I-Aromasin (i-exemestane) iyisidakamizwa esibalulekile iziguli zesifo somdlavuza we-estrogen. Kodwa, njengemithi eminingi yomdlavuza, ifika ilayishwe ngezohwebo. Isiza iziguli eziningi ukuvimbela ukuphindaphinda komdlavuza wesifuba we-estrogen ngokuvimbela ukukhiqizwa kwe-estrogen yomzimba wakho.
Kodwa ukuthatha i-Aromasin kuveza izimpawu ze-menopausal : ukukhanya okushisa okuvamile , ukukhathala, ubuhlungu obuhlangene, ngisho ne-bone thinning.
Ucwaningo lwamuva lushicilelwe e-The Lancet yiqembu labososayensi be-oncology eCanada naseMelika, ebheka imiphumela ye-Aromasin ngempilo yethambo. Baphetha ngokuthi "I-Exemestane iyaphazamisa ukwehla okuhlobene nobudala emithini yezimbiwa zamathambo ngokuphindwe kathathu, ngisho nasesikweni sokudla okwanele kwe-calcium ne-vitamin D."
I-Bone Density Loss
I-Chemotherapy, kanye nemithi yokwelapha yama-hormonal, ingabangela ukulahlekelwa kwamathambo (i-osteopenia) futhi ngezinye izikhathi lapho owesifazane ethatha i-aromatase inhibitor ngemuva kokunakekelwa kwakhe okuyinhloko, amathambo akhe angase aqhubeke elula kuze kube yilapho ehlushwa i-osteoporosis . Lokhu kulahlekelwa kwamathambo kanye namandla kungenziwa ngisho noma kuthatha i-calcium ne- Vitamin D eyanele ukuze ilondoloze impilo yakhe yethambo.
Ucwaningo oluholwa nguDkt. Angela Cheung lwalandela abesifazane abangu-242 ngaphezu kweminyaka emibili ku-Aromasin (i-exemestane). Bonke laba besifazane babenesisindo sokusatshalaliswa kwamathambo esisekelo futhi akukho noyedwa owawuthatha imithi yokwelapha i-osteoporosis.
Laba besifazane babehlukaniswe ngamaqembu amabili-omunye wathatha i-Aromasin kanti abanye bathatha i-placebo. Ngesikhathi bonke abesifazane bebonisa ithambo elincane ekupheleni kweminyaka emibili, iqembu lase-Aromasin laqhubeka libi kakhulu emathambo abo.
Ukulwa nemiphumela emibi
Abaningi besifazane balahlekelwa amanye amathambo njengoba bekhula, ngisho noma bengenayo imithi yokwelashwa.
Amazinga e-Estrogen awela ngesikhathi sokuya esikhathini lapho ama-ovaries akho ayeka ukwenza ama-hormone wesifazane. Ukuthatha i-calcium ne-Vitamin D kungasiza ukubambezeleka kwe-bones thinning, kanye nokuvivinya umzimba. Uma ungakwazi ukubekezelela i-calcium carbonate kahle, zama i-calcium citrate esikhundleni (kulula ukugaya). Udokotela wakho angase ancoma izidakamizwa zokuvimbela ezifana neFosamax noma i-Actonel, ukusiza ukuphatha ukulahleka kwamathambo . Ungase futhi udinga ukuba nesitembu samathambo sonyaka sibheka njengengxenye yokuhlola okwesifazane wakho kahle, ukuqapha impilo yakho yethambo.
> Umthombo:
> Ubuningi be-Bone kanye nesakhiwo emaphoyiseni ase-postmenopausal enempilo aphathwe nge-exemestane ngokuvimbela okuyinhloko umdlavuza webele: indawo engezansi ye-MAP.3 isilingo esilawulwa ngokungahleliwe. UDkt Angela M Cheung MD <, uLieanne Tile MD, Savannah Cardew MD, uSandhya Pruthi MD, et al. I-Lancet Oncology - 7 Febhuwari 2012.