Kungakhathaliseki ukuthi wena noma othandekayo uthola ukwelashwa ngomdlavuza webele, kungokwemvelo ukugonywa nenani elikhulu lokuhlolwa okulethwe udokotela wakho.
Ukuhlolwa kwegazi elilodwa okungalawulwa uma unomdlavuza webele (noma unayo) ubizwa ngokuthi umdlavuza we-antigen 15-3 (CA 15-3) we-biomarker.
Ama-biomarker yizinto ezingaphakathi kwegazi lomuntu ezingasetshenziswa ukuqapha ukukhula komdlavuza-"ziphawula" ukuba khona komdlavuza.
Ukuhumusha i-CA 15-3 Ukuhlolwa Kwegazi Ngomdlavuza Webele
I-CA 15-3 iyiprotheni engumkhiqizo ojwayelekile wezicubu zakho zesifuba. Ngenkathi amaprotheni we-CA 15-3 engabangeli umdlavuza webele, uma isisu somdlavuza sisesiswini sakho, amazinga akho e-CA 15-3 anganda njengoba inani lamangqamuzana omdlavuza landa.
Lokhu kungenxa yokuthi amaseli we-tumor angaphala amakhophi we-protein ye-CA 15-3, engakalwa ngokuhlolwa kwegazi.
Ngenkathi ukuhlolwa kwegazi kwe-CA 15-3 kungasetshenziswanga ukuhlola noma ukuxilonga umdlavuza webele, kunezinye izizathu ezintathu zokuthi kungani udokotela wakho eyala lokhu kuhlolwa kwegazi:
Ukuhlola Ukuphindaphinda Ngomdlavuza Webele
Uma usuqedile ukwelashwa komdlavuza wesifuba, udokotela wakho angase avivinye igazi lakho nge-CA 15-3 ohlelweni olujwayelekile ukuze ubone ukuthi amazinga akho ayakhula noma ahlale azinzile. Amazinga akhuphuka we-CA 15-3 angabonisa ukuphindaphinda komdlavuza webele . Njengoba ezinye izimo zingabangela amazinga aphezulu we-CA 15-3, noma kunjalo, imiphumela yokuhlolwa kufanele icatshangwe kanye nemiphumela yezifundo zokucabanga, izimpawu zakho, nezinye izivivinyo.
Ukuqapha Indlela Ophendula Ngayo Ukwelashwa Kwebelevuza Isisu
Amazinga alandelayo we-CA 15-3 angasiza udokotela wakho ukuthi ngabe ukwelashwa kwakho kusebenza noma cha. Kubalulekile ukuqaphela, noma kunjalo, ukuthi kungathatha amasonto amane kuya ayisithupha emva kokwelashwa ngaphambi kokuba ushintsho lubonwe ezingeni le-CA 15-3.
Okungafani nalokhu, okubalulekile ukuphawula, kulabo besifazane abaphathwa nge-chemotherapy drug Afinitor (everolimus).
Ngenxa yokuthi le mithi isebenza ngokumelene nomdlavuza webele, imiphumela ye-CA 15-3 yokuhlolwa kwemvelo ingase ihluke okwenzekayo ngomdlavuza wakho. Ngamanye amazwi, noma ngabe umdlavuza wakho uphendule ku-Affinitor, izinga lakho le-CA 15-3 lingase likhuphuke, futhi uma umdlavuza wakho uqhubeka nokuqhubeka, izinga lakho le-CA 15-3 lingase lihlehlele, linikeze umbono weqiniso wokuthi isifo sakho sithuthuka.
Ukunquma Uma I-Cancer Yakho Iqhubekile
Uma izinga lakho le-CA 15-3 liqhubeka landa, kungase kusiphakamise ukuthi umdlavuza wakho uyanda. Eqinisweni, izinga le-CA 15-3 lixhunyaniswa nesilinganiso sokusakazeka komdlavuza wesifuba futhi kuvame ukuphakama ikakhulukazi lapho ama- metastase we-bone kanye / noma i- metastases yesibindi ekhona (imithi yesigciwane isho ukuthi umdlavuza webele usakaze kwezinye izitho ngaphakathi umzimba).
Amapulangwe we-CA 15-3 Ukuhlolwa Kwegazi
Njengoba kukhonjisiwe, amazinga e-CA 15-3 avame ukuphakama ikakhulukazi kwabesifazane abane-metastase yesibindi noma yethambo ngenxa yomdlavuza wesifuba, yingakho ukuhlolwa kwe-CA 15-3 kwe-tumor marker kuyasiza kakhulu ekuqapheliseni impendulo kumuthi we-cancer wesifuba we-metastatic .
Noma kunjalo, kunezigcawu ezimbalwa okufanele uzikhumbule lapho uhumusha imiphumela yakho:
Akuyona yonke i-Tumor Tumor Causes Isuka ku-CA 15-3
Kulaba besifazane abanezicubu zebele ezithwala i-CA 15-3 noma ngezibeletho zesifuba sokuqala, lesi sivivinyo asiwusizo.
Eqinisweni, ngamaphesenti angu-30 kuphela abesifazane abanomdlavuza webele wendawo (okusho ukuthi umdlavuza ulinganiselwe esifubeni) uzoba namazinga akhuphule we-CA 15-3. Ngakolunye uhlangothi, kubesifazane abanomdlavuza wesifuba we-metastatic, i-CA 15-3 ingatholakala Amaphesenti angu-50 kuya kwangu-90 azo zonke izimo.
Ezinye izimo zingase zenze i-CA ephakanyisiwe 15-3
Uma ukuhlolwa kwegazi kwe-CA 15-3 kuphakanyisiwe, akusho ukuthi unomdlavuza wesifuba we-metastatic noma ngisho nomdlavuza webele. Lokhu kungenxa yokuthi kunezinye izimo eziningana ezingabangela izinga eliphakeme le-CA 15-3 njengo:
- Amanye amagciwane, kuhlanganise nomdlavuza wesibeletho, umdlavuza wamaphaphu , umdlavuza we-pancreatic, umdlavuza wesibindi, umdlavuza wesifo sofuba, nomdlavuza we-colon
- I-cirrhosis yesibindi
- Isifo sofuba
- Izimo zesifuba zaseBenign
- Ukubeletha
- Ukukhulelwa
- Lupus
- Isifo sokuvuvukala sama-pelvic
- I-Endometriosis
- I-Sarcoidosis
I-CA 15-3 Imiphumela Ayinkulu Ekubikezelweni Kwe-Prognosis
Ngenkathi ukuhlolwa kwegazi kwe-CA 15-3 kuvame ukuphakama ngokusabalala kwe-cancer yemfu ye-metastatic, akuzona ngaso sonke isikhathi okuhle kakhulu ekulinganiseni ukubikezelwa kwakho (ithuba lakho lokubuyisela emdlalweni webelevuza).
Ngamanye amazwi, ngenkathi ukuhlolwa kwegazi kwe-CA 15-3 kunganikela ngolwazi oluwusizo, alusetshenziselwa ukuqondisa ukwelapha umdlavuza wakho webele kuphela noma ukuqapha ukuthi uphendula kanjani kahle ukwelashwa kwakho kwamanje.
Izwi elivela
Uma izinga lakho le-CA 15-3 le-tumor marker liphakanyisiwe, futhi likholelwa ukuthi lihlobene nokusakazeka komdlavuza webele, wena nodokotela wakho uzobukeka ezinye izici eziningi ekwenzeni izinqumo mayelana nokuhlolwa okuqhubekayo kanye nokwelashwa.
Ezinye zalezi zici zifaka ubukhulu besisu sakho, ezinye izivivinyo zokumangalisa, imiphumela yezifundo zokucabanga, kanye nanoma yikuphi okutholakele emlandweni wakho noma ukuhlolwa komzimba.
Okubalulekile lapha ukuthi ukuhlolwa kwegazi kwe-CA 15-3 kuyisici esisodwa se-puzzle uma kuziwa kuwe noma umdlavuza wakho webele. Kunezici eziningi ezingena ekunqumeni isinyathelo esilandelayo, futhi ukubikezela kwakho kuhamba ngaphezu kwamanani webhu. Ngokuyinhloko, ukuhlolwa kwegazi le-CA 15-3 kungaholela ekukhathazeni njengoba kungathatha amasonto ayisithupha ukuwa phansi ngemuva kokwelashwa okuphumelelayo, futhi ngezinhlobo ezithile zokwelashwa, izinga lingashintsha ngempela ekuqondeni okusho okuphambene nalokho okuyiyo okwenzeka ngempela.
Okokugcina, enye yezinto ezibaluleke kakhulu ongayenza njengomuntu osindile umdlavuza webele kufanele abe ummeli wakho ekunakekelweni komdlavuza wakho . Ekufundeni ngamakhamera we-tumor afana ne-CA 15-3, uthathe isinyathelo esibaluleke kakhulu ukwenza kanjalo.
> Imithombo:
> Fejzic, H., Mujagic, S., Azabagic, S., noMnu Burina. I-tumor marker CA 15-3 ezigulini zomdlavuza webele. I-Acta Medica Academica . 2015. 44 (1): 39-46.
> Nieder, C., Dalhaug, A., Haukland, E., Mannsaker, B., no A. Pawinski. Umphumela wokubikezela we-Marker Tumor CA 15-3 ezigulini ezine-Cancer Breast and Bone Metastases ezithathwa nge-Palliative Radiotherapy. I-Journal of Clinical Medicine Research . 2017. 9 (3): 183-187.
> Rafey, M., Akhtar, K., Rab, A. et al. I-Serum Ca 15-3: Isimpawu Esibalulekile Sokukhwabanisa Ku-Prognostication of Cancer Advanced Breast Cancer. Amanothi Wezempilo Yomama Nezingane . 2017. 3 (4): A50-A51.
> Shao, Y., Zianfu, S., Yaning, H., Chaojun, L., no H. Liu. Amazinga aphakanyisiwe Amakhamera we-Serum Tumor Tumor CEA ne-CA15-3 yiziParagratic Parameters ze-Molecular Subtypes ezahlukene ze-Cancer Breast. PLoS One . 2015. 10 (7): e0133830.