I-Restless Leg Syndrome noma i-Willis-Ekbom Izifo

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Ukwehla kwe Iron

Nakuba abantu abaningi abanezinkinga zemilenze ezingenakuphumula (RLS) bangase bangakwazi ukubona imbangela yesifo sabo, ngokuvamile kubangelwa ezinye izimbangela eziyisisekelo. Lokhu kubangele izigaba ezimbili zesimo, i-RLS eyinhloko (yezizathu ezingaziwa futhi evame ukuhlala nomndeni) kanye ne-RLS yesibili. Kunezimo eziningi ezingase ziholele ngokuzimela emibhalweni ye-RLS.

Isimo sokuqala esingase sibangele izimpawu ze-RLS yi-iron deficiency. Ubuhlobo phakathi kokuntuleka kwensimbi kanye nezimpawu ze-RLS kuye kwafundwa kabanzi. Ezingxenyeni eziningi zocwaningo, amazinga aphansi ensimbi atholakale egazini nasemanzini omgogodla wabantu abahlukunyezwa yi-RLS. Amazinga we-iron aphansi, okubi kakhulu kunezimpawu. I-imagery ye-resonance magnetic (i-MRI) ibonise ukuthi okuqukethwe kwe-iron endaweni yengqondo ebizwa ngokuthi i-substantia nigra iyancipha kulabo abane-RLS uma kuqhathaniswa nabantu abavamile, okungabangela ukugula. Ngaphezu kwalokho, izifundo ze-pathological ziqinisekisile lolu shintsho ngaphakathi kobuchopho.

Ngakho-ke kunconywa ukuba ube nezinga lakho le-serum ferritin (uphawu lwezitolo zensimbi) oluhlolwe uma unezimpawu ze-RLS. Ngaphezu kwalokho, isilingo sokushintshwa kwensimbi ngomlomo uma amazinga aphansi kufanele kwenziwe. Ngisho nabanye abantu abanamazinga avamile baphendule kahle ekushintsheni kwensimbi.

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Isifo sokuphela kwesifo sezinso

I-RLS ivame kakhulu kubantu ababhekene nesifo sokuphela kwezinso , ikakhulukazi labo abaxhomeke ku-dialysis. Lesi sigameko siye sabikwa ukuthi sisukela kumaphesenti angu-6 kuya kwangu-60. Akucaci ukuthi yini engase ibe negalelo ku-RLS kuleli qembu. I-anemia, ukuntuleka kwensimbi, noma ngisho namazinga e-hormone e-parathyroid angase abe nendima esekelwe kwizifundo ezihlukahlukene. Kwezinye izimo, ukwelapha i-anemia nge-erythropoietin therapy noma ukushintshwa kwensimbi kuye kwaphumelela.

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Isifo sikashukela

Kubantu abaneThi 2 noma isifo sikashukela sokuqala, i-RLS ingahlakulela. Uma isifo sikashukela sishiywa singalawulwa, umonakalo wezinzwa ungabangela. Lokhu kucatshangwa ukuthi kwenzeka ngenxa yamazinga aphezulu e-glucose ngaphakathi kwegazi. Lokhu kungaholela ekulimaleni kwemithambo encane yegazi enikezela izinzwa ezibizwa nge-vaso nervorum. Lapho lezi zivale, le nerve ngokwayo iyolimala. Ngokuvamile lokhu kuholela ekutheni i-neuropathy ye-peripheral, equkethe ubuhlungu kanye nezikhonkwane-nezinaliti ukuzwa ezinyaweni. Lokhu kungathuthuka imilenze futhi kuhlanganise nezandla. Ehlangene nalezi zinguquko zengqondo, abanye abantu bazoba nezimpawu ze-RLS. Ngakho-ke, kucatshangwa ukuthi isifo sikashukela singase sibe yisisindo esizimele sokuthuthukisa i-RLS. Kubantu abaye babhekana ne-pancreas kanye nokuguqulwa kwezinso, izimpawu zabo ze-RLS zithuthukile.

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Multiple Sclerosis

Kunobufakazi obukhulayo bokuthi isibalo sabantu abaningi sibonakala sibhekene nengozi eyengeziwe ye-RLS. Ezinye zezifundo ziphikisana, noma kunjalo. Kwesinye sezifundo ezinkulu ezihlanganisa izifundo eziyi-1,500, ukusabalalisa kwe-RLS kwakungamaphesenti angu-19 kubantu abane-MS uma kuqhathaniswa namaphesenti amane kuphela alabo bantu abangenawo.

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Izifo zikaParkinson

Kucatshangwa ukuthi i-RLS ne-Parkinson isifo singabangelwa inkinga efanayo, okungukuthi ukuphazanyiswa ku-neurotransmitter dopamine. Lokhu akuqondwa ngokugcwele, noma kunjalo. Kungakhathaliseki ukuthi, i-RLS ingahle ibe khona kubantu abanesifo sika-Parkinson, esinesisindo esiphakathi kwamaphesenti angu-0 kuya kwangu-20.8, okuhluka ngokususelwa ekutadisheni. Isifo sikaParkinson ngokuvamile sihilela ukuzwa ukungabi naluzwa (okubizwa nge-akathisia) okuhambisana ne-RLS, okungenza kube nzima ukuhlukanisa phakathi kwezimpikiswano. Uma zombili izimo zikhona, i-RLS ngokuvamile ivele ngemuva kwesifo sika-Parkinson sesibonakala.

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Ukukhulelwa

Akuzona zonke izimo ezingase ziholele ku-RLS yiziphazamiso. Eqinisweni, ukukhulelwa kubonakala sengathi akukhulumi nje kuphela izigameko kodwa nezinga lezimpawu ze-RLS. Ekucwaningweni kwabesifazane abakhulelwe abangu-626, amaphesenti ayishumi kuphela anempawu ze-RLS ngaphambi kokukhulelwa kodwa lokhu kwanda ngamaphesenti angu-27 ngesikhathi sokukhulelwa. Kubonakala sengathi kubi kakhulu emithathu. Izindaba ezinhle ukuthi izimpawu ziphuthuma ngokushesha ngemva kokubeletha. Akucaci ukuthi yini ebangele imvamisa eyengeziwe ye-RLS ngesikhathi sokukhulelwa. Kungenzeka ngenxa yensimbi noma i-folate insufficient noma ngenxa yezinguquko ze-hormonal ezihlobene nokukhulelwa.

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Izifo Ze-Rheumatic

Kunezimo eziningi ezinjenge-arthritis ye-rheumatoid, isifo se-Sjogren, ne-fibromyalgia okungenzeka ibe nokuhlangana nezimpawu ze-RLS. Lobuhlobo abucacile. Kwesinye isifundo, amaphesenti angu-25 abantu abane-arthritis ye-rheumatoid anezimpawu ze-RLS uma kuqhathaniswa namaphesenti amane kuphela alabo abane-osteoarthritis. Kwesinye isifundo, iziguli ezingu-42 kweziyi-135 ezine-fibromyalgia zine-RLS. Isizathu esiqondile salesi sihlobo asiqondi kahle.

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I-Varicose Veins

Kwezinye izimo, igazi elibi eligeleza emilenzeni liye lahlanganiswa ne-RLS. Ngokuyinhloko, imithanjeni ebuthakathaka ephazamisayo futhi ingakhathazeki iye yalahlwa. Lezi zindebe ze-varicose zivame ukuhlanganiswa futhi zihlaza okwesibhakabhaka futhi zingase zibe uphawu lokungenakuthola ngokweqile. Esikhathini sokutadisha iziguli ezingu-1,397 ezinezinhlungu ze-varicose, abantu abangu-312 bakhononda ngezimpawu ze-RLS.

Ukwelashwa kwemivimbo ye-varicose kuboniswe ukuthi kuphumelele ekunciphiseni ezinye zezimpawu ze-RLS. I-Sclerotherapy yaholela ekuthuthukiseni kokuqala ngamaphesenti angu-98 abantu, ngosizo olugcinwe eminyakeni emibili ngamaphesenti angu-72. Imithi yokwelashwa, kuhlanganise ne-hyrdoxyethylrutoside, nayo iboniswe ukuthi iyasebenza ngokuthobeka.

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Ezinye izimo

Ngaphandle kwezimo ezichazwe ngenhla, kunezinye izinkinga eziningi ezibonakala zihlotshaniswa nezimpawu ze-RLS. Lokhu kufaka:

• Ukukhuluphala
• I-Hypothyroidism
• Umfutho wegazi ophezulu
• Isifo senhliziyo
• I-peripheral neuropathies
• Ukwehluleka kwe-Vitamin
• Ukudla ngokweqile kwe-caffeine
• Ushukela ophansi wegazi
• I-radiculopathy yamaLumbosacral
• I-stenosis yomgogodla
• Ukusetshenziswa kwe-mianserin (imithi yokucindezeleka)

Uma unezimpawu zemilenze ezingenalutho, ngenhlanhla kukhona imithi ephumelelayo esetshenziselwa ukwelashwa .

> Imithombo:

> Allen, RP et al. "Ukulinganisa kwe-MRI ye-Brain Iron ku-Patients With Restless Legs Syndrome." I- Neurology 2001; 56: 263.

> Connor, JR et al. Ukuhlolwa Kwama-Neuropathological Suggestic Brain Iron Acquisition in Restless Legs Syndrome. "I- Neurology 2003; 61: 304.

> Earley, CJ et al. "Okungajwayelekile kwi-CSF Izingxenyana zikaFerritin ne-Transferrin ku-Restless Legs Syndrome." I- Neurology 2000; 54: 1698.

> Kavanagh, D et al. "I-Restless Legs Syndrome kuma-Patients ku-Dialysis." Am J Kidney Dis 2004; 43: 763.

> Lee, JE et al. "Okubangela Ukuthuthukiswa Kwemigqa Yezinsipho Ezingenalutho Ezinganeni Eziphethwe Izifo Ze- Parkinson." I- Mov Disord ka-2009; 24: 579.

> Manconi, M et al. "Imilenze yezinyawo ezingapheli nokukhulelwa." I- Neurology 2004; 63: 1065. I-American Academy ye-Sleep Medicine. Ukuhlukaniswa Kwamazwe Omhlaba Kwezinkinga Zokulala. "Uhlelo lwesibili. 2005.

> Manconi, M et al. "Ucwaningo Lwe-Castic Control-Control on Restless Legs Syndrome ku-Multiple Sclerosis: Isifundo se-REMS" Ukulala ngo- 2008; 31: 944.

> Merlino, G. et al. "I-Association of Restless Legs Syndrome kanye nekhwalithi yokulala ngohlobo lwe-2 lwesifo sikashukela: isifundo sokulawula amacala." Ukulala ngo- 2007; 30: 866.

> Walters, A. "I-Restless Legs Syndrome ne-Periodic Limb Movements of Sleep." I- Continuum. I-Neurol 2007; 13 (3): 115-138.