I-Prezcobix (i-darunavir + cobicistat) iyinhlanganisela ye-dose fixed antiretroviral esetshenziswa ekwelapheni i- HIV . Izingxenye ezimbili zezidakamizwa eziqukethe i-Prezcobix zithengiswa ngabanye e-Prezista (darunavir) naseTybost (cobicistat) .
I-pilisi eyodwa, ithebhulethi eyenziwe ngokubambisana inikeza ukulula okulula, okukodwa kwansuku zonke, ne-cobicistat ekwakheni ngokuphumelelayo nokulondolozwa ngokuhlushwa kwe-plasma ye-Prezista emzimbeni.
I-Prezcobix yamukelwa yi-US Food and Drug Administration (FDA) ngoJanuwari 2015 kubo bonke abagulayo abasha nabahlangenwe nakho abane-HIV-1.
Ifomu
Ithebhulethi ene-oblong egcwele ifilimu, enama-800mg we-darunavir no-150mg we-cobicistat, i-pink embala futhi ihlanganiswe ne "TG" ngakolunye uhlangothi "800" kolunye.
Isilinganiso
Ithebhulethi eyodwa ithathwa nsuku zonke ngokudla. I-Prezcobix ayikwazi ukusetshenziselwa yedwa kodwa kufanele ithathwe ngokuhambisana nenye noma ngaphezulu noma izidakamizwa ezithinta izidambisigciwane.
Imiyalo
Ngaphambi kokuqala, iziguli kufanele zihlolwe ukuze zihlolwe imvume yabo yokuqalwa kwama-creatinine njengoba i-Prezcobix ingase ibangele umsebenzi wezinso (izinso), ikakhulukazi ezigulini ezinezifo ezingasebenzi ezingaziwa noma ezingaziwa. Uma uqondiswa nge- Viread (i-tenofovir) - isidakamizwa futhi saziwa ngokubangelwa ukukhubazeka komonakalo kwezinye-kunconywa ukuba iziguli zihlolwe ukuvunyelwa kwe-creinine esilinganiselwe, i-glucose yomchamo, kanye ne-protein yomchamo.
Kunconywa ukuthi iziguli ezinolwazi lwezokwelashwa, ikakhulukazi lezo ezivezwe nge-HIV protease inhibitors , zinikezwa ukuhlolwa kokuphikiswa kwezakhi zofuzo ngaphambi kokuthatha i-Prezcobix. Uma ukuhlolwa kwe-genotypic kungatholakali, i-Prezcobix kufanele igwenywe noma ubani ovezwe ngaphambilini ku-HIV protease inhibitors.
Imiphumela Ejwayelekile Ejwayelekile
Esifundweni sesigaba se-III socwaningo lwabantu, izibalo eziningana zomuthi wezokwelapha ziye zabonakala uma usebenzisa i-Prezcobix. Izenzakalo ezivame kakhulu, ezibikwe ku-5% noma ngaphansi kweziguli, zazi:
- Uhudo
- I-nausea
- Rash
- Izinwele
- Ubuhlungu besisu
- Ukuvota
Ukuphikisana kwezidakamizwa
I-Prezcobix akufanele ithathwe ngezidakamizwa ezilandelayo noma izithako ze-herbal:
- Imithi elwa ne-anginal: Ranexa
- Imithi Anti-arrhythmic: Multaq
- Imithi ye-anti-cholesterol: Mevacor, Zocor
- Imithi yokulwa ne-gout: i-Uroxatral
- Imithi yokwelapha ngokweqile: Revatio
- Imithi ye-Antipsychotic: Latuda, Orap
- Imithi yokwelapha: I-Camptosar, i-Campto
- I-Ergot equkethe izidakamizwa zokulwa ne-migraine: DHE 45, Ergotrate, Hydergine, Migranal
- Imithi elwa namagciwane e-Rifampin: I-Mycobutin, i-Rifater, i- Rifamate, i-Rimactane, i- Rifadin, i-Priftin
- Ukuzijabulisa: Dormicum, Halcion, Hypam, Hyponvel, Trilam, Versed
- Wort St. John's Wort
Ukusebenzisana kwezidakamizwa ze-antiretroviral
Ukusetshenziswa kwe-Prezcobix ngezidakamizwa ezilandelayo ezidambisigciwane kungaholela ekulahlekelweni komthelela wokwelashwa kwesidakamizwa esilandelayo noma ingozi yokwanda kwemiphumela emibi:
- I-Crixivan (indinavir) akumele iqondiswe nge-Prezcobix.
- I-videx (didanosine) kufanele ithathwe ihora elilodwa ngaphambili noma ihora elilodwa ngemuva kokuthatha u-Prezcobix.
- Intelence (etravirine) akufanele iqondiswe nge-Prezcobix.
- I-Viramune (i-nevirapine) akufanele iqondiswe nge-Prezcobix
- Umthamo we-Selzentry (maraviroc) kufanele ulungiswe ku-150mg kabili ngosuku uma uqondiswa nge-Prezcobix.
Okunye ukusebenzisana noma ukucabangela
- Yazisa udokotela wakho nganoma yikuphi isimo esaziwayo noma esicatshangelwayo (isilwane) ongase ube nayo ngaphambi kokuqala i-Prezcobix.
- Imithi yokuphuza erectile (i-Viagra, i-Levitra, i-Cialis) kufanele isetshenziswe ngokucophelela njengoba i-cobicistat ingxenye e-Prezcobix ingakhuphula izinga lemiphumela emibi, okubandakanya ukuphazamiseka okubukwayo, ukuxilongwa, nokuzibamba (ukuhlunga okubuhlungu, okuqhubekayo). Kunconywa ukuthi i-Viagra isilinganiso sinciphile singaphezu kuka-25mg emahoreni angu-48; Izinga le-Levitra liye lahlehla lingabi ngaphezu kuka 2.5mg emahoreni angu-72, futhi isilinganiso se-Cialis sinciphile singabi ngaphezu kuka-10mg emahoreni angu-72.
Imithombo:
I-Bristol-Myers Squibb. "PREZCOBIX - ULWAZI LOKUPHILA OKUQHELEKILE." ENew York, eNew York