Ukungezwani komzimba ku-Prilosec, Prevacid, Nexium, Aciphex ne-Protonix
I-Proton Pump Inhibitors (i-PPIs) isetshenziswa imithi ejwayelekile yokwelapha isifo se-reflux ye-gastroesophageal (GERD) , isifo se-ulcer peptic , kanye nokwelashwa kwezifo. I-PPIs yenza ukuvimba amaphampu ase-acid esiswini, ngaleyo ndlela yehlisa ukukhiqizwa kwe-asidi, futhi isebenza kakhulu ekuphatheni izifo ezihlukahlukene ezihlobene nesisu ezihlobene nesisu.
Kunezinhlobo eziningi zeproton pump inhibitors ezitholakala emakethe, kuhlanganise omeprazole (Prilosec), esomeprazole (Nexium), pantoprazole (Protonix), rabeprazole (Aciphex) ne-lansoprazole (Prevacid). Ngokuvamile, i-PPIs imithi ephephile kakhulu nemiphumela emibi embalwa. Lokhu kungenzeka ukuthi i-omeprazole ne-lansoprazole iyatholakala ngaphezu kwe-counter / ngaphandle komshwalense (njengokungathi usuku lombhalo lulotshiwe, i-esomeprazole, i-pantoprazole, ne-rabeprazole itholakale kuphela ngomuthi).
Ukuthola Ukutholakala Kwesifo Sokungezwani Komzimba ku-Proton Pump Inhibitors
Ukusabela kwe-allergen kuya ku-proton pump inhibitors akuyona into evamile kodwa kwenzeka. Eziningi zalezi zindlela zifaka i- urticaria , i-asthma, ngisho ne- anaphylaxis . Ngokuvamile kunzima ukubona ukuthi i-PPI iyimbangela yokuphendula okwehlukile ngoba ezinye izidakamizwa, kuhlanganise ama-NSAID kanye nama-antibiotic afana ne- penicillin , avame ukunikezwa kanye nama-PPIs ukusiza ukuvimbela izilonda zesisu noma ukuphatha ukutheleleka kwe-Helicobacter pylori .
Ucwaningo oluningana oluye lwalwenziwa kubantu abaye babhekana nokuphendula okwehliswayo ngenxa yokuthatha i-proton pump inhibitors. Ukuhlolwa kwesikhumba , kufaka phakathi kokubili izindlela eziphambene nezimbangi, kwenziwa nge-PPIs (kanye neminye imithi umuntu ayithatha) okungenzeka ukuthi yabangela ukusabela okweqile.
Lezi zivivinyo zesikhumba zibonakala ziwusizo ekuboneni imbangela yokuphendula okwehlisiwe, ikakhulukazi uma i-PPI yimbangela. Izinselelo zomlomo ngokusebenzisa i-culprit PPI ziholele ekutheni izimpawu zemizwa ephikisayo lapho ukuhlolwa kwesikhumba kunempilo. Kodwa-ke, abantu ababenokuhlolwa kwezikhumba ezingalungile bebengakwazi njalo ukubekezelela i-PPI embukisweni ngesikhathi kunselelo lomlomo.
Ukuziphendulela phakathi kweProteton Pump Inhibitors
Ama-proton amaphilisi amahlanu ahlukene ahlulelanga isakhiwo samakhemikhali esifanayo, okusikisela ukuthi uma umuntu ephikisana nomunye i-PPI, enye noma amanye ama-PPI angase abekezelelwe. Ucwaningo olwenziwe ekusebenziseni isiphambano se-proton pump inhibitors lithole ukuthi abantu abaphikisana ne-omeprazole bavame ukuhlushwa i-pantoprazole (futhi ngokufanayo), futhi abantu abaphikisana ne-lansoprazole bavame ukuhlushwa i-rabeprazole (nangaphandle kwalokho). Lokhu kusetshenziselwa ukuphindaphindiwe kubangelwa izakhiwo ezifanayo phakathi kwama-PPI athile; ukungabi khona kwemisebenzi phakathi kwamanye ama-PPI kungavumela umuntu ukuthi angenele umuthi othile we-PPI ukubekezelela elinye i-PPI. Isibonelo, abantu abaphikisana ne-omeprazole noma i-pantoprazole bavame ukuthatha i-lansoprazole noma i-rabeprazole, futhi lezo zitholakale ku-lansoprazole noma i-rabeprazole zivame ukuthatha i-omeprazole noma i-pantoprazole.
Kubantu abaye bahlangabezana nokusabela okubangelwa ukwelashwa ngenxa yokuthatha i-proton pump inhibitor ethile, ukuhlolwa kwesikhumba kungase kube usizo ekuqinisekiseni ukuxilongwa. Uma ukuhlolwa kwesikhumba kumuntu ohlukumezekile ku-PPI kulungile, ukuhlolwa kwesikhumba ku-PPI okungenziwanga ngokuphambene nakho kungenziwa ngomzamo wokuthola i-PPI engakwazi ukuyibekezelela. Kodwa-ke, inselelo yomlomo, eyenziwa ngaphansi kokuqondiswa kwezokwelapha, kufanele yenziwe nge-PPI engahambisani nokuphikisana (nokuhlolwa kesikhumba esibi) ukuqinisekisa ukuthi ibekezelelwe ngokuphepha.
Funda kabanzi mayelana nokuxilongwa nokuphathwa kwezidakamizwa zokulwa nezidakamizwa .
> Imithombo:
> Bonadonna P, et al. Ukuziphendulela komzimba ku-Proton Pump Inhibitors: Ukunemba kokuthola izilinganiso zesikhumba kuqhathaniswa novivinyo lokuvuthwa komlomo. J Allergy Clin Immunol. 2012; 130 (2): 547-9.
> Chang YS. Ukusabela kwe-Hypersensitivity kuya ku-Proton Pump Inhibitors. I-Curr Opin Allergy Clin Immunol. 2012; 12: 348-53.
> Lobera T, et al. Amacala ayisishiyagalolunye okuthiwa i-Omeprazole yokungezwani. Ukuziphendulela phakathi kweProteton Pump Inhibitors. J Investig Allergol Clin Immunol. 2009; 19: 57-60.
> Perez Pimiento AJ, et al. Hypersensitivity kuya kuLansoprazole neRabrazole ngokubekezela kwezinye i-Proton Pump Inhibitors. 2006; 117 (3): 707-8.