Ukwelashwa kwangaphambi kokuhlinzwa kunciphisa ukuphindaphindiwe kwendawo kodwa akude kakhulu
Ucwaningo olwanyatheliswa eNew England Journal of Medicine lwathola ukuthi iziguli ezinezigaba 2 noma isigaba somdlavuza we- stage 3 ezithola isifo samakhemikhali kanye nemisebe ngaphambi kokuhlinzwa kwakungekho amathuba okuphindaphinda kuneziguli ezithola i-chemo nemisebe ngemva kokuhlinzwa.
Abacwaningi bacwaninga iziguli ezingaphezu kuka-800 ngesigaba sesi-2 nesigaba somdlavuza wesi-3.
Cishe uhhafu wathola i-chemo kanye nemisebe ye-radiation (chemoradiation) ngaphambi kokuhlinzwa futhi omunye uhhafu wathola i-chemoradiation ngemuva kokuhlinzwa. Ukulandela isiguli emva kweminyaka emine ukwelashwa kwathola inzuzo ecacile yeqembu langaphambi kokuhlinzwa.
Ucwaningo Lukhombisa Ukuphindaphinda Kwangaphakathi Kwesifo Se-Rectal Cancer nge-Pre-Operative Chemoradiation
Ngokucacile, iziguli ezingu-6% ezitholakale ngamakhemikhali ngaphambi kokuhlinza zaphindaphindiwe, ngokubhekene neziguli ezingu-13% ezitholakalayo ngemuva kokuhlinzwa. Iziguli eziseqenjini lokuqala langaphambi kokuhlinza laphinde labhekana nemiphumela emibi kakhulu emithini yokwelashwa, njengokuhuda nokunciphisa kwesilonda lapho ibuye ixhunyiwe emva kokuba isisu susiwe. Ivumela izinga elikhulayo lokulondolozwa kwe-sphincter kuziguli ezinezinambuzane eziphansi. Abacwaningi futhi abazange babone ukukhula kwe-tumor ekwandiseni ukuhlinzwa kwamasonto angu-12 oku-pre-treatment kanye nokubuyiselwa kulelo qembu.
Ukwelashwa okunikezwayo kwakungama-radiotherapy izikhathi ezinhlanu ngeviki inani eliphelele lama-5040 cGy.
I-chemotherapy eyanikezwa yi-fluorouracil phakathi namasonto okuqala namahlanu we-radiotherapy. Kuleli qembu lokuqala lokulashwa, ukuhlinzekwa kwahlelwe amasonto ayisithupha emva kokuqedwa kokwelashwa. Womabili amaqembu athole ezinye izijikelezo ezine ze-fluorouracil ngemuva kokuhlinzwa.
Akukho Ukuhluka Kokuphindaphindiwe Kokuphindaphindiwe Kwamazinga kanye Nokusinda Okuphelele Nokusebenza Kokusebenza Kokuqala
Nakuba isikhathi sokwelapha senza umehluko wemiphumela emibi kanye namanani okuphindaphinda wendawo, kwakungabonakali okwenza umehluko uma kufike ekusindeni jikelele noma ithuba lokuthi umdlavuza uzosakazeka engxenyeni ehlukile yomzimba.Izinga elide eliphindaphindiwe kwakufana nalawo maqembu amabili.
Luhle kangakanani lolu cwaningo kuwe?
Uma usuzokwamukela ukuhlinzekwa kwesigaba sesi-2 noma isigaba sesi-3 somdlavuza we-rectal, ungase ufune ukukhuluma nodokotela wakho mayelana nokuthola i-chemotherapy kanye nemisebe ngaphambi kokuhlinzwa kunokuba ngemuva. Ngokusho kwalolu cwaningo, ukwenza kanjalo kunganciphisa amathuba akho okuphindaphinda kwendawo futhi uthuthukise izinga lakho lokuphila ngesikhathi nangemva kokwelashwa.
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Imithombo
Imiphumela Yokuhlolwa Kwamtholampilo: Ukwelashwa Ngaphambi Kokuhlinzwa Kusiza Ukuvimbela Ukwehla Kwendawo Yomdlavuza Osezingeni Lendawo. I-National Cancer Institute. 26 Aug. 2006 [http://www.cancer.gov/clinicaltrials/results/pre-op-rectal1005/print?page=&keyword=].
Sauer, R. noBerker, H. "I-Preoperative Versus Postoperative Chemoradiotherapy ye-Cancer Rectal." I-New England Journal of Medicine 351.17 (Okthoba 2004): 1731-1740. 26 Aug. 2006 [http://content.nejm.org/cgi/content/abstract/351/17/1731].