Ukuthatha imidlalo nokuyisebenzisa kwimigomo yempilo yangempela nemisebenzi, into eyaziwa ngokuthi "ukuhlanganiswa," iyaqhubeka phambili ngesivinini se-warp ngenxa yezwe lethu le-digital-mobile. Ukumaketha kuye kwafaka phakathi ezindaweni ezihlukahlukene ezihlanganisa imidlalo yokuzithuthukisa, imidlalo yokukhuthaza izinguquko ezinhle zokuphila, ngisho nemidlalo yokwandisa isisusa sokuqedela izinhloso zomsebenzi.
U-Genentech, inkampani ehamba phambili ye-biopharmaceutical, manje udlala isayensi ngemuva kokwelapha umdlavuza-futhi abodwa. Kodwa i-gamification ihambisana kanjani neziguli zomdlavuza? Yebo, ngesiguli esinomdlavuza, ukuzama ukuhlela ikusasa kungaba yinto emangalisayo. I-jargon yesayensi, imigomo yezobuchwepheshe, izifinyezo, kanye nama-acronym akusizi izinto. Isikhathi sokusinda, isibonelo, singalinganiswa ngezindlela ezihluke kakhulu, ngakho-ke futhi impendulo yesiguli yomdlavuza ingayithola ekwelapheni. Yilapho i-Mission: i-MRD ingena.
Isithunywa: MRD
I-Genentech idale umdlalo omusha wesibili weselula wesi-60, I-Mission: i-MRD, ukufundisa abantu mayelana nesifo esincane sokusala (i-MRD) - indlela yokulinganisa impendulo yomuntu emithini yokwelapha enikeziwe noma irejista.
Izinhlobo eziningi zesifo somdlavuza wegazi- kuhlanganise ne-lymphocytic leukemia (CLL) engavamile, i-leukemia yabantu abadala abavamile-yizinhlobo ezidinga ukulawulwa nemithi yokwelapha elwa nomdlavuza ngokuhamba kwesikhathi, okusho ukuthi ungalokothi uqede ngempela wonke umlenze womdlavuza wokugcina.
Lokhu kuholela ekuphindeni, ngakho odokotela bazama ukuqaphela kakhulu uma kuziwa egameni elithi "ukwelashwa."
In Mission: MRD, umsebenzisi uhamba ngegazi, ebulala amaningi amangqamuzana omdlavuza ngangokunokwenzeka ngomgomo wokufinyelela i-MRD-ukungaboni kahle. Kubalulekile ukuqaphela ukuthi lo mdlalo ngokuyinhloko ukuzijabulisa futhi akuhlosiwe ukuba unempilo noma ngokwesayensi ngokunembile, kodwa kunokuqaphela isimo se-MRD.
I-MRD-Ukungabi nandaba
Uma othile onesi-CLL efinyelela ku-MRD-ukungabi nandaba, kusho ukuthi ayikho amangqamuzana omdlavuza angatholakala kumasampula we-marrow we-bone usebenzisa ukuhlolwa okuqondile. Manje, ngenxa yomdlavuza onjenge-CLL, kusengenzeka ukuthi lesi sifo sibuyele emuva, ngisho nangemva kokuba isiguli sesifinyelele ukungaboni kahle kwe-MRD; Nokho, ukufeza i-MRD-ukungaboni kahle kuyabonakala kuyinto enhle futhi yingakho:
- Kunezindlela eziningi zokukala umthwalo wesifo emdlalweni. Isimo se-MRD-negative ku-CLL senzeke ngezobuchwepheshe ezintsha, ezibucayi kakhulu.
- Uma umuntu onenkinga ye-CLL efika ku-MRD-ukungabi nandaba, kusho ukuthi akukho mdlavuza ongatholakala emasampula egazi noma amathambo omongo usebenzisa ukuhlolwa okuqondile okusebenzisa izindlela ezibucayi kunendlela endala yokubala amaseli ngamaphesenti angu-100 ngaphansi kwe-microscope.
- I-MRD-ukungaboni kahle kungase kuhlotshaniswe nemiphumela engcono. Umsebenzi omningi udinga ukwenziwa kodwa ubufakazi obusayo bubonisa ukuthi i-MRD-ukungabi nandaba ngemva kokunye ukwelashwa kungase kubikezele ukuxolelwa okude futhi mhlawumbe isikhathi esiningi sokusinda kaningi kwegazi lomdlavuza.
Imidlalo Yomdlavuza Yomuso
Eminye imidlalo ihlelwe futhi izithombe nezincazelo ezihlukahlukene ziyatholakala kwiwebhusayithi ye- Genentech ukukusiza uqonde umjikelezo wokuvimbela umdlavuza - inqubo eholela ekuthuthukiseni ukuvikelwa komzimba ngamagciwane omdlavuza.
Imithombo:
Smolej L, Šimkovič M. Indlela ewusizo yokuphathwa kwegazi elingelapheki i-lymphocytic leukemia. I-Archives yeSayensi Yezokwelapha: AMS. 2016; 12 (2): 448-456.
UHallek M, uCheson BD, uCatovsky D, et al. Imihlahlandlela yokuxilongwa nokuphathwa kwegazi elingelapheki i-lymphocytic leukemia: umbiko ovela ku-International Workshop on Chronic Lymphocytic Leukemia ukuvuselela umhlahlandlela weNational Cancer Institute-Working Group 1996. Igazi . 2008; 111: 5446-56.
UHallek M, uFischer K, uFingerle-Rowson G, et al. Ukwengezwa kwe-rituximab ku-fludarabine ne-cyclophosphamide kuziguli ezine-leukemia ezingelapheki: i-randomized, evulekile, isilingo sesi-3. I-Lancet. 2010; 376: 1164-74.
I-Bottcher S, uRitgen M, uFischer K, et al. I-quantification yesifo esinqunyiwe encane iyisimo sokuzimela esizimele sokungaqhubeki kokuqhubekayo nokungasondeli okuphelele kulesifo esingelapheki se-lymphocytic leukemia: ukuhlaziywa okunomthelela emanzini okuhlolwa okungahleliwe kwe-GCLLSG CLL8. J Clin Oncol . 2012; 30: 980-8.