Izitatimende Zokunikezela Izindleko Ezincane Ezempilo Abagulayo
I-Statins yiwona ovame ukwelashwa kwe- cholesterol-ukwehlisa imithi ethinta zonke izici zephrofayili ye-cholesterol.
Izinzuzo zezimiso zihlanganisa:
- Ukunciphisa ama-LDL namazinga we-triglyceride
- Ukukhulisa amazinga we-HDL
- Ukunciphisa ingozi yesifo senhliziyo
- Ukuvimbela ukuhlaselwa kwenhliziyo okulandelayo nokushaywa kwezigulane ezigulini ezinesifo senhliziyo
Ngisho naphakathi kwezinzuzo ezithatha izitho zomzimba, ezinye iziguli zizishiya ngoba zicabanga ukuthi imiphumela emibi ingabangela ukulimala kunokuhle.
Ingabe iziguli zilungile ukugwema izitho zomzimba ngenxa yemiphumela emibi?
Sizuze kakhulu kakhulu iziguli ezinempilo
Izitatimende zingasiza iziguli ezinomlando wesifo senhliziyo, kodwa ukujwayela ukubeka iziqu zezitshalo kubantu abanempilo ukunciphisa ingozi kungase kuphele ekukhanyeni komhleli we-2015 oshicilelwe encwadini yezokwelapha ye-Prescriber. Umbiko uthi ngemuva kokuthatha ama-statins iminyaka emihlanu, amaphesenti angu-0.5 kuphela abantu abaphilile abagwema ukuhlaselwa yinhliziyo noma isifo sohlangothi. Ababhali, i-cardiologist yaseLondon kanye noprofesa odokotela wase-US, bacela ukubhalwa kabusha okuphelele kwemikhombandlela yaseMelika naseBrithani.
Ukuphakama kwesibindi se-Enzyme kuyisimo esibi samaSitatimende
Zonke izidakamizwa ze-statin ziphakamisa ama-enzyme yesibindi ngezinga elithile, kufaka phakathi i-aminotransferase (AST) ne-alanine aminotransferase (ALT), lapho umhlinzeki wakho wokunakekelwa kwezempilo ehlola ngaphambi kokuba uqale ukwelashwa kwesimo somzimba, izinyanga ezintathu emva kokuqala izitho zomzimba, futhi okungenani njalo ezinyangeni eziyisithupha ngenkathi kutholakala ukwelashwa kwesimiso.
Labo abanama-enzyme ephakeme wesibindi bangase bangaboni izimpawu.
Ukulinganisa okujwayelekile kwama-statins okuphakamisa ama-enzyme yesibindi ngamaphesenti angu-1 weziguli, ngokuvamile ezinyangeni ezine zokuqala. Amathuba okuphakama lokhu akhula kubantu asebekhulile nalabo abathatha ezinye izidakamizwa ezingase zisebenzisane nama-statins noma ziphinde ziphakamise ama-enzyme yesibindi.
Lesi sici se-statin side sixhomeke emzimbeni, okusho ukuthi ukuphakama kwesilinganiso sezinhlavu ozithathayo, cishe uzothola ukwanda kwama-enzyme yesibindi.
Kukhona imibiko engavamile yokuhluleka kwesibindi kanye nesifo sofuba esibangelwa ama-statins kanye ne-enzyme yesibindi ephakeme. Ucwaningo lwamanje alukwazanga ukusungula isixhumanisi esiqondile phakathi kokusetshenziswa kwesimiso nesifo sesibindi.
Izinga le-enzyme eliphakeme le-fox libuyela emuva evamile uma uyeka ukuthatha izitho zomzimba.
Ubuhlungu be-Muscle kanye nobuthakathaka kuyisici esisodwa samaSitatimende
Ezinye izibonakaliso ezinjengobuthakathaka nobuhlungu, izimpawu ze-Myopathies, noma ezinye izimpembelelo, zikhona ezinye izimpembelelo zomzimba zesimiso.
Ama-myopathies avela kuma-myalgias amancane, noma ubuhlungu be-muscle , esimweni esisongela ukuphila esibizwa ngokuthi i-rhabdomyolysis. I-myopathy evame kakhulu ehambisana nesimo se-statin, i- myalgia , ivele kuphela ku-1 kwabangu-1 000 iziguli ezithatha izitho zomzimba.
Ithuba lokubhekana nalomphumela we-statin side side ukwandisa njengoba ukhula, ngezinga eliphezulu futhi ngesikhathi uthatha ezinye izidakamizwa. Lezi zimpawu zizovela ezinyangeni ezine zokuqala ukwelashwa kwesimiso.
I-Rhabdomyolysis, enye i-myopathy engenzeka ngokusetshenziswa kwesimiso, ingavamile kakhulu futhi iyingozi uma ingaphathwa kahle. Kwenzeka kumuntu oyedwa kwabangu-10 000 abathatha izitho zomzimba.
Izimpawu ze-rhabdomyolysis zifaka:
- Ubuhlungu obukhulu besisu
- Ukungabi namandla
- Ukwandisa ngokuphawulekayo amanani e-creatinine phosphokinase
Ingabe Izinzuzo Ziyadlula Izingozi?
Lesi yisinqumo wena nomhlinzeki wakho wezempilo okufanele ukwenze.
Uma uthatha ama-statins esimweni sezempilo samanje, mhlawumbe imiphumela emibi ehambisana nokusetshenziswa kwesimanje ayinqamile ngokwanele uma uyiqhathanisa nezinzuzo.
Uma umhlinzeki wakho wokunakekelwa kwezempilo ephakamisa iziqu njengesimiso sokuvimbela, qiniseka ukuthi kokubili unayo yonke imininingwane oyidingayo, kufaka phakathi okutholakele okusha, ukwenza isinqumo esinolwazi.
Imithombo:
I-Armitage J. Ukuphepha kwama-statins emisebenzini yomtholampilo. I-Lancet . 2007; 6736 (07): 60716-8.
UDenus S, uSpinler SA, uMiller K, et al. Izitatimende nesifo sobindi: ukuhlaziywa kwe-meta. Pharmacotherapy . 2004; 24 (5): 584-591.
U-Harper CR no-Jacobson TA. I-spectrum ebanzi ye-statin myopathy: kusuka ku-myalgia kuya kwi-rhabdomyolysis. I-Curr Opin Lipidol . 2007; 18 (4): 401-08.
Jacobson TA. Ukuphepha kwe-statin: izifundo ezivela kwizicelo ezintsha zezidakamizwa zezimpawu ezimakethe. Am J Cardiol . 2006; 97 (8A): 44C-51C.
I-Spencer B. Imeyili Yansuku zonke: Iziguli Ezinempilo Ezisebenzisa Izitatimende Kungenzeka Kakhulu Ukuhlupheka Kwezingxenye Zemizwa-Ukuthola Izinzuzo Zempilo '