Ingabe baphephile ukuphathwa kwe-asthma?
I-US Food and Drug Administration (FDA) inikeze isixwayiso kubaguli abathatha imithi efana neDulera, i-Advair, i-Symbicort, i-Breo, i-Foradil, ne-Serevent. Ucwaningo olulodwa, isilingo se-SMART, lubonise ingozi eyengeziwe yokufa kwesifo se-asthma nezinye izinkinga zokuphefumula uma kuqhathaniswa ne-placebo ezigulini ezithatha i-Serevent, ikakhulukazi ezigulini zase-Afrika naseMelika.
Ngenxa yalesi sizathu, i-FDA inikeze isixwayiso se-black-box kule mithi, izinga eliphakeme lokuxwayisa ngemithi i-FDA engayinika.
I-Serevent ne-Foradil yi-beta-agonists esebenza isikhathi eside (i-LABAs) esetshenziselwa ekwelapheni isifo se-asthma esincane. I-LABA ayinayo imithi yokwelapha eyaneleyo ngokwabo ngokwezifiso ze-asthma, futhi ingase ibangele ukuhlaselwa yisifo se-asthma lapho isetshenziselwa yodwa. Ngakho-ke, umuntu onesifo se-asthma kufanele ngaso sonke isikhathi asebenzise i- corticosteroid etholakalayo (njenge-Flovent, i-Pulmicort, i-QVAR) ekwelapheni i-asthma lapho kudingwa i-LABA. I-Dulera, i-Advair, i-Breo, ne-Symbicort iqukethe kokubili i-steroid engatholakali ne-LABA.
Ngeshwa, isilingo se-SMART asizange sibheke ukuthi isiguli esithile sithatha i-corticosteroid engatholakali ngenxa ye-asthma yabo - lokhu kwakuyisinqumo ngokuphelele sodokotela wesiguli. Iningi leziguli ezine-asthma ezinzima kakhulu azizange zithathe i-corticosteroid engatholakali uma zifakwa ku-LABA.
Lapho isifundo sibheka iziguli ezithatha i-corticosteroid engatholakali futhi i-LABA (njenge-Dulera, i-Advair, i-Symbicort ne-Breo iqukethe), akuzange kubonakale ingozi eyengeziwe yokuhlaselwa yisifo sofuba noma ukufa kwesifo se-asthma.
I-FDA manje ithi imithi ye-LABA ayifanele isetshenziswe uma umuntu one-asthma elawulwa yi-corticosteroid engatholakali yedwa.
Uma i-asthma ingalawulwa kwi-steroid engatholakali, ukhetho olwengeziwe lwezokwelapha luhlanganisa (a) ukwandisa umthamo we-corticosteroid engathintiwe (okungenzeka ibe nezingozi zayo) noma (b) ukungezwa kweminye imithi efana ne-LABA, Singulair , i-theophylline, i-prednisone yomlomo kanye / noma i- Xolair . Khumbula ukuthi i-asthma engalashwa nayo inezingozi zayo futhi, ezingabandakanya ukuhlaselwa okukhulu kwesifo se-asthma esiqinelayo .
Kubantu abaningi, izinzuzo ze-corticosteroid ne-LABA imithi (Dulera, Advair, Breo, ne-Symbicort) zidlula kakhulu izingozi. Kodwa-ke, kubalulekile kuwe ukwazi izingozi kanye nezinzuzo zale mithi ukuze wenze ukhetho olufanele. Uma usuvele usebenzisa imithi ye-LABA njengengxenye ye-therapy yakho ye-asthma futhi ukhathazekile ngokuphathelene nolwazi olungenhla, sicela ungabeki ukuphuza imishanguzo yakho yesifo sofuba kuze kube yilapho ukhuluma nodokotela wakho. Uma ukhetha ukungasebenzisi i-LABA njengengxenye yokwelashwa kwakho kwe-asthma, sicela uzise udokotela wakho ngalesi sinqumo ngaphambi kokuba unqabe imithi yakho ye-asthma.
Bheka izinhlamvu zexwayiso ze-FDA emithi equkethe i-LABAs.
> Imithombo:
> Aaronson DW. Isexwayiso "seBlack Box" kanye nezidakamizwa zokulwa nezifo. J Allergy Clin Immunol. 2006; 117: 40-4.Nelson HS, Weiss ST, uBleeker ER, et al. I-Salmeterol Multicenter Yokuhlolwa Kwengqondo Yokuziphendukela Kwemvelo. Isifuba. 2006; 129: 15-26.
> Nelson HS. Ama-Beta-Agonists asebekhulile e-Asthma yabantu abadala: Ubufakazi bokuthi lezi zidakamizwa ziphephile. I-Primary Respiratory Care Journal. 2006; 15: 271-77.