I-Melatonin nokuthi ingasiza kanjani nge-Sleep and Sundowning Problems ku-Alzheimer's
Isifo se-Alzheimer isifo esibulalayo, kodwa ukwelashwa okuyingqayizivele efana ne-hormone melatonin ingakwazi ukuthuthukisa izimpawu ezinzima ezifana nokulala nokushona kwe-sundowning.
I-Alzheimer ne-Melatonin
I-Melatonin inezindima eziningi emzimbeni, kodwa kubaluleke kakhulu ekulawuleni kokulala. I-Melatonin ikhiqizwa ebuchosheni yi-pineal gland. Le gland ikhipha izinga layo eliphakeme le-melatonin kusihlwa, futhi i-hormone ibonakala iyinsiza ekusweleni kwezinguquko esizibiza ngokuthi zilele.
Sekuyisikhathi eside ucwaningo selusungula ukuthi amazinga e-melatonin ayancipha ngokweminyaka, kodwa abantu abanesifo se-Alzheimer banamazinga aphansi kakhulu - ngezinye izikhathi abayingxenye eyodwa kuphela njengabantu abaneminyaka efanayo abanalo isifo. Futhi, ukuphazamiseka kokulala ngokuvamile kuyisibonakaliso sika-Alzheimer's. Eminyakeni yamuva, izifundo eziningi ziye zabika izinzuzo ze-melatonin eyengeziwe, hhayi kuphela ekunciphiseni izinkinga zokulala ezihlobene ne-Alzheimer, kodwa futhi nokushona kwelanga.
I-Sundowning ibhekisela ekuphazamiseni okuziphatha okujwayelekile kakhulu esifweni se-Alzheimer futhi kuvame ukuba khona kusihlwa. Ngenxa yezizathu ezingekho ngokucacile, abantu abaningi abanombukiso we-Alzheimer banda ukudideka , ukukhathazeka , ukukhathazeka ngisho nokuhlukunyezwa ekupheleni kosuku. Ngokusho kwe-Alzheimers's Association, cishe abantu abahlanu abanesifo se-Alzheimer bazobhekana nezikhathi zokushona kwelanga, ngokuvamile ezigabeni eziphakathi zesifo.
I-Sundowning ithatha inkokhelo kulabo abane-Alzheimer futhi banomthelela omkhulu ekucindezelekeni nasekukhathazeni. Ngenhlanhla, kunobunye ubufakazi bokuthi i-melatonin ingasiza ekusikeni kwelanga kanye nokuphazamiseka kokulala okuhlobene.
Ezinye izinzuzo zikaMelatonin ku-Alzheimer's
I-Melatonin ingahle ibe nezinye izinzuzo. I-antioxidant enamandla, eyenza ukulwa nokusebenza kwamakhemikhali okulimazayo okungalimaza amaseli.
Kubonakala sengathi kunezimpawu ezithile ze-neuroprotective, okusho ukuthi kusiza ukuvikela amangqamuzana obuchopho nobuchopho kusuka kumonakalo. Kukhona nobufakazi bokuthi ukungakwazi ukusebenza kwe-melatonin kuthatha indima ekucindezelekeni.
Ucwaningo oluthile lubonisa ukuthi i-hormone ingathuthukisa ukukhubazeka okungenangqondo , nakuba abacwaningi begcizelela ukuthi umphumela ulinganiselwe nokuthi i-melatonin ayilona "ukwelashwa" kwesifo so-Alzheimer esigcwele. Abanye abacwaningi bayacwayisa ukuthi umthelela we-hormone wawuyoba kancane ekupheleni kwe-Alzheimer's .
Abacwaningi sebeqalile ukuthuthukisa "i-melatoninergic" noma izidakamizwa zohlobo lwe-melatonin ezisebenza isikhathi eside futhi zibe nezinhloso eziqondile. Ngokwesibonelo, i-Rozerem (ramelteon) inqobe ukugunyazwa kwe-FDA yokwelapha kwesikhashana sokuphazamiseka kokulala. Kodwa kuze kube manje, akukho mithi yokwelapha i-melatonin eyenzelwe ngokuqondile isifo se-Alzheimer noma sundowning.
Ngaphansi
Izifundo ezingaphezulu zesayensi kufanele zenziwe ngokusebenzisa ukuxhaswa kwe-melatonin kwisifo se-Alzheimer ukuqonda ngempela inzuzo yaso yangempela (noma cha).
Kodwa njengoba i-melatonin ihlelwa njengesengezo, itholakala ngaphandle kwemithi. Lokhu kuthiwa, ngaphambi kokuba unike i-hormone kumuntu onesifo se-Alzheimer, kufanele uthintane nomdokotela wakhe, ozokwazi ukuthola ukuthi kunengqondo yini.
Imithombo:
I-Alzheimer's Association. "Izinkinga Zokulala Nokuzibulala
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QAPHELA: Ulwazi olukulesi sayithi lunguzinhloso zemfundo kuphela. Akufanele isetshenziswe njengengxenye yokunakekelwa ngumuntu udokotela olayisenisi. Sicela ubheke udokotela wakho ukuze ahlolwe futhi aphathwe noma yiziphi izimpawu noma isimo sezokwelapha .