I-Welchol (i-colesevelam) imithi yokwehliswa kwe-cholesterol eyingxenye ye-bile acid resin yezidakamizwa. Ucwaningo lubonise ukuthi i-Welchol ngokuyinhloko ihlisa i-cholesterol ye- LDL ngamaphesenti angama-20 futhi iphakamisa kancane i- HDL nge-11%. I-Welchol ayibonakali iyathinta i- triglycerides futhi, kwezinye izimo, ingase ikhulise i-triglycerides uma ithathwa isikhathi esithile eside.
I-Welchol iboniswa futhi kubantu abanesifo sikashukela sohlobo lwe-2 ukuze babasize ukuba balawule amazinga egazi le-glucose kanye nabafana namantombazane angama-postmenarchal kuze kube yiminyaka eyi-10 ehlolwe ukuthi bane-heterozygous hypercholesterolemia.to yomndeni ekusizeni ekunciphiseni i-LDL cholesterol. Nakuba le mithi ibonise ukuthi iyasebenza ekunciphiseni i-LDL, ayizange iboniswe kwizifundo zokunciphisa ngokuqondile izifo zesifo senhliziyo.
I-Welchol iyatholakala ngezindlela ezimbili: ifomu eliyimpuphu kanye ne-tablet. Isidakamizwa savunyelwa ukusetshenziswa e-US yi-FDA ngoMeyi ka-2000.
I-Welchol isebenza kanjani?
I-Welchol isebenza ngokubophezela nge-bile acids emathunjini amancane nokuvimbela ukuphindaphinda kwabo. Ama-acid we-bile atholakala ku-cholesterol kanye nosizo lokugaya kwamafutha okudliwa ngokudla kwakho. Ama-acids e-bile aphelile ngenxa yokuboshwa ku-Welchol futhi awabuyiswa kabusha. Ngenxa yalokhu, i-cholesterol izosuswa egazini bese iguqulwa ibe yi-acid acids esibindi.
Lo msebenzi ususa i-cholesterol egazini - okwenza amazinga akho e-LDL cholesterol ayancipha.
Kufanele Uthathe Kanjani Welchol?
Kufanele uthathe uWelchol njengoba uqondiswa ngumhlinzeki wakho wezempilo. Lokhu kuzoxhomeka ukuthi iyiphi ifomu oyithatha i-Welchol.
Ngefomu elenziwe ngephunga le-Welchol, umthamo onconywayo ungamaphakethe angu-3.75-gram nsuku zonke, noma amabili, amaphakethe angu-1.875 amagremu athathwa kabili ngosuku.
Kufanele uchithe okuqukethwe kwepakethe engxenyeni eyodwa noma eyodwa yamanzi, soda yokudla, noma ijusi yethamo bese uxuba kahle. Okuqukethwe konke kwesiphuzo kumele kudliwe, ngokuhambisana nokudla.
Amaphilisi, umthamo onconywa ukuthatha amaphilisi ayisithupha ngesikhathi esisodwa nsuku zonke, noma uhlukaniswe njengamaphilisi amathathu kabili ngosuku. Amathebulethi kufanele athathwe ngokudla kanye nengilazi egcwele yamanzi.
Ubani ongafanele athathe i-Welchol?
Ngenxa yezingxenye zalo, kunezinye izimo lapho Welchol engafanele ithathwe khona. Lokhu kuzofaka:
- Abantu abaye babhekana nesifo esiphezulu ku-Welchol noma noma yiziphi izingxenye zayo.
- Noma ubani oke waba nesithiyo somzimba.
- Abantu abane-triglycerides ephakeme kakhulu (ekulu kunani noma elingana no-500 mg / dL), kusukela i-Welchol ingandisa amazinga akho okuba ne-triglyceride ngaphezulu. Ukwengeza, uma ukhonjiswe ngaphambili ukuthi unesifo sokudla ngenxa ye-triglycerides ephakeme, akufanele uthathe i-Welchol.
Iziphi Izimo Ezizodinga Ukuba Zibukwe Ngesikhathi Zithatha Welchol?
Kunezimo ezithile ezingase zidingeke zibhekwe ngokusondelene ngenkathi uthatha i-Welchol. Uma unemibandela elandelayo ngezansi, umhlinzeki wakho wezezempilo anganquma ukukuqala kuWelchol, kodwa kuzodingeka akuqaphele ukuthi unqume ukuthi u-Welchol ungayithathi yini noma cha.
Lezi zimo zezokwelapha zihlanganisa:
- Ukuba nobunzima ukugwinya. Amaphilisi e-Welchol akhulu kakhulu futhi angase kube nzima ukugwinya uma usuvele unezinkinga.
- Amazinga aphezulu e-triglyceride. Ukuba namazinga aphezulu a-triglyceride angeke akuvimbele ukuthi uthathe u-Welchol, kodwa umhlinzeki wakho wezempilo angase afune ukuqapha i-lipids yakho eduze kakhulu kusukela i-Welchol ingakhuphula amazinga wakho we-triglyceride.
- Izinkinga ezine-motility emaphethelweni akho emathunjini. I-Welchol ingabangela ukuqothulwa, ngakho lokhu kungase kuphumele eminye yalezi zimo.
- I-Welchol ihlukaniswa njengeNgxenye Yokukhulelwa B. Nakuba kungakaze kube nezifundo ezibanzi zokuhlola ukusebenza nokuphepha kwe-Welchol kwabesifazane abakhulelwe, izifundo zesilwane azizange zibonise umonakalo kumntwana. Njengoba lesi sidakamizwa singanciphisa ukumunwa kwamavithamini amanye, ezinye izingxenye zamavithamini angakabantwana angase asebenze ngenkathi ethatha i-Welchol. Umhlinzeki wakho wezempilo uyokwenza isinqumo ukuthi kufanele uthathe lesi sidakamizwa noma cha.
Yiziphi Imiphumela Ezingadingeki Ngilindele Ngesikhathi Ngithatha Welchol?
Imiphumela emibi yezinsizi yilezi zithandane ezivame ukubhekana nazo uma usebenzisa i-Welchol. Lokhu kufaka:
- Ukuvimbela
- Ukuguquka kwenhliziyo
- I-nausea
- Ukuzithoba
- Ukuqokwa
- Ubuhlungu besisu
Eminye imiphumela emibi, njengobunzima be-muscle nesifo somzimba, kuye kwabikwa futhi kwizifundo. Uma lemiphumela emibi iba yinkimbinkimbi, kufanele uvumele umhlinzeki wakho wezempilo ukuthi azi. Angakunika okuthile ukuphatha umphumela ohlangothini, ukulungisa umthamo wakho, noma ukushintshela kwenye imithi yokwehla kwe-cholesterol.
Imiphi Imithi Engayithinta Ne-Welchol?
Izidakamizwa ezilandelayo zingase zihlanganyele neWelchol ngokunciphisa inani lemithi elongene egazini lakho. Njengomthetho, cishe umqondo omuhle ukungathathi noma yimiphi imithi noma ukufaka amahora amane ngaphambi kokuthi noma amahora ayisithupha ngemuva kokuthatha noma yiliphi i-bile acid resin izidakamizwa, njenge-Welchol. Uma kudingeka ukuba uthathe esinye sezidakamizwa noma izithako ezibalulwe ngezansi, umhlinzeki wakho wezempilo uzodinga ukulungisa umthamo wakho noma isikhathi osithathayo, ukuqapha eduze kwakho nemiphumela emibi, noma ukuyeka ukusetshenziswa kwakho konke ndawonye:
- Amahomoni e-thyroid
- I-Lanoxin (digoxin)
- Amaphilisi okulawula ukuzala
- I-Verapamil
- I-Metoprolol
- I-Coumadin (i-warfarin)
- Amavithamini ama-soluble anamafutha (amavithamini A, D, E, no-K)
- Imithi yokwelapha, njenge-Dilantin (phenytoin) ne-phenobarbital
Lokhu akulona uhlu oluphelele, ngakho-ke kufanele uqiniseke ukuthi udalule yonke imithi enqunyiwe noma ngaphezulu, kanye nemikhiqizo yemvelo oyithathayo. Lokhu kuzokusiza umhlinzeki wakho wezempilo ukuba abone noma yikuphi ukuxhumana okungenzeka phakathi kukaWelchol neminye imithi yakho.
Ngaphansi
I-Welchol imithi esetshenziselwa ukunciphisa i-cholestolol yakho ye-LDL kodwa ayizange iboniswe ukunciphisa isifo senhliziyo esisencwadini. Ukwengeza, ngoba ifomu lePulchol lingenakulinganisa futhi amaphilisi angase anzima ukugwinya, kufanele uvumele umhlinzeki wakho wezempilo ukuthi wazi ukuthi unenkinga yokuthatha iWelchol. Ngenxa yokuthi i-Welchol ithinta kuphela izingxenye ezithile zephrofayli yakho ye-lipid, umhlinzeki wakho wezempilo angase afune ukungeza ezengeziwe zokwelapha eziphansi- njenge- statin noma i- fibrate .
Imithombo:
UDipiro JT, u-Talbert RL. I-Pharmacotherapy: Indlela yokuPathophysiological, 6th 2005.
ULacy CF, i-Armstrong LL, i-Goldman MP, et al. I-Lexicomp's Drug Information Handbook, ngo-15th ka-2007.