Ungakwazi Yini Ukushayela I-Cancer Ukufa?
Ingabe ushukela ubangela umdlavuza? Uma usuvele unomdlavuza, ushukela ungakwenza yini ukuba ukhule ngokushesha? Umbuzo olayishiwe, kodwa impendulo ayilula.
Wonke amaseli akho adinga i-glucose (ushukela wegazi) wamandla. Amangqamuzana anempilo alandela umjikelezo wokuphila, ukuhlukana nokufa. Njengamaqabunga esihlahleni, amangqamuzana endala ayafa futhi athathe inani elilinganayo lamaseli anempilo.
I-Cancer iqala uma amangqamuzana endala enqaba ukufa kodwa aqhubeke ekhula, ehlukanisa futhi ewakhiwe endaweni eyodwa-ekwakheni isisu .
Ingabe Umdlavuza Ushukela?
Umqondo wokuthi amangqamuzana omdlavuza aphumelele ngoshukela kuye kwaba cishe okungenani kusukela ngo-1924 kwanyatheliswa iphepha likaDkt. Otto Warburg, ku-Metabolism of Tumors. IWarburg yayiyi-biologist ye-Nobel-Prize-Prize-winning biologist eyayinomqondo wokuthi ukukhula komdlavuza kwabangelwa lapho amangqamuzana omdlavuza eguqula i-glucose ibe amandla ngaphandle kokusebenzisa i-oxygen. Lokhu kwakusho okuthakazelisayo, okuyingxenye ngoba siyazi ukuthi amaseli aphilile enza amandla ngokuguqula i-pyruvate ne-oxygen. I-pyruvate iboshelwe ngaphakathi kwe-mitochondria yeselula enempilo. Njengoba amangqamuzana omdlavuza akhiqizi i-pyruvate, iWarburg yacabanga ukuthi umdlavuza kufanele uthathwe njengokungasebenzi komzimba.
Kodwa akunjalo ukuthi umdlavuza usebenza kanjani. I-Cancer ibangelwa ukushintshashintsha kwezakhi zofuzo , noma ukushintshashintsha kwefa, noma lokho okutholakala ngokuhamba kwesikhathi ngokusebenzisa ukutholakala kwama-carcinogens noma ngenxa yesimiso sokujwayelekile samangqamuzana.
Nakuba amangqamuzana anempilo namangqamuzana omdlavuza aguqula ukudla kwawo emandleni ngezindlela ezehlukene, lowo umehluko umphumela , hhayi imbangela, yomdlavuza. (Funda ngokungafani phakathi kwamangqamuzana omdlavuza namaseli avamile .)
Ushukela ne-Hyperglycemia
Naphezu kokuthola iphutha emshukela kanye nomdlavuza ezindabeni zesikhathi esidlule, kubonakala sengathi kukhona ukuxhumana phakathi kwamazinga okushukela ngokweqile nomdlavuza.
Kuyaziwa kahle ukuthi abantu abane-type II yesifo sikashukela banomngcipheko owandayo wezinhlobo eziningana zomdlavuza. Kuye kwaboniswa ukuthi izinga eliphezulu likashukela egazini lingabangela ekwakhiweni kwamangqamuzana omdlavuza (oncogenesis), ukumelana nokufa kweseli kumangqamuzana omdlavuza (ukumelana ne-apoptosis) kanye nama-tumor aphikisana ne-chemotherapy. Kungakhathaliseki ukuthi lokhu kukukhathazeka "ngokujwayelekile" ushukela wegazi ophakeme, njengokuthi i-dessert splurge kuphela kuphela kulabo abane-insulin ukumelana nokuphakama kweshukela egazini akuqinisekisi ngokuphelele.
Ushukela Namaprotheni Gcina Amaseli E-Cancer Aphila
Kuye kwathiwa ukuthi amangqamuzana omdlavuza awafi-awafi ngendlela ehlelekile njengamaseli aphilile enza. Ososayensi baye bafunda le mphumela futhi kungenzeka ukuthi bathole ukuthi yiziphi amangqamuzana amathumba ukuze agweme ukufa kweseli. Ekucwaningweni kwelabhutri eDuke University, amangqamuzana omdlavuza avela ukusebenzisa inhlanganisela ushukela namaprotheni athile ukuze aqhubeke ekhula uma kufanele afe. Lezi zingqamuzana zomdlavuza zibonakala zisetshenziselwa ushukela ngezinga eliphezulu, ukuze ungayinaki imiyalelo yeselula ukuze ufe.
Ukuthuthukisa izidakamizwa ezintsha ze-Cancer
E-Johns Hopkins University, iqembu labacwaningi babheka izindlela zokukhohlisa amangqamuzana omdlavuza ekukhuleni kancane kancane bese ekugcineni bezibulala.
Bafunda i- glycosylation engavamile- ukuthi amangqamuzana omdlavuza abeka kanjani ushukela namaprotheni ndawonye ukuze bazinakekele. Lapho la maseli enikezwa i- n- butyrate (usawoti) nge-carbohydrate (ushukela oluyinkimbinkimbi), ukukhula kwabo kwancipha. Ukuze ukondle umdlavuza umuthi obulalayo, abacwaningi bakhiqiza imfucumfucu ye-hybrid eyenziwe ngoshukela olula no- n -butyrate. Ngenxa yokuthi amangqamuzana omdlavuza athatha ushukela kalula, ahlanganisa le molekyuli entsha, ephazamisa ikhono labo lokuqhubeka likhula, futhi bafa.
Amanye amaqembu ososayensi asebenzisa izidakamizwa ezizosizakala ngobuthakathaka bomdlavuza ushukela.
Ezinye zalezi zidakamizwa ezintsha zinganikezwa kanye ne-chemotherapy, ukwenza amangqamuzana omzimba azwele kakhulu izidakamizwa ze-chemo. E-Switzerland, ososayensi basebenzisa i-sugar coating "ama-quantum amachashazi" noma ama-nanocrystals wezidakamizwa ezizohamba esibindi kuphela, ukugwema ezinye izitho. Kuyinto ushukela kulawo amanani amancane okusiza izidakamizwa zibheke ingxenye ethile yomzimba, ngaleyo ndlela ukunciphisa imiphumela emibi futhi kwandise ukusebenza kwezidakamizwa.
Ukukhuluphala kanye neCanscer
Enye yezindlovu ekamelweni lapho ukhuluma ngoshukela nomdlavuza ukukhuluphala. Ukuba nezinyosi ezinomsoco nokudla ukudla okuningi okushukela kuhlobene nokukhuluphala, futhi ukukhuluphala kuhlobene nomdlavuza. Ukukhuluphala kwamanzi kuguqula amazinga e-hormone emzimbeni ahlotshaniswa nengozi enkulu yombili umdlavuza okhulayo futhi unomdlavuza oqhubekayo noma intuthuko. Ngokusho kwe-International Association for Research on Cancer, enye yezinto ezinhle kakhulu ongayenza kokubili ukuvimbela umdlavuza kuqala, nokuvimbela ukuphindaphinda uma usuvele utholakala ukuthi, uzobe uncike kakhulu kunokwenzeka ngaphandle kokuba unesisindo esiphansi.
Yiba Nge-Sugar Nge-Diet Yakho
I-Sugar inikeza amandla kodwa ayikunikezi izakhi ezidingekayo ukunciphisa ingozi yomdlavuza wakho. Ushukela wemvelo utholakala ezitsheni nasemikhiqizweni yobisi futhi kungaba yingxenye yokudla okunempilo. Ishukela engeziwe-uhlobo olwengezwa ekudleni, njengokweshukela omhlophe, isiraphu yamabele, kanye ne-juice ye-fruit concentrate-kufanele kugwenywe noma kungalinganiselwe. Ukudla amakholori amaningi ushukela kungabangela ukukhuluphala kanye namazinga aphezulu e-insulin, okuzofaka isandla engozini yomdlavuza owandayo. Gwema ukudla okunoshukela okufana noswidi, izimpahla eziphekiwe, okusanhlamvu okushukela nama-sodas ukunciphisa ingozi yomdlavuza wakho. Ukulinganisela ukudla kwakho nokudla okutshala, izinhlanzi, kanye nezinhlamvu ezigcwele - izingxenye zokudla okunempilo okuye kwahlanganiswa nengozi ephansi yomdlavuza.
Okubalulekile
Kungcono ukudla ushukela wemvelo nsuku zonke, ikakhulukazi uma beyingxenye yokudla okunomsoco, okufana nobisi noma izithelo. Ushukela ekudleni kwakho akubanga imbangela yomdlavuza. Ukushaywa yindlala kwamanye amaseli akho kashukela ngeke kubulawe noma kuvimbele umdlavuza. Ukugcina ukudla okunomsoco nokuzivocavoca njalo kungakunika isisindo somzimba enempilo kanye namazinga ajwayelekile e-insulin. Lona indlela enhle yokunciphisa ingozi yomdlavuza wakho.
Imithombo:
Duan, W., Shen, X., Lei, J. et al. I-Hyperglycemia, Isici Esinganakiwe Ngenkathi Yokuthuthukiswa Kwemdlavuza. I-Biomedical Research International . 2014: 461917.
IKakeri, R., Lepenies, B., Adibekian, A. et al. I-Vitro Imaging ne-Vivo Liver Ukubheja ngamachashazi we-Carbohydrate Capped Quantum. I-Journal ye-American Chemical Society . 2009. 131 (6): 2110-2.
Sampathkumar, S., Jones, M., Meledeo, M et al. Ukubhekisisa indlela yokuGlycosylation kanye ne-Cell Cycle: Umsebenzi wokuThukela-Oxhomekile we-Butyrate-Carbohydrates Cancer Prodrugs. I-Chemistry ne-Biology . 2006. 13 (12): 1265-75.