo: I-Misfires yeSistimu
Ngokuzenzakalela, umzimba uhlaselwa ngumlilo onobungane. Isivikeli somzimba sokuzivikela senyukile i-haywire futhi manje sikhombisa ingxenye yomzimba wakho njengesisulu sangaphandle. Kanjalo kubangela inqubo yokuvuvukala futhi ithumele emangqamuzaneni akhethekile ukubhubhisa inhloso bese uqala inqubo yokuphulukisa.
Kuphela manje, inqubo yokuphulukisa idala okuningi kwanoma yiluphi uhlobo lomzimba oluyingxenye yesimiso sakho somzimba omzimba asithandi, ngakho inqubo iyaqhubeka ngokungapheli.
Kubalulekile ukuqaphela ukuthi akuwona wonke umsebenzi wokuzivikela omzimba wokuzivikela omzimba okuzenzakalelayo.
I-ME / CFS: Siyini?
Sekuyisikhathi eside abacwaningi bakholelwa ukuthi i-ME / CFS ihilelekile ukuvuvukala okungapheli. Ucwaningo lubonisa izimboni eziningana zokuvuvukala kanye nokuphendula komzimba okuqhubekayo egazini leziguli ze-ME / CFS. Abanye abacwaningi manje bacabanga ukuthi i-ME / CFS ibe yisifo se-neurommune noma se-neuroendocrineimmune.
Noma kunjalo, sisasifunda ngendima ethize yokuvuvukala esimweni. Ucwaningo lwakamuva lubonisa isithombe esikhulayo sokuzimela ngendlela efanayo. Futhi lapho kuhileleka ukuzibandakanya, umbuzo omkhulu uwukuthi: yini okuhloswe kuyo?
Izizathu Ezenzekayo Zokuvuvukala
Iningi lomphakathi wocwaningo lwe-ME / CFS uthatha ukuvuvukala njengoba kunikeziwe. Ngenye igama elithi myalgic encephalitis (ME), eliye lamukelwa abanye abacwaningi, i-encephalitis kusho ukuvuvukala kobuchopho nomgogodla.
Abanye abacwaningi bakhomba ukuthi kungabangela ukuvuvukala okungabandakanyi ukuzimela.
Ucwaningo olwenziwe ngo-2012 oluzama ukuhlukanisa ukukhathala okungapheli, ukukhathala kwesifo somzimba, kanye ne-myalgic encephalitis ngezigaba ezahlukene zathola ukuthi iziguli ze-ME zazinamazinga aphezulu we- cytokines anti-infleukin-1 ne-tumor necrosis factor alpha kanye ne-neopterin, okuyi-indicator umsebenzi we-immune wokuvuvukala.
Muva nje, ucwaningo luye lwabonisa ukuthi izimpawu zokuvuvukala zingahlukanisa ngokunembile isimo esivela ekucindezelekeni noma ekuziphatheni kokugula.
Ucwaningo olunyatheliswa ku- Metabolic Brain Disease luyingxenye eyodwa yomzimba okhulayo ocabangela ukucindezeleka kwe-oxidative ne-nitrosative (i-O & NS) kanye namazinga aphansi e-antioxidant ngendlela engenzeka ngayo ye-ME / CFS, ethi lezi zici zingase zibheke ekuziphatheni kwe-immuno-inflammatory.
(Funda kabanzi mayelana nale ncazelo: Ukucindezeleka okuxubile nePall Protocol .)
Abanye abacwaningi basikisela ukuthi ezinye izifo eziphilayo zingase zibe nomsebenzi wokuzivikela omzimba ongapheli, okwakungabangela ukuvuvukala okungapheli kanye nezinkinga zezinkinga. Omunye wabasolwa abakhulu kule nkinga yi- Epstein-Barr virus , eyabangela i-mononucleosis ("isifo sokubanga.")
Amaphenyo aphenyo olwenziwa ngo-2013 omsebenzi we-retrovirus emgodini ngokusekelwe emcimbini wokuthi, ngokusebenzisa uxhumano lobuchopho-intombazane, ukutheleleka kwegciwane kungabangela ukuvuvukala kobuchopho. Abacwaningi bathola ubufakazi, kepha lokhu kwakuyinkimbinkimbi encane, isifundo sokuqala futhi umsebenzi omningi uhlala kule ndawo.
I-Case for Autoimmunity
Abanye abacwaningi bathole ubufakazi obukhomba ukuthi i-ME / CFS, okungenani ingxenye, isifo esizimele. Kuye kwaphakanyiswa izinhloso ezimbalwa ezihlukene zesistimu yokuzivikela emzimbeni.
Esifundweni sika-2013 esihlolisisa ubuhlobo obunokwenzeka be-O & NS kanye nokuzimela, abacwaningi bathi ukutholakala kwama-cytokines okuvuthayo kanye nezinye izidakamizwa eziningana ezaziwa ezihlobene ne-ME / CFS zingakunqanda ukuba uzimele. Lokho kusho ukuthi umsebenzi we-autoimmune ungabangela umphumela kunesizathu saso. Laba baphandi bacabanga ukuthi ukutheleleka njalo kwegciwane kungase kuholele ezinkambisweni eziningana zokwenza izinto ezingase zenze umonakalo wokuzimela: ukusebenziselwa ukuzamazama nokulinganisa kwamakhemikhali.
Ekulinganiseni kwamangqamuzana, amasosha omzimba avikela i-agent ephathekayo bese eqala ukuyidibanisa neseli elifanayo emzimbeni ngakho-ke uqala ukuhlasela. Eqinisweni, ngoba omabili amangqamuzana abukeka njengodada, isimiso somzimba sokuvikela omzimba sibatshela bobabili amadada, kanti empeleni enye iyigqoko, futhi i-goose ikhona kulowo mvelo.
Ekusebenziseni ukukhanya, umzimba uhlaselwa igciwane, isimiso somzimba samasosha omzimba siphendula ngokusebenzisa amaseli akhethekile, futhi ngenxa yezizathu ezithile, ukuthi ukusebenza ngokuphutha kudala uhlobo oluthile lwamaseli akhethekile-iseli-autoimmune-eqala ukuhlasela izicubu zomzimba.
Esicwaningweni esifanayo, abacwaningi baphinde babhale ezinye izindlela eziningana okungenzeka ukuthi i-ME / CFS ingabangela ukuhamba komzimba, okubandakanya ukungasebenzi kwamamithachondria, okwenza amandla kumaseli akho, kanye nokulimala kwamangqamuzana okubangelwa i-O & NS okwenza isimiso sakho sokuzivikela singakwazi ukuzisiza.
Ucwaningo oluhlukile luka-2013 olubandakanya abacwaningi abaningi abafanayo lwenza ukuthi kungenzeka ukuthi ukuphendula okuzenzakalelayo ku-5-HT, okubizwa nangokuthi i- serotonin . Njenge-hormone neurotransmitter, i-serotonin yenza imisebenzi eminingana ebalulekile kokubili kwamathumbu nobuchopho. Sekuyisikhathi eside ukukholelwa kwe-Serotonin kukholelwa ukuthi kuhileleke kuMe / CFS.
Abacwaningi bathi amaphesenti angaphezu kuka-60 kwabahlanganyeli abane-ME / CFS ahlolwe umsebenzi omuhle wokulwa nomuntu ngokumelene ne-5-HT-ngaphezulu izikhathi ezingu-10 izinga leqembu lokulawula, futhi ama-quadruple isilinganiso salabo abanokukhathala okuhlala isikhathi eside ukuhlangabezana ne-criteria ye-ME / CFS.
Ingabe Izimpendulo Eziningana Zingaba Ngakwesokudla?
Ekugcineni, kungenzeka ukuthi amacala ahlukene we-ME / CFS anezimbangela ezihlukahlukene zokuvuvukala, nokuthi ezinye izimo zizimele ngokuzenzakalela ngenkathi abanye bengekho. Khumbula ukuthi i-ME / CFS ingahluka kakhulu kumuntu oyedwa kuya komunye. Kungenzeka ukuthi ama-subgroups amaningana ahlukahlukene, futhi mhlawumbe nezifo ezehlukene, okwamanje ayiswa emkhatsini owodwa.
Ososayensi basebenzela ukuyihlunga konke. Okwamanje, udinga ukuthola izindlela zokuphatha isimo sakho. Kubalulekile ukuthi usebenze nodokotela wakho ukuze unqume isimo senkathi yakho ethize ye-ME / CFS nokuthi ungcono kangakanani ukuwuphatha.
Imithombo:
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U-Arnett SV, u-Clark IA. I-Journal ye-Affective Disorders. 2012 Dec 10; 141 (2-3): 130-42. Ukhathala okuvuthayo nokuziphatha kokugula - izintambo zokuxilongwa nokuphathwa kwesifo esingapheliyo sokukhathala.
De Meirleir KL, et al. E-Vivo. 2013 Mar-Apr; 27 (2): 177-87. Amaseli e-Plasmacytoid dendritic e-duodenum yabantu abathintekayo okuthiwa ne-myalgic encephalomyelitis ayingqayizivele e-immunoreactive antibodies kumaprotheni omzimba aphethwe yi-retroviral endogenous.
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UMaes M, Ringel K, et al. I-Journal yezifo ezibuhlungu. 2013 Sep 5; 150 (2): 223-30. Ku-myalgic encephalomyelitis / chronic fatigue syndrome, umsebenzi owenziwe ngokuzenzakalela ngokumelene ne-5-HT uhlotshaniswa nezindlela zokuzivivinya umzimba kanye ne-translocation yebhaktheriya.
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Maes M, Twisk FN, Ringel K. Psychotherapy kanye psychosomatics. 2012; 81 (5): 286-95. Ama-biomarker e-inflammatory and cell-mediated immune in myalgic encephalomyelitis / chronic tiredness syndrome kanye nokucindezeleka: Amakaki okuvuvukala aphezulu e-myalgic encephalomyelitis / chronic fatigue syndrome kunokucindezeleka.
UMorris G, no-Anderson G, et al. Imithi ye-BMC. 2013 Mar 8; 11: 64. Ukubuyekezwa okulandayo ngokufana nokungafani phakathi kwe-myalgic encephalomyelitis / chronic tiredness syndrome (ME / CFS) nokuziphatha kokugula.
UMorris G, uBerk M, et al. I-neurobiology ye-molecular. 2013 Sep 26. [I-Epub ngaphambi kokuphrinta] Indima yokumemezela ngokuzimela e-myalgic encephalomyelitis / chronic fatigue syndrome (me / cfs).
UMorris G, Maes M. Izifo zobuchopho zobuchopho. 2012 Jun 21. I-Myalgic Encephalomyelitis / Chronic fatigue syndrome.