Ukuhlukaniswa
I-Evotaz (atazanavir + cobicistat) iyinani elinqunyiwe elihlanganiswa nomuthi we- antiretroviral esetshenziswa ekwelapheni i- HIV . Izingxenye ezimbili zomuthi zidayiswa njengeReyataz (atazanavir) noTybost (cobicistat) .
Ukuhlanganiswa kwe-single-pilules kuvumela ukulula okulula, kanye-kwansuku zonke, kanye ne-cobicistat component ngokuphumelelayo "ukukhuthaza" nokugcina ukuhlushwa kwe-plasma ye-atazanavir emzimbeni.
U-Evotaz wamukelwa yi-US Food and Drug Administration (FDA) ngoJanuwari 2015 kubo bonke abagulayo abasha nabahlangenwe nakho abane-HIV-1.
Ifomu
Ithebhulethi ene-oblong egcwele ifilimu, enama-300mg atazanavir no-150mg cobicistat, i-pink inemibala futhi ifakwe izinombolo "3641" ngakolunye uhlangothi.
Isilinganiso
Ithebhulethi eyodwa ithathwa nsuku zonke ngokudla. I-Evotaz ayikwazi ukusetshenziselwa yedwa kodwa kufanele ithathwe ngokuhambisana nomuthi owodwa noma ngaphezulu ohambisana nezidambisigciwane.
Imiyalo
Ngaphambi kokuqala, iziguli kufanele zihlolwe ukuze zihlolwe imvume yabo yokuqalwa kwama-creatinine njengoba i-Evotaz ingase ibangele ukusebenza kwe-renal (izinso), ikakhulukazi ezigulini ezinezifo ezingasebenzi ezingaziwa noma ezingaziwa. Uma uqondiswa nge- Viread (i-tenofovir ) -isidakamizwa esingabangela ukukhubazeka kwamaphutha kwezinye-kunconywa ukuthi iziguli zivivinywe imvume yokucatshangelwa kwe-creatinine, i-glucose yomchamo, kanye ne-protein yomchamo.
Kunconywa ukuthi iziguli ezinolwazi lwezokwelashwa, ikakhulukazi lezo ezivezwe nge-HIV protease inhibitors , zihlinzekwa ukuhlolwa kokuphikiswa kwezakhi zofuzo ngaphambi kokuba kubekwe u-Evotaz.
Uma ukuhlolwa kwe-genotypic kungatholakali, u-Evotaz kufanele agwenywe kunoma ubani ovezwe ngaphambilini kwi-HIV protease inhibitors.
Imiphumela Ejwayelekile Ejwayelekile
Esifundweni sesifundo se-Phase III somuntu, kunezibalo eziningana zomuthi wezokwelapha eziye zabonakala uma usebenzisa u-Evotaz. Izenzakalo ezivame kakhulu, ezibikwe ngo-2% noma ngaphansi kweziguli ezisanda kuphulukiswa, zazi:
- I-jaundice (i-yellowing yesikhumba namehlo)
- I-icterus ye-Ocular (ukuphuka kwamehlo)
- Rash
- I-nausea
Imiphumela emibi engavamile ihlanganisa ukukhathala, ikhanda, ukulala, ukuhlanza kanye nobuhlungu obuphezulu besisu. Amatshe aso aphinde ahlonishwa kwezinye iziguli lapho uVevotz ephathwa nge-Viread (tenofovir), nakuba amacala ayebhekwa njengobumnene futhi awazange akhiphe ukuyeka ukukhipha ukwelashwa.
Ukuphikisana kwezidakamizwa
I-Evotaz akufanele ithathwe ngezidakamizwa ezilandelayo noma izithako ze-herbal:
- Imithi elwa ne-anginal: Ranexa
- Imithi Anti-arrhythmic: Multaq
- Imithi ye-anti-cholesterol: Mevacor, Zocor
- Imithi yokulwa ne-gout: i-Uroxatral
- Imithi yokwelapha ngokweqile: Revatio
- Imithi ye-Antipsychotic: Latuda, Orap
- Imithi yokwelapha: I-Camptosar, i-Campto
- I-Ergot equkethe izidakamizwa zokulwa ne-migraine: DHE 45, Ergotrate, Hydergine, Migranal
- Imithi elwa namagciwane e-Rifampin: I-Mycobutin, i-Rifater, i- Rifamate, i-Rimactane, i- Rifadin, i-Priftin
- Ukuzijabulisa: Dormicum, Halcion, Hypam, Hyponvel, Trilam, Versed
- Wort St. John's Wort
Ukusebenzisana kwezidakamizwa ze-antiretroviral
Ukusetshenziswa kukaTybost ngokulandela izidakamizwa ze-antiretroviral kungaholela ekulahlekelweni komphumela wokwelashwa kwesidakamizwa esihambisana nalokhu noma ukwanda kwemiphumela emibi:
- I-Crixivan (indinavir) akufanele iqondiswe nge-Evotaz.
- Intelence (etravirine) akufanele iqondiswe nge-Evotaz.
- USustiva (efavirenz) akufanele aqondiswe nge-Evotaz.
- I-Viramune (nevirapine) akufanele iqondiswe nge-Evotaz.
- Umthamo we-Selzentry (maraviroc) kufanele ulungiselelwe ku-150mg kabili ngosuku uma ulawulwa u-Evotaz.
Okunye ukusebenzisana noma ukucabangela
- Yazisa udokotela wakho nganoma yikuphi isimo esaziwayo noma esicatshangelwayo (izinso) ongaba nayo ngaphambi kokuqala u-Evotaz.
- Yazisa udokotela wakho nganoma yikuphi isimo esaziwayo noma esicatshangelwa ukuthi u-hepatic (isibindi) ongase ube nayo ngaphambi kokuqala u-Evotaz, kuhlanganise nesifo se-hepatitis A, i- hepatitis B noma i- hepatitis C.
- Ama-antacids ane-aluminium noma i-magnesium hydroxide angavimbela i-Evotaz ukuba ingene kahle. Uma usebenzisa i-anti-the-counter antiacid (isib. I-Rolaids, i-Tums, i-Milk ye-Magnesia), kunconywa ukuthi kuthathwe amahora amabili ngaphambi noma ngemuva kwe-dose Evotaz.
- Ama-H2-abaphikisi abavame ukuvimbela isisu esiswini (isb., I-Tagamet, i-Pepcid, i-Axid, i-Zantac) nayo ingavimbela ukungena kwe-Evotaz. Kunconywa ukuthi bathathwe nge-Evotaz noma, ngokunye, amahora angu-10 ngaphambi noma ngemuva kwe-dose Evotaz.
- I-Proton pump inhibitors (isb., I-Losec, i-Prilosec, i-Prevacid, i-Nexium, i-Pariet) ingavimbela ukuxhunywa kwe-Evotaz. Kunconywa ukuthi kuthathwe amahora angu-12 ngaphambi noma ngemuva kwezinga likaVotaz.
- Imithi yokuphuza erectile (i-Viagra, i-Levitra, i-Cialis) kufanele isetshenziswe ngokuqapha njengoba i-Evotaz ingakhuphula izinga lemiphumela emibi, kuhlanganise nokuphazanyiswa okubukwayo, i-hypotension, kanye nokuphambana (okubuhlungu, okunamandla). Kunconywa ukuthi i-Viagra isilinganiso sincishiswe singabi ngaphezu kuka-25mg emahoreni angu-48; Umthamo we-Levitra wehlisiwe ungabi ngaphezu kuka 2.5mg emahoreni angu-72; futhi isisindo se-Cialis sincishisiwe singabi ngaphezu kuka-10mg emahoreni angu-72.
- Ngesikhathi sokukhulelwa, u-Evotaz akufanele abekwe ngesikhathi sesigamu sesibili noma sesithathu, uma isiguli esithwele sithatha i-H2-acceptor antagonist noma i-Viread (i-tenofovir) njengoba kungase kube nengozi ye-kernicterus (isimo esingavamile esenzeka ezinganeni ezisanda kuzalwa i-jaundice eqinile).
Imithombo:
I-Bristol-Myers Squibb. "I-Evotaz (Atazanvir + cobicistat) - ULWAZI LOKUPHILA OKUQHELEKILE." ENew York, eNew York; ifinyelelwe ngoFebhuwari 3, 2015.