I-Beta i-Amyloid Protein, i-Plaque, ne-Alzheimer's

I-Beta-amyloid amaprotheni kanye ne- plaque - lawa magama amabili ahlobene nobuchopho ashintshe isifo se-Alzheimer. Ufuna ukwazi okuningi? Nazi amaqiniso angu-9 ngawe:

1. Ukwakhiwa kweprotheni ye-beta-amyloid ebuchosheni kubhekwa njengenye yezimpawu zesifo se-Alzheimer's . (Okunye okuphawulekayo okuphawulekayo yizingxenyana ze-neurofibrillary .) Lawa maprotheni ase-beta-amyloid ahlangana ndawonye ukuze enze ama-plaoluble (angakwazi ukuchithwa) ngaphandle kwama-neurons.

1. Ama-proteins e-Beta-amyloid nawo akhiwa ngama- synapses futhi aphazamise ukuxhumana kusuka kwesinye iseli kuya kwesinye ebuchosheni.
2. Ngaphambi kweqoqo le-beta-amyloid likhulu ngokwanele ukuthi libizwa ngokuthi i- plaque , la maprotheni aqala ukwakha ama-oligomers . Ama-oligomers namanje ashubile (akwazi ukuchithwa), amaqembu amancane we-beta-amyloid.
3. Nakuba ama-plaque asekubonwe isikhathi eside njengenye yezimbangela ze-Alzheimer's, abacwaningi basanda kubiza lokhu, behlonza oligomers echazwe ngenhla njengokuthi mhlawumbe ube omunye wezokwelapha eziyinhloko ekuvimbeleni ukuxhumana kusuka esitokisini kuya esitokisini. Esinye isizathu ngemuva kwalokhu ukuthi abanye abantu bane-plaque building-up ebuchosheni, kodwa abanayo isifo se-Alzheimer's .
4. Ukwengeza, olunye ucwaningo luye lwabonisa ukuthi izinguquko zengqondo ziqala ukuqala ngaphambi kwamaprotheni ase-beta-amyloid avela ezinhlakeni ezinkulu zomhlaba.
5. Isayensi ithola amaprotheni angama-beta-amyloid eminyakeni engaphezu kwengu-100 edlule. Baqale babonwa nguDkt. Alois Alzheimer ngo-1906.

1. I-Beta-amyloid iyingxenye yeprotheni ekhudlwana okuthiwa i- amyloid procuror protein .
2. Ukucaphuna okuthakazelisayo: "Ososayensi abaningi bacabanga ukuthi ama-plaques empeleni angase abe umzamo wokuphela kwesigaba sobuchopho ukuze uthole le-beta-amyloid eyingozi kude ne-neurons" (i-Alzheimer's Disease Education and Referral Center).
3. Ucwaningo olwenziwe esikhungweni se-UC Davis Alzheimer's's Centre lwathola ukuthi amasosha omzimba aphendulela ngendlela efanayo ukubeka uphawu njengoba kwenza kuma-bacteria, okwenza ukuvuvukala ebuchosheni obonakaliswe ne-neurons. Ukuvuvukala ebuchosheni buhlanganiswe nesifo se-Alzheimer's.

Imithombo:

_{I-Alzheimer's Association. Imithi yokwelapha i-Alzheimer's Targeting Beta-Amyloid kanye "ne-Amyloid Hypothesis." 2008.}

_{I-Alzheimer's Association. Okuningi mayelana nezindiza.}

_{I-DANA Foundation. Ama-'Oligomers 'angama-Amyloid-Beta angase axhumeke ku-Alzheimer's Dementia. NgoJulayi 12, 2010.}

_{I-National Institute of Aging. Isifo se-Alzheimer's Education and Referral Centre. NgoJanuwari 22, 2015.}

_{I-Stanford Medicine. Ososayensi Ukudalula Indlela I-Beta-Amyloid Engayenza Ngayo I-Alzheimer's. September 2013.}

_{Uhlelo lwezempilo lwe-UC Davis. I-Alzheimer's-causing Amyloid and Bacteria Trigger Impendulo efanayo ye-Immune.}