Izimpawu, Izimbangela, Nezokwelapha I-Mixed Cellularity Classic Hodgkin Izifo
Iyiphi isiliva ehlanganisiwe i-Hodgkin lymphoma, injani evamile, yini ebangela, futhi iphathwa kanjani?
Sibutsetelo
Isisindo samangqamuzana I-Hodgkin's lymphoma uhlobo lwesifo se- Hodgkin , umdlavuza wamangqamuzana angama-lymph. Luhlobo lwesibili oluvame kakhulu lwesifo se- Hodgkin , futhi cishe amaphesenti angu-15 kuya kwangu-30 kubo bonke abantu ababhekene neHodgkin lymphoma emhlabeni wesentshonalanga banalo hlobo.
Inani leziguli ezinalo hlobo lweHodgkin liphakeme kwezinye izingxenye zomhlaba ngaphandle kwe-United States, kuhlanganise ne-Asia. Kwezinye izindawo, uhlobo oluvame kakhulu lweHodgkin lymphoma.
Izici
I-cellularity Hlugkin ingasetshenziswa nganoma isiphi isikhathi, nakuba ivame kakhulu kubantu abadala phakathi kweminyaka engu-55 no-74, kanye nabantwana abangaphansi kweminyaka engu-14. Kuyafana kakhulu emadodeni nakwabesifazane. Izinga loluhlobo lwe-lymphoma livela ukuthi liye lahlehla ngezigameko phakathi kuka-1992 no-2011, kodwa lokhu kungenzeka ngenxa yokuthi i-lymphomas ihlelwa esikhundleni sokunciphisa ukwehla kweqiniso.
Kuvamile kubantu abanamasosha omzimba asebenza kabi, isibonelo, kubantu abane-HIV.
Izimbangela
Akuyazi ukuthi yini ebangela isifo seHodgkin , nakuba kunezici ezithile eziyingozi ezitholakale. Ngomumo oxubekile we-lymphoma kunezimo eziphakeme ze-Epstein-Barr ezikhona emangqamuzaneni omdlavuza, kodwa ososayensi basalokhu bangaqiniseki ngobuhlobo obuqondile phakathi kwe-lymphomas kanye nale gciwane obangela i-mononucleosis esithathelwanayo.
Izimpawu
Izimpawu ezisemqoka zezifo ezixubene nezifo zinezitho zamagciwane ezinwetsheni entanyeni, izimpumputhe nesisu.
Ezinye izitho zingenakwenzeka ukuba zibandakanyeke ngaleli fomu le-lymphoma kunezinye izinhlobo ze-lymphoma. Ngezifo ezixubekile, izifo ezingamaphesenti angu-30 zabantu zibandakanya uhlangothi lwabo, amaphesenti angu-10 umnkantsha wamathambo, amaphesenti amathathu kwesibindi, kanti amaphesenti angu-1 kuya kwangu-3 kuphela abantu ababandakanyeka kwezinye izitho.
Ukuxilongwa
Ukuxilongwa kwe-lymphoma kwenziwa nge- lymph node biopsy .
Ukwelapha
Abantu abaningi abanalo lymphoma bathola ukuthi banezifo ezisezingeni eliphezulu, ezibandakanya i-lymph nodes kokubili engxenyeni engenhla yomzimba nasesisu.
Kubantu abanesifo sokuqala , ukwelashwa ngokuvamile kuhilela ukuhlanganiswa kwe-chemotherapy kanye nokwelashwa kwemisebe.
Ngezifo ezisezingeni eliphakeme , ukwelashwa ngokuvamile kuvame uketshezi lwe-chemotherapy eside, futhi cishe akubandakanyi ukusetshenziswa kwe-radiation therapy. Iziphakamiso ze-Chemotherapy zixoxwe ngalesi sihloko ngokuphathwa kwe-Hodgkin lymphoma .
Kulabo abaphindaphindiwe nge-Hodgkin lymphoma, noma uma ukwelashwa kokuqala kwehluleka, kunezinketho eziningi. Enye ukusebenzisa i-salvage chemotherapy (i-chemotherapy esetshenziselwa ukunciphisa ivolumu kodwa ingelapheki umdlavuza) ilandelwa yi-chemotherapy ephakeme kakhulu ne-autologous stem cell transplant. Ezinye izinketho zingabandakanya ukusetshenziswa kwe- monoclonal antibody Blincyto (brentuximab, ) i- immunotherapy ne-checkpoint inhibitor, ukufakelwa kwe-stem cell cell, noma ukuhlolwa kwe-clinic.
Isibikezelo
Nakuba i-Hodgkin lymphoma exutshwe ngumdlavuza ohlukumezayo, ukubikezelwa kuhle kakhulu . Kuyinto efanayo nabantu abane- nodular sclerosing Hodgkin lymphoma , futhi bangcono kunabantu abane-lymphocyte yokunciphisa isifo se-Hodgkin.
Ukubhekana
Kungakhathaliseki ukuthi ukuchazwa kwesibindi, kuyesabeka ukuthola ukuthi unomdlavuza, Ngaphezu kwalokho, ukwelashwa ukubeka lolu hlobo lwe-Hodgkin isifo ekuxoxweni kungaba yinselele kakhulu futhi kukhishwe intela, futhi sifunda ukuthi ukucindezeleka akuyona umbono omuhle kubantu abane-lymphomas . Finyelela emndenini nabangani. Cabanga ngokujoyina iqembu lokusekela emphakathini wakho noma ku-intanethi. Futhi hlola lezi zeluleko ekubhekaneni ne-lymphoma
Imithombo:
Ansell, S. Hodgkin Lymphoma: Ukuxilongwa Nokunakekelwa. I-Mayo Clinic Proceedings . 2015. 90 (11): 1574-83.
I-Bienemann, i-K., i-Borkhardt, i-A., i-Klapper, i-W., no-Oschi. Isimo esiphezulu segciwane le-Epstein-Barr (EBV) -I-Hodgkin lymphoma enempilo kanye ne-Hodgkin lymphoma-efana ne-B-cell lymphoproliferations nephrofayli ye-EBV latency 2 ezinganeni ezine-interleukin-2-inducible T-cell kinase. I-Histopathology . 2015. 67 (5): 607-16.
I-Cancer: Izimiso Nokusebenza Kwe-Oncology 7th Edition. Abahleli: VT DeVita, S Hellman noSA Rosenberg. Ishicilelwe nguLippincott Williams noWilkins, ngo-2005.
Glaser, S., Clarke, C., Keegan, T., Shintsha, E., noDe Weisenburger. Amathrendi Yesikhathi Esikhathini Amanani E-Hodgkin Lymphoma Subtypes Histologic: Izingqinamba Zeqiniso Eqinisweni Noma Ukuthuthukisa Ukuzijwayeza Ukuxilonga? I-Epidemiology ye-Cancer Epidemiology Biomarkers and Prevention . 2015. 24 (10): 1474-88.
I-National Cancer Institute. Ukuqapha, i-Epidemiology, nohlelo Lokuphela Lokusebenza. I-Hodgkin lymphoma yama-classic ehlanganisiwe. Ifinyelele ngo-02/11/06. http://seer.cancer.gov/seertools/hemelymph/51f6cf57e3e27c3994bd5342/