Imiphumela ye-Vitamin C MayiNcike Ku-Malignancy
Uma ucabanga ngokucindezeleka, mhlawumbe ingqondo yakho iphendukela esimisweni, izikhathi zokugcina, izivivinyo, ubudlelwano, noma ezinye izinselele umuntu angase abhekane nazo ekuphileni. Izwe lanamuhla alinaso ukushoda okubangelwa ukucindezeleka okungase kube ukucindezela.
Noma kunjalo, akuwona wonke umuntu ophendula ngendlela efanayo kulezi zimbangela zemvelo. Imithombo yokuhluka komuntu ngamunye kungenzeka iningi, ngokuyingxenye ngenxa yokwazi kwethu ukubhekana nokuphendula ngokuvumelana nemvelo yethu.
Kunokulingana kwamaselula nokucindezeleka, futhi. Njengoba nje singathola imvelo yethu ngokucindezeleka ngezinye izikhathi, imvelo yeseli ingase ibe nezinhlobo ezihlukahlukene zokubangela ukucindezeleka-ngokwesibonelo, i-molecule emangalisa emzimbeni ozungezile, noma ukungakwazi ukucubungula kahle ama-molecule wamangqamuzana angaphakathi.
Uma ucabanga ngamangqamuzana omdlavuza, ikakhulukazi, ungase ungawahlanganisi masinyane nalabo abasengozini yokucindezeleka. Amaseli omdlavuza avame ukuchazwa ngokwemigomo efana 'engenakunqotshwa' futhi 'engafi' ngokuthi abonakala ezala futhi esakaza ngaphandle kwemingcele. Kodwa-ke, kuvela ukuthi amangqamuzana omdlavuza asebenza ngaphansi kokucindezeleka okuningi ikakhulukazi, ukucindezeleka okwenziwe nge-oxidative. Futhi i-vitamin C ingadlala indima ebalulekile uma kuziwa kuma-enzyme athile asiza amangqamuzana aphendule ekucindezelekeni.
Kuyini Ukucindezeleka Oxidative?
Ukucindezeleka oxidative , ngokucacile, ukungalingani esimweni seselula.
Njengoba lo mqondo uphuthukisiwe, lokhu kungalingani kungabhekwa njengokulwa okungalingani phakathi kokukhiqizwa kwezitha eziyingozi (ama-radicals mahhala) kanye nekhono lomzimba ukulwa nemiphumela eyingozi yalesi sitha (nge-antioxidants).
Kungenzeka ukuthi ufunde ngama- radicals mahhala ekhemistini: ngokusemthethweni, bachazwa njengama-molecule engahlanjululwa ngokuvamile asebenza kahle futhi aphila isikhathi esifushane, ngama-electron angasebenzi.
Ngokwesibonelo, ama-molecule e-oksijini kuwo wonke umzimba ngezinye izikhathi ahlukaniswe ama-athomu angama-oxygen, ngalinye linamakhemikhali angasebenzi.
Ama-electron afuna ukuba ngamabili, ngakho-ke ama-athomu angalingani, manje ebizwa ngokuthi ama-radicals amahhala, afune amanye ama-electron ayingxenye yomzimba, cishe njengezilwane ezidliwayo, ukubhangqa ne-electron eyomunye umlekyu emzimbeni. Lokhu ukucindezeleka okwenzakalayo, futhi, kubangela ukulimala kwamangqamuzana, izinambuzane, amaprotheni kanye ne-DNA.
Ngakho-ke, kungani amangqamuzana omdlavuza ngokuvamile esebenza ngaphansi kwezinga eliphezulu lokucindezeleka okwenziwe nge-oxidative? Kakhulu, lawa maseli anamazinga aphezulu e-radicals mahhala ekuqaleni, kuqala, ngaphambi kokuthi abe nomdlavuza. Khona-ke, njengoba iseli lithatha izinyathelo ezengeziwe ukuze zibe nomdlavuza, izinto zivame ukushintsha ngendlela yokuthi leyo cell isebenza ngayo umzimba wayo, okungenzeka kuholele kumazinga aphakeme kakhulu e-radicals mahhala.
Ngokujwayelekile, kukhona ibhalansi phakathi kokukhiqizwa okukhululekile kokukhiqiza nokuqedwa. Kukhona amaqembu "amabili" ahlukene, neqembu elilodwa elikhiqiza ama-radicals amahhala afana ne-superoxide anion (O2-), i-hydrogen peroxide (H2O2), i-hydroxyl radicals (OH-), njll, kanye namanye amathimba ahlinzeka izindlela zokuvikela antioxidant [superoxide dismutase ( I-SOD), i-catalase (i-CAT), glutathione peroxidase (GPx), njll].
Lapho umlandi omkhulu okhululekile engabhalisiwe futhi / noma aqedwe, umphumela ungase ube umonakalo wamangqamuzana, ukulahlekelwa umsebenzi kanye nobuqotho be-membrane yeseli, kanye nokulimala kwe-DNA, ukugqugquzela izinguquko ezibangelwa izakhi zofuzo kanye nokukhula kwamangqamuzana okungalawulwa. Lesi siphetho sokugcina siyaziwa ukuthi asikho ukukhubazeka kwezakhi zofuzo, futhi singakwazi ukufaka uphethiloli emlilweni ngokuphathelene nohambo oluyingozi lweseli.
Ukucindezeleka kwama-radicals nama-oxidative nakho kuhlotshaniswa nezinkinga zezifo zabantu ngaphandle komdlavuza, kufaka phakathi isifo senhliziyo, isifo se-Alzheimer, isifo sika-Parkinson, nokuningi. Kukhona isixhumanisi sokuguga, ngokuqoqwa kancane kancane komonakalo omkhulu wamahhala.
Izinto ezikhiqiza ama-radicals mahhala zingatholakala emvelweni wethu, kufaka phakathi ukudla esikudlayo, kodwa futhi zenzeka emizimbeni yethu njengemikhiqizo yemvelo yokudalwa kwamanzi.
Izimo Ezinamandla Ezifana Ne-Vitamin C Zivikela Kanjani I-Cancer?
I-Vitamin C iye yahlolwa ezinhlobonhlobo ezahlukene zokwelapha nokuvimbela umdlavuza; Kodwa-ke, imiphumela ayisoze idwebe isithombe esicacile. Izimpendulo zemibuzo yendima ye-vitamin C ekuvimbeleni umdlavuza kanye nokwelapha ingase ithomeke ekuhlakalweni okuqondile-kanye nomthamo we-vitamin C, phakathi kwezinye izici.
Ezingxenyeni eziphansi, i-vitamin C inendima yokulwa ne-antioxidant, ivimbela ukukhipha isisindo. Ukudla okunama-antioxidant, okune-ascorbic acid (i-vitamin C), i-carotenoids (i-vitamin A) ne-tocopherol (i-vitamin E), i-selenium, ne-flavonoids, kunconywa ngenxa yesenzo sabo sokuphikisana sokuvimbela okushicilelwe nokukhiqizwa kwamahhala.
Kodwa-ke, amazinga aphezulu kavithamini C angakhuphula ukukhiqizwa kwe-ATP (okukhiqizwa yi-mitochondria) ekwehliseni ukufa kweseli ehleliwe ekuhlolweni kwesilonda se-tumor, nge-pro-oxidant mechanism.
Ucwaningo lubonisa umsebenzi olwa nomdlavuza oxhomeke emzimbeni obhekene nezinqubo ezihlukahlukene zeselula ezibandakanya ukufa kwe-cell program, ukujikeleza kwamaselula okukhulunywa ngawo, nokusabalalisa iseli, ukwanda komdlavuza wesilwane ekuhloleni kwelabhu okwelapha amangqamuzana omdlavuza nge-mitoxantrone (i-chemotherapy drug) kanye novithamini C .
Ingabe Kuyoba Nendima Yezinga eliphezulu I-Vitamin C e-Leukemia?
Kuze kube manje, ezinye izifundo ziphakamise umsebenzi ngokumelene nezinhlobonhlobo zamanomdlavuza, kodwa ezinye iziphakamiso zisho ukuthi i-vitamin C ingenza ukuthi i-chemotherapy ingasebenzi kahle.
Impendulo emifushane yombuzo ongenhla ingukuthi "mhlawumbe," futhi, "kungase kuxhomeke ku-leukemia." Kungase kubalulekile ukubheka i-vitamin C ezivela ezingxenyeni ezahlukene ngaphambi kokwenza iziphetho mayelana nokusetshenziswa kwayo kunoma yimuphi umdlavuza, kodwa ezinye Ukutholwa kokuqala kwezifundo ezisekelwe e-laboratory ze-hematologic malignancies kuyakhuthaza.
Ucwaningo lwe-2017 ngomphumela wevithamini C kuma cell leukemia lanyatheliswa ephepheni elithi "Umakhalekhukhwini." Esingenisweni sabo, abalobi baphawula ukuthi ubufakazi be-vitamin C njengokwelashwa okuphumelelayo komdlavuza kuye kwaqhubeka kuphikisana kuze kube manje.
I-Vitamin C Kwangathi Umthelela We-Enzyme Okubalulekile ku-Leukemia
Ngokuyinhloko, leli qembu labacwaningi lihlolisise izinguquko zofuzo ku-enzyme ebizwa nge-Tet (Ten Eleven Translocation) methylcytosine dioxygenase 2, noma i-TET2. Bathole ukuxhumana okuthakazelisayo ne-vitamin C kanye nale-enzyme-ukusebenzisana okwakubonakala kuthuthukisa ukwelashwa kwemithi ethile yomdlavuza. Lokhu kwakuyisifundo sezilwane, ngakho-ke lokho okushiwo abantu akukaziwa, kodwa imiphumela yayishukumisayo.
Emzimbeni, amangqamuzana amasha wegazi aphakama avela emangqamuzaneni akhethekile emnothweni wethambo okuthiwa i-hematopoietic stem cells . Ucwaningo olwandulelayo luye lwabonisa ukuthi i-TET2 enzyme ingenza la maseli avele akhule abe ngamaseli egazi aphile, avuthiwe, ajwayelekile-amangqamuzana agcina efa ngokufanayo nanoma yimuphi omunye umakhalekhukhwini. Ngokuphambene nalokho, e-leukemia, amangqamuzana amancane awakhuli kahle, kodwa kunalokho aphindaphindiwe ngokwawo, aphindwe ezinhlobonhlobo eziyingozi zamaseli e-copycat stem.
Umphumela we-leukemia engalawuleki ukukhula kwamaseli ukuvimbela umzimba ekukhiqizeni okwanele amaseli egazi ajwayelekile (isib. Ama-neutrophils, i-lymphocytes) ukuthi amasosha omzimba wethu adinga ukulwa nokutheleleka; ukunikezwa okunciphise kwamaseli amasha wegazi obomvu kungabangela ukuba i-anemia, futhi. Ngakho-ke, ukutholakala kokutheleleka futhi izinto ezinjengobuthakathaka noma ubukhulu obuvela e-anemia zingase zibe phakathi kwezibonakaliso nezimpawu ze-leukemia.
Kuvele ukuthi kwezinye izimo ze-leukemia, kuye kwaba nokuguqulwa kwezakhi zofuzo, noma ukuguquguquka, okuholela encwadini ye-Enzyme TET2 engasebenzi kahle. Ngakho-ke, ucwaningo luka-2017 luhlolisise indlela le enzyme, i-TET2, engase ivuselelwe ngayo ukwenza umsebenzi wayo, futhi ngokuphawulekayo, ngabe i-vitamin C ingasetshenziswa yini noma ayikho kulo mzamo wokubuyisela ukukhiqizwa kwe-cell cell.
I-Vitamin C TET2 Imiphumela Yokufundwa
Abacwaningi abafake izakhi zofuzo ukuze bavimbele i-TET2 enzyme, futhi bathola ukuthi uma i-TET2 ivaliwe, amaseli asematheni aqala ukungasebenzi, futhi lapho ephendulela igciwane, lezi ziphutha zaziguqulwa.
E-leukemia nezinye izifo zegazi ezingase zithonywe izinguquko zofuzo ezithinta i-enzyme ye-TET2, eyodwa kuphela yamakhophi amabili wegesi le-TET2 ishintshiwe. Ngakho-ke abaphenyi babheka ukuthi ingabe i-vitamin C ingase ikwazi ukwenza ikhophi engalungile, eguquliwe noma eguquguqukayo ngokukhulisa umsebenzi wekhophi esebenzayo ngokujwayelekile. Bathola ukuthi nge-vitamin C, kwakukhona ukuthuthukiswa kwendlela yokwenza izakhi ezabuyisela umsebenzi we-TET2.
I-PARP-inhibitors njenge-olapari yizidakamizwa ezifundiswa ukuthi kungenzeka ukuthi zisebenzise ezinhlotsheni ezahlukene ze-khansa yegazi kanye ne-leukemia. Kulesi sifundo, abacwaningi bahlanganisa i-vitamin C ne-PARP inhibitors kwisifanekiso sabo sezilwane ukuze bafunde ukuxhumana. Bathola ukuthi inhlanganisela yayisebenza kangcono, okwenza kube nzima nakakhulu ama-cell stem cells ukuba avuselelwe.
Kuthiwani Nge-Vitamin C e-Lymphoma?
Njengokuthola okutholakala ku-leukemia, ucwaningo lusezingeni lesandulela ngculazi, okusho ukuthi lokho esikwaziyo kubangelwa ukuhlolwa kwamangqamuzana nezilwane ezise laboratories, kodwa hhayi ngabanye ekuvivinyweni kwemitholampilo.
Noma kunjalo, zikhona, ngokusekelwe kule datha yangaphambi kwemitholampilo, izizathu zokukholelwa ukuthi okutholakele okuhlobene ne-TET2 ne-vitamin C kungase kusebenze okungenani kwezinye izimo ze- lymphoma .
Ku-lymphoma, ukuguqulwa kwe-TET2 kutholakala kakhulu kule-T-cell lymphomas. Enye ye-lymphoma subtype, i- angioimmunoblastic T-cell lymphoma , i-TET2 ingashintshwa ngamaphesenti angu-76 eziguli. Izinga lokuguquguquka kwe-TET2 liphakeme kakhulu kumaphesenti angu-38 weziguli ezine-T-cell lymphoma ye-peripheral-hhayi okuchazwe ngenye indlela, ngokusho kocwaningo olwenziwa yi-Lemonnier nozakwabo, namaphesenti angu-13 ku- B-cell lymphoma enkulu .
Izwi elivela
Nakuba ososayensi behlunga idatha ngokuphathelene nevithamini C kanye nendima yayo ekuvimbeleni nasekwelapha ukwelashwa okuthile, kubalulekile ukuba ulinganise ekudleni le vithamini. Kuningi kakhulu into enhle akuyona into enhle. Futhi, ngaso sonke isikhathi kuncono ukubonana nodokotela wakho lapho uqala noma iyiphi imitheshwana eyengeziwe engaphazamisa ukwelashwa kwakho.
Ayikho ubufakazi obusikiselayo ukuthi ukwengeza nge-vitamin C ngokwakho, ngaphezu kwalokho okunconywayo, kuzofinyelela ekuvikeleni noma okunye okuzuzisa ukuvuza kwegazi noma i-lymphoma, futhi ukuzihlola okunjalo kungabangela ukulimala ezimweni ezithile.
Esifundweni esedlule, kuye kwaboniswa ukuthi iziguli ezine-malmatancies ye-hematologic zingase zingabi nevithamini C. Ngakho, ukulungisa noma yikuphi ukutholakala kwevithamini C okungenzeka kube yindawo engcono kakhulu yokuqala.
> Imithombo:
> Cimmino L, i-Dolgalev I, Wang Y, et al. Ukubuyiselwa komsebenzi we-TET2 kuvimbela ukuzivuselela okuzenzekelayo nokuvuselela i-leukemia. Iseli . 2017 Aug 16. pii: S0092-8674 (17) 30868-1. i-doi: 10.1016 / j.cell.2017.07.032. [I-Epub ngaphambi kokuphrinta].
> Lemonnier F, Couronne L, Parrens M, et al. Ukuguqulwa kwe-TET2 okuphindaphindiwe ku-T-cell lymphomas yochungechunge ehambisana nezici ezifana ne-TFH kanye nemingcele yemilenze emimbi. Igazi. 2012; 120: 1466-1469.
> Mikirova N, Casciari J, Rogers A, et al. Umphumela we-dose ephezulu i-vithamini C enomzimba ngokuvuvukala kweziguli zomdlavuza. J Ukuhumusha Med . 2012; 10: 189.
> Shenoy N, Bhagat T, Nieves E, et al. Ukwehliswa komsebenzi we-TET nge-ascorbic acid kudala ukuguqulwa kwe-epigenetic kwamaseli e-lymphoma. I-Blood Cancer J. 2017; 7 (7): e587-. i-doi: 10.1038 / bcj.2017.65.