Njengoba amangqamuzana egazi ethuthuka, "imindeni" ehlukene igxuma ephuma egazini edala ama-stem cells. Umzila weselula we-myeloid umelela umndeni onjalo. Amaseli esiteshini samaseli we-myeloid yilokho okuvela kumaseli ase-myeloid progenitor, futhi ekugcineni abe ngamaseli asebekhulile egazi, aboniswe lapha:
- Basophils
- Neutrophils
- Ama-Eosinophils
- I-monocytes (ekhona egazini)
- Ama-Macrophages (akhona amathissi ahlukene)
- I-Erythrocytes (amangqamuzana egazi obomvu)
Ngakho-ke, ngayinye yezinhlobo zamaseli ngenhla imelela umkhiqizo wokugcina noma umphumela wokukhula emndenini we-myeloid.
Umzila wesitokisi we-myeloid othintekayo "emilonyeni yezidakamizwa" ezinjenge- acute myelogenous leukemia (AML) , enezinombolo eziphezulu kakhulu zokuxilongwa ngonyaka, kanye ne-lemonemia engapheliyo (CML) , elandisa ngamaphesenti angu-6 660 ngonyaka e-United States.
Umqondo
Amaseli abomvu , amangqamuzana egazi amhlophe, nama-plateslet bonke baye balungiselela izidingo zokuphila, futhi bayashintshwa ngokuqhubekayo. Ama-cell stem cells - ahlala ikakhulu emangeni lamathambo kubantu abadala - ukwandisa futhi akhiqize abantu abahlukahlukene, noma imigqa yamaseli.
Wonke amangqamuzana egazi avuthiwe angalandela umndeni wawo emuva kohlobo olulodwa lweseli, i-hematopoietic stem cell (HSC) eningi kakhulu, into efana "no-Adamu no-Eva" kuwo wonke amangqamuzana egazi.
Lawa maseli amancane ahlukana - kokubili ukuze azithathele wona futhi enze "amangqamuzana angama-progenitor." Khona-ke phakathi kwezinzalo ze-HSC, kunezinhlobo ezihlukahlukene zamangqamuzana omlando: kukhona umlenze ovamile we-lymphoid nomsunguli ovamile we-myeloid. Le fologi emgwaqweni phakathi kwemigqa ye-lymphoid ne-myeloid iyinhloko.
Umlandeli ngamunye angabangela imindeni yayo ehlukene yamangqamuzana egazi. Amangqamuzana egazi amhlophe aziwa ngokuthi i-lymphocytes avela kuma-progenitors lymphoid, kanti amaseli egazi amhlophe ahlukene, amaseli egazi abomvu namaplatelets akhula avela kumaphrotheni we-myeloid. Amaseli omgogodla we-myeloid avame ukwenza amaphesenti ama-85% omnkantso, ngokuphelele.
I-Myeloid Malignancies
Ngokusho kwe-American Cancer Society, iziguli eziningi ezine-leukemia e-myeloid (AML) ezinamandla zinamaseli amhlophe amhlophe amaningi angenawo igazi, futhi alikho amangqamuzana egazi abomvu noma amaplatelets. Amangqamuzana amaningi egazi elimhlophe angase abe myeloblasts - evame ukubizwa nje ngokuthi ukuqhuma - okuyizingqamuzana ezenza igazi ezingavamile ukutholakala egazini elijikelezayo. La maseli asanda kusebenza angasebenzi njengamaseli egazi amhlophe ajwayelekile, avuthiwe.
Iningi leziguli ezine-leukemia ezingapheli (i-CML) zinamaseli amaningi amhlophe egazi amaningi amangqamuzana amaningi angaphambili, avulekile. Amanye alawa maseli amhlophe angase aphinde aqhume kodwa ngokuvamile akhona ezinombalwa ezincane kune-AML. Ngesinye isikhathi iziguli ze-CML zingabuye zibe nezinombolo eziphansi zamaseli abomvu abomvu noma amapulethi egazi.
Kuzo zombili i-AML ne-CML, inani lamaseli egazi lingase liphakamise i-leukemia, kodwa ukuxilongwa okucacile kudinga i-bone marrow biopsy kanye ne-aspirate nezinye izivivinyo.
Imithombo
Krumsiek J, Marr C, Schroeder T, et al. Ukwahlukana Kwama-Hierarchy of Proyelocy Myeloid Kukhokhwa Ngenethiwekhi Ye-Transcription Factor. PLoS One. 2011; 6 (8): e22649.
Eaves CJ. Ama-hematopoietic stem cells: imiqondo, izincazelo, kanye neqiniso elisha. Igazi . 2015; 125 (17): 2605-2613.
I-Orkin SH, i-Zon LI. Hematopoiesis: I-Paradigm Eguqukayo Ye-Biology Cell Stem. Iseli . 2008; 132 (4): 631-644.
Jagannathan-Bogdan M, Zon LI. Hematopoiesis. Ukuthuthukiswa (eCambridge, eNgilandi) . 2013; 140 (12): 2463-2467.
I-American Cancer Society. I-acute myeloid leukemia ihlolwe kanjani? Ifinyelele ngoDisemba 2015.
Williams, L. "Ukubuyekezwa okuphelele kwe-Hematopoiesis kanye ne-Immunology: Impikiswano ye-Hematopoietic Stem Cell Transplant Abamukeli" e-Ezzone, S. (2004) Ukufakelwa kwe-Hematopoietic Stem Cell Transplantation: I-Manual for Nursing Practice Oncology Inhlangano Yezobuhlengikazi: Pittsburgh, PA (pp.1- 12).