I-Niacin (i-nicotinic acid) imithi yokwehliswa kwe-cholesterol engathinta zonke izici zephrofayili yakho ye- lipid , Ngokuqondile, izifundo zibonise ukuthi i-nicotinic acid ingakwazi:
- Ukwandisa amazinga we- HDL ngamaphesenti angama-25%
- I-cholesterol engezansi ye- LDL nge-35%
- I- triglycerides engezansi ibe yi-50%
Nakuba ungathola i-nicotinic acid release (i-nicotinic acid) nge-odokotela, kunezinye izinqubo ze-niacin ezitholakalayo ngaphandle kwemithi kadokotela futhi zingabizi kakhulu.
Ngisho noma i-niacin ingase ingadingi ukuvakashela umhlinzeki wakho wezempilo ukuze uthole imithi kadokotela, lokhu akusho ukuthi kuphephile ngokuphelele ukuyithatha. Ucwaningo lwamuva, olukhulu (Ucwaningo lwe-AIM-HIGH) lwembula ukuthi abantu abanesifo senhliziyo basusa amazinga e-HDL akhulisiwe-kodwa abazange babone ukunciphisa ingozi yabo ebhekene nesenzakalo senhliziyo - njengesifo sokushaya noma senhliziyo - noma ukufa. Eqinisweni, akukho ukungafani okwashiwo phakathi kwabantu abakulolu cwaningo ukuthatha isimo se-statin ne-niacin ngokuthatha isithunzi se-statin yedwa. Ukwengeza, abantu abathatha i-nicotinic acid kulesi sifundo babe nesigameko esiphakeme semivimbo ye-ischemic. Ngenxa yokuthi kwakungekho ushintsho engozini yokufa noma izinkinga ezivela ezifweni zenhliziyo kanye nokukhathazeka ngenxa yokwanda kwezigameko ze-ischemic, abaphenyi bayeka lesi sifundo ekuqaleni.
Imiphumela emibi ejwayelekile ekhonjiswe nge-niacin ihlanganisa isikhumba, ukukhwabanisa, ukushisa okushisayo, nokushaya kwenhliziyo.
Kodwa-ke, eminye imiphumela emibi ingase ibe khona, futhi ingakhuphuka uma unesimo sezokwelapha ezilandelayo:
- I-Gout - i-Niacin ingakwandisa amazinga wakho we-uric acid, okwandisa amathuba okuba uhlaselwe isifo esibuhlungu.
- Isifo sikashukela - Abashukela ngesifo sikashukela esithatha i-niacin bangakwazi ukukhuphula izinga lokushukela kwegazi lokuzila ukudla.
- Isifo sesilonda se-Peptic - Izifundo ezihlola ukusetshenziselwa ukukhululwa kwe-nicotinic acid zinezincomo zokuthuthukiswa kwesilonda sezilonda. Indlela okwenzeka ngayo lokhu ayaziwa.
- Isifo sesibindi - Ukuthatha i-niacin kungabangela ukwanda kwama-enzyme yesibindi, okungaba ngaphezulu nakakhulu kubantu abatholakalwe benesifo sebindi.
- Isifo sezinso - Ukuba nomsebenzi omncane wezinso kungabangela ukuba i-niacin iqoqe egazini lakho, mhlawumbe nemiphumela emibi.
- Ukukhulelwa - Akuzange kube nezifundo ezanele ukuhlola ngokwanele ukuphepha kwe-niacin kumntanakho. Ngakho-ke, kufanele uthintane nomhlinzeki wakho wezempilo uma ukhulelwe, noma uhlela ukukhulelwa.
- Ukondla kwebele - Izifundo zibonise ukuthi i-niacin idonswa ngobisi lwebele, kodwa, aziwa ngokugcwele uma amanani ahlinzekwa ku-cholesterol ephansi angalimaza ingane.
- Isifo senhliziyo - Ukuthatha i-niacin kungadambisa izimo ezithile zenhliziyo, njenge-angina engazinzile.
- Ukuphazamiseka kwezibilini - Ukuthatha imikhiqizo yase-niacin kunganciphisa ikhono lakho lokuvala - futhi ukwandise ikhono lakho lokuphuma. Lokhu kungase kwenzeke uma uthatha ama-anticoagulants, noma "ama-blood thinners", njengeCoumadin (warfarin) noma i-aspirin.
Ekucwaningweni, abanye abantu abathatha i-niacin baqinisekisa ukunciphisa umthamo noma kubangele ukuthi i-niacin ivaliwe ngenxa yemiphumela emibi.
Ngenxa yemiphumela emibi engase ibe yingozi kanye nokuntuleka kwenzuzo emzimbeni we-cardiovascular, i-niacin ayinconywa njengemithi okufanele ithathe uma ufuna ukunciphisa amazinga akho e-lipid. I-Niacin cishe ingacatshangwa ngumhlinzeki wakho wezempilo uma ungakwazi ukulawula ngokugcwele amazinga akho we-lipid neminye imithi - njengokuthatha isitatimende sodwa noma isimiso se-statin ne-ezetimibe.
Ngakho-ke, uma ubheka ukufaka i-niacin ku-regid-downing regimen yakho, khuluma nomhlinzeki wakho wezempilo kuqala. Angase abe nezinye izindlela zokunciphisa ngokuvikelekile ama-cholesterol akho namazinga e-triglyceride, futhi kamuva angacabangela ukuthi i-niacin uma ezinye izindlela zokwelashwa zingasebenzi.
Imithombo:
I-Micromedex 2.0. I-Truven Health Analytics, Inc. I-Greenwood Village, CO. Itholakala ku-: http://www.micromedexsolutions.com. Ifinyelele ngo-Februwari 10, 2016
UDipiro JT, u-Talbert RL. I-Pharmacotherapy: Indlela Yokuthola Pathophysiological, 9th 2014.
Abaphenyi be-AIM-HIGH. I-Niacin ezigulini ezinezinga eliphansi le-HDL le-cholesterol futhi zithola ukwelashwa okunamandla kokwemigomo. N Eng J Med 2011; 365: 2255-2267.
Stone NJ et al. Imikhombandlela ye-ACC / AHA ka-2013 yokwelapha i-cholesterol yegazi ukunciphisa ingozi ye-atherosclerotic engqondweni yabantu abadala. Ukujikeleza 2014; Ukujikeleza 129 (25 Isondlo 2): S1-45