Ukuhlukaniswa:
I-Tybost (cobicistat) yisidakamizwa esichazwa njenge-CYP3A inhibitor esetshenziselwa ukwelashwa kwe- HIV . U-Tybost usebenza "ngokukhulisa" ukuhlushwa kwe-plasma yemithi elwa nezidambisigciwane, i-Vitekta (elvitegravir), i- Reyataz (atazanavir) ne- Prezista (i-darunavir) , uma isetshenziselwa ukwelashwa kwama-antiretroviral (ipati) .
I-Tybost iyingxenye yezinhlanganisela ezintathu ezilinganiselwe izidakamizwa, i- Stribild (elvitegravir + cobicistat + tenofovir + emtricitabine) , u- Evotaz (atanazavir + cobicistat) no- Prezcobix (i-darunavir + cobicistat) ,
U-Tybost wamukelwa yi-US Food and Drug Administration (FDA) ngoSepthemba 2014 kubo bonke abagulayo abadala nabasanda kutholwa abane-HIV-1.
Ifomu:
I-tablet ye-150mg ehlanganiswe ngefilimu, i-orange ekhanyayo embala futhi ibhalwe ngezinhlamvu "GSI" ngakolunye uhlangothi.
Isilinganiso:
Ithebulethi eyodwa ka-150mg ethathwa nsuku zonke ngokudla ngesikhathi esisodwa njengoReyataz noma i-Prezista. Ukwelashwa kufanele kufake enye noma ngaphezulu, ehambisana nemithi noma izidambisigciwane.
Imiyalo:
Ngaphambi kokuqala, iziguli kufanele zihlolwe ukuze zihlolwe imvume yokuqalwa kwe-creatinine njengoba u-Tybost angase akwazi ukulimaza umsebenzi wezinso (izinso), kaningi ezigulini ezinezifo ezingasebenzi ezingaziwa noma ezingaziwa. Uma uqondiswa nge- Viread (i-tenofovir) -isidakamizwa futhi saziwa ngokubangela ukukhubazeka komonakalo kwezinye-kunconywa ukuthi iziguli zihlolwe ukuvunyelwa kwe-creinine esilinganiselwe, i-urine glucose kanye namaprotheni omchamo.
Imiphumela emibi evamile:
Esifundweni sesifundo se-Phase III somuntu, kunezibalo eziningana zezidakamizwa ezingase zibonwe uma usebenzisa i-Tybost.
Izenzakalo ezivame kakhulu, ezibikwe ku-2% noma ngaphansi kweziguli, zaziyizi:
- I-jaundice (i-yellowing yesikhumba namehlo)
- I-icterus ye-Ocular (ukuphuka kwamehlo)
- I-nausea
- Uhudo
Imiphumela emibi engavamile ihlanganisa ukukhathala, ikhanda, ukulala, ukuhlanza kanye nobuhlungu obuphezulu besisu. Amatshe asezinso nawo ahlonishwe kwezinye iziguli lapho u-Tybost eqondiswa khona noReyataz noViread, nakuba amacala ayebhekwa njengobumnene futhi awazange akhiphe ukwelashwa.
Ukuphikisana kwezidakamizwa:
U-Tybost akufanele athathwe ngezidakamizwa ezilandelayo noma izithako ze-herbal:
- Imithi Anti-arrhythmic: Multaq
- Imithi ye-anti-cholesterol: Mevacor, Zocor
- Imithi yokulwa ne-gout: Uroxatral
- Imithi yokwelapha ngokweqile: Revatio
- Imithi yokulwa ne-psychotic: I-Orap
- Imithi yokwelapha: I-Camptosar, i-Campto (lapho iqondiswa noReyataz)
- Ama-derivatives anama-anti-migraine ane-Ergot: DHE 45, Ergotrate, Hydergine, Migrana
- Imithi elwa namagciwane e-Rifampin: I-Mycobutin, i-Rifater, i- Rifamate, i-Rimactane, i- Rifadin, i-Priftin
- Ukuzijabulisa: Dormicum, Halcion, Hypam, Hyponvel, Trilam, Versed
- Wort St. John's Wort
Ukusebenzisana kwezidambisigciwane:
Ukusetshenziswa kukaTybost ngokulandela izidakamizwa ze-antiretroviral kungaholela ekulahlekelweni komphumela wokwelashwa kwesidakamizwa esihambisana nalokhu noma ukwanda kwemiphumela emibi:
- I-Crixivan (indinavir) akufanele iqondiswe nge-Tybost noReyataz.
- Intelence (etravirine) akufanele iqondiswe nge-Tybost.
- U-Sustiva (efavirenz) akufanele aqondiswe ngu-Tybost no-Prezista.
- I-Viramune (i-nevirapine) akufanele iqondiswe nge-Tybost ne-Prezista.
- Umthamo we-Selzentry (maraviroc) kufanele ulungiselelwe ku-150mg kabili ngosuku uma ulawulwa yi-Tybost.
Okunye ukusebenzisana noma ukucabangela:
- Yazisa udokotela wakho nganoma yisiphi isimo esaziwa noma esasolwa ukuthi unesifo ngaphambi kokuba uqale u-Tybost.
- I-Antacids ene-aluminium noma i-magnesium hydroxide ingavimbela u-Tybost / Reyataz ukuba angene kahle. Uma usebenzisa i-anti-counter antacid (isib. I-Rolaids, i-Tums, i-Milk ye-Magnesia), kunconywa ukuthi kuthathwe amahora amabili ngaphambi noma ngemuva kwesilinganiso se-Tybost / Reyataz.
- Ama-H 2- abaphikisi abavame ukuvimbela isisu esiswini (isb., I-Tagamet, i-Pepcid, i-Axid, i-Zantac) nayo ingavimbela ukungena kwe-Tybost / Reyataz. Kunconywa ukuba bathathwe noTybost / Reyataz noma, ngokunye, ihora eli-10 ngaphambi noma ngemuva kwesilinganiso sikaTybost / Reyataz.
- I-Proton pump inhibitors (isb., I-Losec, i-Prilosec, i-Prevacid, i-Nexium, i-Pariet) ingavimbela ukuxhunwa kwe-Tybost / Reyataz. Kunconywa ukuthi kuthathwe amahora angu-12 ngaphambi noma ngemuva kwesilinganiso sikaTybost / Reyataz.
- Imithi yokwelashwa erectile (i-Viagra, i-Levitra, i-Cialis) kufanele isetshenziswe ngokuqapha njengoba u-Tybost angakhuphula izinga lemiphumela emibi, kuhlanganise nokuphazanyiswa okubukwayo, ukuxilonga, nokuzibamba (ukuhlushwa okubuhlungu, okuqhubekayo). Kunconywa ukuthi i-Viagra isilinganiso sincishiswe singabi ngaphezu kuka-25mg emahoreni angu-48; Umthamo we-Levitra wehlisiwe ungabi ngaphezu kuka 2.5mg emahoreni angu-72; futhi isisindo se-Cialis sincishisiwe singabi ngaphezu kuka-10mg emahoreni angu-72.
Imithombo:
I-Sciences yaseGileyadi. "U-Tybost (cobicistat) - ULWAZI LOKUPHILA OKUQHELEKILE." Foster City, California; ifinyelelwe ngoFebhuwari 3, 2015.