Ukusebenza Kanjani, Imiphumela Eceleni, nokuningi
I-Gabapentin iyisidakamizwa esivame ukushiwo i- fibromyalgia . Itholakala njenge-generic futhi ibuye ithengiswe ngaphansi kwegama lamagama we-Neurontin, Horizant, no-Gralise.
I-Gabapentin ayiyona i-FDA evunyelwe ukuphatha lesi simo, ngakho-ke inqunyiwe-ilebula. Lesi sidakamizwa sihlobene nemikhiqizo ehlobene neLyrica (pregabalin) , esivunyelwe njengokwelashwa kwe-fibromyalgia.
Eqinisweni, ngezinye izikhathi iLyrica ibizwa ngokuthi "indodana kaNeurontin."
I-Gabapentin ihlukaniswa njengesidakamizwa sokulwa nokuthunjwa. Isetshenziselwa ukwelapha isifo sofuba, i-neuropathy (ubuhlungu obuvela emithanjeni ewonakele), imilenze yokuphumula yemilenze , nokukhanya okushisayo.
Ubuhlungu be-Fibromyalgia bufana ne-neuropathy, kodwa ngabe lesi simo sihilela ukulimala kwesibindi namanje akucaci.
Indlela iGabapentin Isebenza ngayo
I-Gabapentin ikholelwa ukuthi isebenza ngokushintsha ukukhululwa kwe- glutamate namanye ama-neurotransmitter ebuchosheni bakho. Ama-neurotransmitters athumela imilayezo esuka kwesinye isisindo sengqondo kuya kwesinye.
I-Glutamate iyasiza kakhulu ezintweni ezithile, njengokufunda ulwazi olusha. Kungenxa yokuthi ithola amangqamuzana akho obuchopho avuselele futhi asebenze.
Uhlobo olunjengezingane ezincane nge-tshokolethi, noma kunjalo, uma une-glutamate eningi kakhulu egijima laphaya, amangqamuzana akho obuchopho angaphumelela. Lokho kungenza zonke izinhlobo zezinto zihambe kahle.
I-glutamate inomsebenzi ongaphezu kweyodwa, noma kunjalo.
Kubuye kusize ukudlulisela izimpawu zobuhlungu ebuchosheni nasezintweni zakho. I-glutamate eningi kakhulu ingadlala indima ku- hyperalgesia , okuyisisekelo sokuguqula ivolumu yobuhlungu.
Ukuvikela imiphumela ye-glutamate, une-neurotransmitter ebizwa nge- gamma-aminobutyric acid (GABA) . Ithobisa amangqamuzana akho futhi iduduza ubuchopho bakho.
Uma i-GABA ne-glutamate ikhona ngokulinganisela komunye nomunye, izinto zihamba kahle.
Ezinye izifo nezimo zingase ziphazamise lokhu kubhaliswa futhi uvumele i-glutamate isebenze i-amok. I-Gabapentin ikholelwa ukuthi inciphisa ukukhululwa kwengqondo yakho kwe-glutamate ngakho amaseli angakwazi ukuzola futhi ubuchopho bakho bungasebenza kangcono.
I-Gabapentin ye-Fibromyalgia
Ucwaningo lubonisa ukuthi abantu abane-fibromyalgia bane-glutamate kakhulu kakhulu ezingxenyeni ezithile zobuchopho babo, ngakho-ke i-gabapentin iye yabekwa isikhathi eside.
Kodwa ingabe iphumelela? Ucwaningo luhlanganisiwe.
Ukubuyekezwa okubili kobufakazi abuvumelani. Omunye okhululwe ngo-2016 wathola ukuthi i-gabapentin iyindlela yokwelapha ephumelelayo ye-fibromyalgia, kodwa enye, eyanyatheliswa ngo-2017, ibike ubufakazi obuphansi kuphela.
Ukubuyekezwa kuka-2014 kwe-gabapentin ye-fibromyalgia ne-neuropathy ithola ukuthi cishe amaphesenti angu-35 abahlanganyeli bezobucayi babona ubuhlungu babo behla ngamaphesenti angama-50 ngenkathi kulesi sidakamizwa. Kubalulekile ukuthi uqaphele ukuthi amaphesenti angu-21 abone amaconsi afanayo lapho ethatha indawo ye-placebo.
Ucwaningo oluqhathanisa i-gabapentin ne-pregabalin (isidakamizwa eLyrica), kufaka phakathi eyodwa eshicilelwe kuyi -Journal of the American Medical Association, i- pregabalin yabonakala yenza ngcono.
Ifomu elikhululiwe lokukhishwa kwe-gabapentin lithembisa isithembiso esilweni esisodwa esincane eshicilelwe ku- Practice Pain .
Abacwaningi bathi kuthuthukiswa ubuhlungu, ukulala, kanye nekhwalithi yokuphila. Lokhu kwakuyisivivinyo sokuqala, noma kunjalo, umsebenzi omningi kufanele wenziwe ngaphambi kokuba siqiniseke ukuthi ngabe isikhathi eside siphephile futhi sisebenza kahle.
Isilinganiso se-Gabapentin
I-Gabapentin ivame ukuqala ngomthamo ophansi bese kancane kancane yanda. Qinisekisa ukulandela imiyalelo kadokotela wakho.
Izinga elijwayelekile phakathi kuka-900 mg no-1,800 mg nsuku zonke, lihlukaniswe ngamanani amathathu.
Akufanele uyeke ukuthatha gabapentin ngokuzumayo. Qinisekisa ukuthi ukhuluma nodokotela wakho mayelana nenqubo yokuhlanza efanele yokwenza umthamo osithathayo.
I-Gabapentin Side Effects
Njengazo zonke izidakamizwa, i-gabapentin ihamba nengozi yemiphumela emibi.
Ezinye zingase zibe yingozi ngenkathi ezinye zingekho.
Uma unemiphumela emibi elandelayo ngenkathi uthatha i-gabapentin, shayela udokotela wakho ngokushesha:
- ubuthakathaka obukhulu bokukhathala
- ubuhlungu besisu esisenhla
- ubuhlungu besifuba
- ukukhwehlela okusha noma okuqhubekayo kanye nomkhuhlane
- ubunzima bokuphefumula
- ukugubha okukhulu noma ukunganaki
- ukunyakaza kwamehlo okusheshayo, okuphindaphindiwe nokuphuma
- ubuhlungu noma ubunzima bokuvuthwa, noma akukho ukuchama
- umkhuhlane
- Umphimbo obuhlungu
- ukuvuvukala ebusweni noma ngolimi
- amehlo ashisa
- ukushayeka
Imiphumela emibi engeyona imbangela yokukhathazeka okusheshayo ihlanganisa:
- ukukhathala
- isiyezi
- ikhanda
- balele belele
- inzuzo yesisindo
Izingane ezithatha i-gabapentin zingase zithole i-side effects yemiphumela emibi. Xhumana nodokotela wakho ngokushesha kulokhu okulandelayo:
- izinguquko ekuziphatheni
- izinkinga zememori
- ukungakwazi ukugxila
- ukuphumula, ubutha, noma ukuhlukunyezwa
I-Gabapentin ingase isabele kabi kabi nezinye izidakamizwa. Qinisekisa ukuthi udokotela wakho kanye nekhemisi bayazi konke ozithathayo.
Ingabe i-Gabapentin Ikulungele Wena?
Njengoba ubufakazi bubuthakathaka futhi buxubene, i-gabapentin inenzuzo eyodwa ngaphezu kweLyrica-iyinto ejwayelekile, ngakho-ke iyabiza kakhulu. Ukuhluka kwentengo kubangela abanye abantu ukuba bazame i-gabapentin naphezu kokubonisa okubuthakathaka kwizifundo.
Futhi, sonke senza ngokuhlukile imithi. Abanye abantu abahluleka kwezinye izidakamizwa bangathola ukukhululwa ku-gabapentin.
Uma unesithakazelo ekuzameni i-gabapentin, khuluma nodokotela wakho mayelana nenzuzo nokuqeda komuthi kanye nokuthi ungangena kanjani emgodini wakho wokulashwa jikelele.
> Imithombo:
> I-Calandre EP, i-Rico-Villademoros F, i-Slim M. Apha2delta ligands gabapentin, i-pregabalin ne-mirogabalin: ukubuyekezwa kwemithi yabo yezokwelapha kanye nokusetshenziswa kwezokwelapha. Ukubuyekezwa kochwepheshe we-neurotherapeutics. 2016 Nov; 16 (11): 1263-1277.
> Cooper TE, uDerry S, Wiffen PJ, Moore RA. I-Gabapentin yezinhlungu ze-fibromyalgia kubantu abadala. Idatha yeCochrane yokubuyekeza okuhlelekile. 2017 Jan 3; 1: CD012188.
> Moore RA, Wiffen PJ, uDerry S, et al. I-Gabapentin yezinhlungu ezingapheli ze-neuropathic kanye ne-fibromyalgia kubantu abadala. Idatha yeCochrane yokubuyekeza okuhlelekile. 2014 Apr 27; (4): CD007938.
> Moore A, Wiffen P, Kalso E. Izidakamizwa ze-Antiepileptic zezinhlungu ze-neuropathic kanye ne-fibromyalgia. I-JAMA. 2014 Jul; 312 (2): 182-3.
> North JM, Hong KS, Rauck RL. Umphumela wenqubo yombhalo we-release-release gabapentin ebuhlungu kanye nokulala ezifundweni ze-fibromyalgia: isifundo sokuhlola umshayeli ovulekile. Ukusebenzisa ubuhlungu. 2016 Jul; 16 (6): 720-9.