Uma unomdlavuza wegazi njengengculazi noma i- lymphoma , kungokwemvelo ukuzwa ukucindezeleka noma ukukhathazeka. Le mizwa ingabangelwa ukukhathazeka ngekusasa, izinkinga zemali noma zomndeni, noma izinkinga zansuku zonke ezifana nokufika esikhungweni somdlavuza noma ukukhumbula ukuthatha imithi. Kungakhathaliseki ukuthi yini imbangela, ukucindezeleka kungaba nethonya empilweni yakho futhi mhlawumbe nasemiphumeleni yokwelashwa kwakho.
Ingabe Ukucindezeleka Kungabangela Cancer?
Phakathi neminyaka eminingi, izifundo eziningi zesayensi ziye zazama ukunquma ukuthi ukucindezeleka kungabangela umdlavuza, noma kwenze ukuba sikhule ngokushesha. Lapho umzimba ucindezeleka, ukhulula ama-hormone okucindezeleka njenge-cortisol kanye ne-adrenaline-hormone, okungenzeka ukuthi, esikhathini eside, yenza isimiso somzimba wakho sokuzivikela sigxiliwe (ungasebenzi futhi.) Yingakho ungabona ukuthi ngezinye izikhathi impilo yakho ngenkathi ungaphansi kwengcindezi enkulu, njengokuhlola isikhathi esikoleni noma ngaphambi nje kokuxoxwa komsebenzi, wehla ngesifo. Ososayensi bakholelwa ukuthi lokhu kukhishwa kwesimiso sokuzivikela kungenza umzimba ube nesifo sengculaza esinjenge-lymphoma.
Muva nje, abacwaningi baqale ukuphenya ubuhlobo phakathi kokucindezeleka kanye nezakhi zofuzo. Baye bathola ukuthi izimo ezicindezelayo zingabangela izakhi ezithile zegciwane ukuba zisebenze futhi ezinye zivinjelwe, okuholela ekushintsheni okungaba nomthelela ekukhuleni komdlavuza.
Ngokwesibonelo, isayensi inqume ukuthi i-hormone yokucindezeleka i-cortisol ingashintsha izakhi zofuzo zomzimba futhi iphazamise ikhono lamagciwane okucindezela isisu ukukwenza umsebenzi.
Ukucindezeleka Nemiphumela Yabantu abane-Cancer
Olunye ucwaningo olushicilelwe e-Ohio State University ngoSepthemba 2010 luhlolisise umthelela wokucindezeleka, kokubili ngokwengqondo nangokwenyama, emiphumeleni yokwelashwa komdlavuza.
Laba cwaningi bathole ukuthi ukucindezeleka emzimbeni, kuhlanganise nokuzivocavoca okukhulu, kusebenze iphrotheni ebizwa ngokuthi ukushisa komshini-factor 1, okwenza kusebenze elinye iphrotheni elibizwa nge-Hsp27. Ukuba khona kwe-Hsp27 kuye kwaboniswa ukuthi kungenzeka ukuvikela amangqamuzana omdlavuza ekufeni, ngisho nangemva kokuba i-DNA yabo ibonakaliswe yimisebe noma i-chemotherapy.
Nakuba lolu chungechunge lwezocwaningo lunentshisekelo, lungabuye ludideke futhi lukhuni ukuhumusha. Izihloko kunoma yikuphi kwalezi zifundo zizobe zinezinkinga ezihlukahlukene zokucindezeleka, ngakho-ke kungenzeka kanjani ukuba neqembu "lokulawula", okungukuthi, okungekho ukucindezeleka ukuqhathanisa nezinye izihloko? Kungenzeka kanjani ukuthi kunqume ukuthi imiphumela yamaselula ebonwayo ayibangelwa ezinye izici ezingozini engase zibe nazo? Ngenxa yalesi sizathu, ubudlelwano obuqondile phakathi komphumela wokucindezeleka nomdlavuza awukwazi ukufakazelwa.
Muva nje, izifundo ezengeziwe ziphakamise ukuthi ukucindezeleka kungalimaza ngokuthinta indlela yokubonisa okubandakanya kokubili ukuqhubeka nokusabalalisa (imetastasis) yomdlavuza.
Ukucindezeleka Ukuphathwa Kwegciwane Lesifo
Ukwazi ukuthi ngaphezu kokuthinta izinga lokuphila, ukucindezeleka kungathinta umphumela wakho ngomdlavuza, kubonakala sengathi ukucindezeleka kubaluleke kakhulu kunanini ngaphambili kubantu abaphila nalesi sifo.
Uma uhlala nomdlavuza, qala ngokuhlola lezi zinkinga zokucindezeleka ezingu-25.
Kodwa kuhle njalo uma ungakwazi ukubulala izinyoni ezimbili ngetshe elilodwa. Izindlela eziningana zengqondo / zomzimba zitholakale ukusiza hhayi kuphela ukuphatha ukucindezeleka ezigulini zomdlavuza kodwa zizuze labo abanomdlavuza nangezinye izindlela. Isibonelo, i- yoga yezigulane zomdlavuza , ukucabangela iziguli zomdlavuza , ukuxilonga iziguli zesifo somdlavuza , kanye ne- qigong yeziguli zomdlavuza kungasiza ekuphatheni ukucindezeleka ngenkathi kusiza neminye imiphumela ecasulayo esukela ekukhatheni kuya ebuhlungu obungapheli ku-chemobrain.
Imithombo:
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Kanagasabai, R., Karthikeyan, K, Vedam, K. et al. I-DNA Ukulimala Nezimpendulo Zokucindezeleka Kwamaselula Hsp27 Ivikela Amaseli Adenocarcinoma avela ku-UV-Indoped Apoptosis nge-Akt ne-21-Dependent Way of Survival. Ucwaningo lwe-Cancer Molecular . 2010. 8: 1399-1412.
ULutgendorf, S., Sood, A., noMnu Antoni. Izimpendulo ze-Host kanye nomdlavuza wokuqhubeka: izindlela zokubonisa izimpawu ze-biobehavioral kanye nokungenelela. I-Journal ye-Clinical Oncology . 2010. 28 (26): 4094-9.
U-Moreno-Smith, M., uLutgendorf, S., no-A. Sood. Impact yokucindezeleka emdlalweni we-metastasis. I-Oncology yesikhathi esizayo . 2010. 6 (12): 1863-81.
Nagaraja, A., Sadaoui, N., Dorniak, Pl, uLutgendorf, S., no-A. Sood. SnapShot: Ukucindezeleka Nezifo. I-Cell Metabolism . 2016. 23 (2): 388-388.e1.
Williams, J., Pang, D., Delgrado, B. et al. I-Model of Gene-Environment Interaction iveza ukuvezwa kwe-Gland Gene eguquguqukayo futhi yanda ukukhula kokuhlukumeza okulandela ukuhlukaniswa kwezenhlalakahle. Ucwaningo Lokuvimbela I-Cancer . 2009. Yenza: 10.1158 / 1940-6207.CAPR-08-0238.