I-antigen ye-Cancer 27.29 (i-CA 27.29) ihlolwa ngegazi eyenziwa ngokukhethekile kubantu abanomdlavuza webele. Ngenye yezimpawu zomdlavuza webele womdlavuza ongasetshenziswa ukuqapha inkinga yesifo. Inguqulo eyodwa yalokhu kuhlolwa ibizwa ngokuthi "i-truquant BR radioimmunoassay test."
I-CA 27.29 i-antigen-okungukuthi, uhlobo oluthile lwamaprotheni alukhona emkhatsini wamangqamuzana futhi lukhiqizwa isakhi esibizwa nge-MUC-1.
I-CA-27 iyi-"glycoproteins," (i-glyco isho ushukela) futhi ingaba khona emangqamuzaneni e-epithelial afana namaseli omdlavuza webele. Amaseli omdlavuza webele webele angaphala amakhophi weprojekthi ye-CA 27.29 engena egazini.
Igazi le-CA 27.29 isilinganiso ngokuvamile ngaphansi kuka-U / ml. Njengoba unomdlavuza, amazinga ka-Ca-27 angakhuphuka, inani eliphakeme kakhulu, amathuba okuba lokhu kungabonisa ukuba khona komdlavuza.
Sibutsetelo
Kungasiza ukudiliza izindlela ezahlukene lapho kuhlolwa khona ukuhlolwa kwe-CA 27.29 ye-biomarker:
- Ukuxilonga-Lokhu kuhlolwa akuvame ukwenziwa ukuhlolisisa umdlavuza webele , okungenani hhayi wedwa. Kukhulunywe lapha ukuze kubhalwe ukuthi ukuhlolwa kwe-CA 27.29 kuphela ukuhlolwa kwegazi okusetshenziselwa ngokukhethekile ukucacisa ukuba khona kwamaseli omdlavuza webele. Uma unayo noma ucabanga ukuthi ungaba nomdlavuza webele wekusasa ekuqaleni, lokhu kuhlolwa kungenziwa ukuze kusize wenze ukuthi uhlolwe.
- Ukuqapha ukwelashwa-Ukuhlolwa kwe-CA 27.29 kuvame ukwenziwa ukuqapha impendulo yakho emitholampilo yomdlavuza webele . Uma amazinga akho ephakama, kungase kubonise ukuthi umdlavuza wakho ubuya noma uthuthuka, futhi kungadingeka ukuthi ulungise izindlela zakho zokwelapha ngokufanele. Uma amazinga akho ewa, kungase kubonise ukuthi ukwelashwa kwakho kuphumelela ukubulala umdlavuza wakho.
- Ukubheka ukuphindaphindiwe kokuqala-Uma ukwelashwa kwakho ngomdlavuza wesifu sekuqediwe, lokhu kuhlolwa kungenziwa ngezikhathi ezijwayelekile ukuthola ukuphindaphindiwe komdlavuza wakho. Ukuphakama kwe-CA 27.29 kwenzeka, ngokwesilinganiso, cishe izinyanga ezinhlanu ngaphambi kokuphindaphinda kubonakala ngokusekelwe ezinkomba noma ekucwaningweni kuphela. Naphezu kwalokhu, kusekhona impikiswano mayelana nokuthola noma ukuthola ukuphindaphinda komdlavuza ngaphambi kokuba izimpawu zenze umehluko ekwelapheni futhi, ekugcineni, umphumela wesifo.
- Ukuqapha umdlavuza we-metastatic (isheke lesimo) -Uhlolo luzosiza labo abanomdlavuza webele we-metastatic uma ngabe umdlavuza wabo uyaqhubeka. Lokho kusho ukuthi amazinga aphezulu angahlala isikhathi esithile futhi, ngesifundo esisodwa, amaphesenti angu-30 abantu ayenamazinga aphezulu aphikelela izinyanga ezimbili kuya kwezintathu ngemuva kokuqala ukwelashwa okuphumelelayo.
Lokhu kuhlola akunconywa njengendlela yokuhlola umdlavuza webele , noma njengendlela yokuthola umdlavuza webele wodwa, ngoba ayinakho lokho ososayensi abhekisela njengenani lokubikezela.
Ngaphezu kwalokho, odokotela bahluka ngokuphawulekayo emisebenzini yabo yokuhleleka lokhu kuhlolwa. Abanye odokotela bagcizelela ukuvivinya okuncane, kanti abanye bahlale beyihlela njalo.
Ukulinganiselwa
Kubalulekile ukuqaphela ukulinganiselwa kokuhlolwa kwe-CA 27.29. Ekuqapheliseni ukwelashwa komdlavuza webele we-metastatic-ukuthi lokhu kuhlolwa kuvame ukusetshenziswa kanjani-kubalulekile ukuphinde uqaphele ukuthi amazinga aphezulu we-CA 27.29 angaqhubeka kuze kube izinyanga ezintathu emva kokuba ukwelashwa kuqediwe.
Ngamanye amazwi, uma uvivinyo lwenziwe izinyanga ezimbalwa ngemuva kokuqeda ukwelashwa, amazinga angase aphakame ngisho noma uphendula kahle ukwelashwa.
Njengoba uhlolo lwe-CA 27.29 luwukuphela kokuhlolwa okusetshenziselwa ngokuqondile ukubona ukuthi kukhona amangqamuzana omdlavuza wesifuba, kubonakala sengathi kuzobekwa njalo ukuthi kuhlolwe umdlavuza webele.
Noma kunjalo, njengoba kuphawuliwe, lo mvivinyo awunakho ukubaluleka kokuqagela ekunqumeni ukuba khona komdlavuza wesifuba.
Inani elihle lokubikezela libhekisela ekutheni unesifo uma uhlola ukuthi unesifo esifanele. Kukhona izivivinyo eziningi emithi ezobonakala zinengqondo njengendlela yokuhlolisisa isifo, nokho ezifundweni, azikho ukunemba ukwenza umehluko ezindabeni zokusinda.
Umkhawulo wokugcina lapho ukuhlolwa kusetshenziselwa ukuthola ukuphindaphindiwe. Kukhona ingxoxo enkulu mayelana nokuthi ukuthoma ukuphindaphinda umdlavuza webele kungenza umehluko. Ngenkathi, ekuboneni kuqala, kubonakala sengathi kuzoba nenzuzo kulo mkhuba, ukuhlola akutholakalanga ukuthi izinga lokusinda lithuthuka uma ukuphindaphindiwe komdlavuza webele kutholakala kusenesikhathi.
Ingxenye yokudideka ikhona emigomweni yokwelapha isifo somdlavuza webele wesandulela-ngculazi ngokumelene nomdlavuza webele we-metastatic. Njengoba isifo somdlavuza webele sesisencane, umgomo uvame ukwelapha lesi sifo ngokucindezelayo ukuze ukwelaphe umdlavuza (noma okungenani ugcine ungabuyeli.) Nokho, ukwelashwa okufuthekayo akuyona umgomo womdlavuza webele we-metastatic (nakuba lokhu kungashintsha esikhathini esizayo esiseduze) njengoba kungabonakali okwenza umehluko kumazinga okusinda. Esikhundleni salokho, umgomo wukuthi ngokuvamile usebenzise okungenani ukwelashwa okuncane okungenzeka ukulawula lesi sifo.
Izingozi
Ukuhlolwa ukuhlolwa kwegazi okulula ngakho izingozi zincane. Izingozi ezingenzeka zingabandakanya ukukhathazeka okuhlobene nokuhlolwa okungavamile noma umphumela wokuhlola ongafanisi kahle isimo somdlavuza wakho.
Njengoba lokhu kuhlolwa kwenziwa kuphela njengengxenye yomdlavuza wokuqapha umonakalo, ingozi ngokuvamile ayinandaba kakhulu. I-CA 27.29 akuyona ukuhlolwa okuphelele, kodwa kuvame ukusiza kanye nezinye izivivinyo, ezifana nokucabanga, ukuhlola ukuphindaphinda nokuphendula kokwelashwa.
Izimbangela zezinga eliphakeme le-CA27.29 ezigulini ezingenalo isifo socansi
Ezinye zegciwane, kanye nezimo ezinobungozi, kungaholela ezingeni eliphakeme le-CA 27.29. Amanqamu angabangela umphumela ophakeme afaka:
- Umdlavuza we-Lung
- Umdlavuza wesibindi
- Umdlavuza we-Pancreatic
- Umdlavuza weColon
- Umdlavuza we-Ovarian
- Umdlavuza we-prostate
Izimo ezinobungozi ezingakhuphula i-CA 27.29 zibandakanya:
- Ama-cysts ama-ovari
- Izimo zesifuba se-Benign zesifuba nezinso
- Isifo sesibindi, njenge-cirrhosis-ekutadisheni okulodwa, kwabantu abaphakeme nge-CA 27.29 kodwa bengenayo umdlavuza, imbangela yayingu- cirrhosis amaphesenti angu-25 yesikhathi
Ngaphezu kwe-CA 27.29, kunezinye izimpawu zomzimba ezingasetshenziswa ukuhlola umdlavuza webele. Lokhu kufaka:
I-KI-67 ayisetshenziselwa ukuqapha umdlavuza webele.
Ngokuvamile, noma ukuhlolwa kwe-CA 27.29 noma ukuhlolwa kwe-CA 15-3 kuzokwaziswa, kodwa hhayi kokubili.
Izwi elivela
I-CA 27.29 ingasetshenziselwa izinhloso eziningana ezihlukene ngomdlavuza wesifuba futhi yiyona i-biomarker eyodwa esetshenziselwa ngokukhethekile ukucacisa ukuba khona kwamaseli omdlavuza webele. Lokho kusho ukuthi kunezinye ukwelapha kanye nezimo ezinobungozi ezingaholela emazingeni aphakeme.
Kubalulekile futhi ukuqonda ukulinganiselwa kokuhlolwa uma isetshenziselwa ukuhlola umdlavuza webele. Futhi ukuhlolwa kufanele kusetshenziswe ngaso sonke isikhathi ngokubambisana nezinye iziphumo, njengokuhlolwa ngokomzimba, ukuhlolwa kwegazi, nokuhlola izithombe.
Ngokufingqa, ukubaluleka kwalesi sivivinyo kwabesifazane abanomdlavuza wesifuba kungukuthi kunganikeza ngolwazi bese kukuqondisa nodokotela wakho ngokuthi:
- Impendulo yakho ekwelapheni
- Isimo somdlavuza wakho
- Kungenzeka ukuphindaphinda ngokushesha
> Imithombo
> Society of American of Clinical Oncology. Ama-Biomarker Ukuqondisa Ukwelashwa Kwe-Breast Metastatic Breast Cancer. Julayi 2015.
> Poznak, C., Somerfield, M., Bast, R. et al. Ukusetshenziswa kwama-Biomarkers Ukuqondisa Izinqumo Ngokuthwala Kwemvelo Kwabesifazane abane-Metastatic Breast Cancer: UmNyango we-American Society of Clinical Oncology Clinical Practice Guideline. I-Journal ye-Clinical Oncology . 2015. 33 (24): 2695-2704.