I-angiotensin-ukuguqula i-enzyme (ACE) inhibitors yindlela yokuqala yokuzivikela ekwelapheni ukuhluleka kwenhliziyo ye- congestive (CHF), isimo esisongela impilo lapho inhliziyo ingasiphuli igazi elanele ezithombeni.
Indlela Abasebenza ngayo
Isetshenziswe ngempumelelo iminyaka engaphezu kwengu-20, i-ACE inhibitors yenza kancane ukuqhubekela phambili kwe-CHF ngezindlela ezintathu:
- Bavimbela i-enzyme eyenza imithwalo yegazi, eyanciphisa ukucindezelwa kwegazi futhi ihambisa igazi elengeziwe enhliziyweni, okwenza kube lula ukusebenza.
- Basinciphisa inani losawoti namanzi emzimbeni, okunciphisa nokucindezelwa kwegazi.
- Bavimbela ukukhiqizwa kwezinto ezibizwa nge-angiotensin, okwenza izitsha ziqine futhi ziphakamise ukucindezelwa kwegazi.
Izinhlobo
Ama-inhibitors e-ACE, njenge-Vasotec (i- enalapril ) ne-Capoten (i-captopril), evame ukushiwo ukuhluleka kwenhliziyo ukunciphisa amathuba okuhlaselwa kwenhliziyo nokushaywa isifo.
Sekuyiminyaka, ukwelashwa okuhlanganiswa ngenqubo yokwelashwa kwenhliziyo - ukuhlanganisa ama-ACE inhibitors ane-angiotensin II receptor blockers (ama-ARB) - yindlela ekhethiwe. Kodwa isihloko se-2007 kwi-American Diabetes Association sika- DOC News sigcizelele ukuthi abesifazane, ikakhulukazi, bathola inzuzo enkulu kuma-ARB. Ngemuva kwalokho, ucwaningo olunzulu luka-2008 eNew England Journal of Medicine lwaluqinisekisa ukusebenza kwe-ACE inhibitors, nama-ARB asala ukukhetha kwabanye.
Imiphumela emibi kanye nokusebenzisana kwezidakamizwa
Ekuqaleni, iziguli zingatshelwa ukuthi zithathe lesi sidakamizwa ngesikhathi sokulala ukunciphisa noma yikuphi ukuzulazula kokuqala okubangelwa ukuncipha kwengcindezi yegazi.
Ezinye imiphumela ezivamile ezivamile zibandakanya:
- Ukuphikelela, ukukhwehlela owomile
- Ubuthakathaka, isizungu
- Ukhathazeka ngesisu, ukufisa ukudla
- Ukuphuza isikhumba
- Ukunambitheka kwe-Metallic emlonyeni
- Amazinga aphezulu e-potassium
- I-nausea nekhanda
Imiphumela emibi kakhulu
Imithelela emibi kakhulu ifaka phakathi ukukhathazeka, umkhuhlane, ukukhukhumeza, ukuvuvukala kombuso kanye nesisu esicasulayo.
Tshela udokotela wakho uma uthola noma yikuphi kwalokhu, kepha ungayeki ukuthatha imithi ngokwakho. Ama-ARB afana ne-Cozaar (i-losartan) angahle anqunywe iziguli ezinezimo ezinzima kuma-ACE inhibitors.
Abesifazane abakhulelwe noma abancancisayo, noma labo abahlela ukukhulelwa, akufanele bathathe i-ACE inhibitors. Futhi, uma unesifo sikashukela , i-lupus, noma inhliziyo, isifo noma isibindi, noma uma uhlaselwa yinhliziyo yakamuva noma ukufakelwa kwezinso, udokotela wakho angase angafuni ukubeka i-ACE inhibitors.
Ukuhlanganisa ama-inhibitors e-ACE nokuphuza utshwala kungabangela umfutho wegazi ophansi ngokuyingozi. Izithako ezithile zemithi kanye nemithi, kuhlanganise ne-diuretics (amaphilisi amanzi) kanye nezidakamizwa ezine-potassium, ingathinta futhi isenzo se-ACE inhibitors. Qinisekisa ukuthi udokotela obeka ama-inhibitors wakho we-ACE unolwazi oluphelele lwawo wonke umuthi wakho.
Imithombo:
"I-ACE Inhibitors: Isifinyezo sezincomo." consumerreports.org. 2008. Abathengi.
"I-Angiotensin-Ukuguqula i-Enzyme (ACE) Inhibitors." texasheartinstitute.org. Jul 2007. I-Texas Heart Institute.
Abaphenyi Bama-PeaCE Trial. "Ukuguqulwa kwe-Angiotensin-Ukuguqulwa kwe-Enzyme ku-Stable Coronary Artery Disease." I-New England Journal of Medicine 351: 20 (2004): 2058-68.
UMthetho, uBridget Murray. "Ama-ARB aphuma ngaphandle kwe-ACE Inhibitors e-Women With Heart Failure." I-DOC Izindaba 4:11 (2007): 10. I-American American Diabetes Association.
"Imithi Evame Ukusetshenziselwa Ukwelapha Ukuhluleka Kwenhliziyo." americanheart.org . 9 Jan. 2008. American Heart Association.
Scow, uDean Thomas, u-Ellen G. Smith, no-Allen F. Shaughnessy. "Ukwelashwa Kokuhlanganiswa Nge-ACE Inhibitors nama-Angiotensin-Receptor Blockers enkingeni Yezinhliziyo." I-American Family Physician 68: 9 (2003): 1795-98. 4 Nov. 2008..
Abaphenyi be-ONTARGET. "I-Telmisartan, uRamipril, noma Bobabili Ezigulini Ezisezingeni Eliphakeme Lemicimbi Yezintambo." I-New England Journal of Medicine 358: 15 (2008): 1547-59. 4 Nov. 2008.