Yimiphi imisebenzi abayenzayo, yiziphi izinkinga ezingabangela
I-GABA kanye ne-glutamate yizinzwa ze- neurotransmitters- izithunywa ezinomqondo ebuchosheni bakho. Enye iyathulisa, enye iyavuselela, futhi kufanele ihlale ibhalansi nomunye nomunye. Ngakho kwenzekani uma lesi sikali siphonswa?
Olunye ucwaningo lubonisa ukungalingani kwalezi zinto ezimbili zingadlala indima e- fibromyalgia (i-FMS). Ukucwaninga akunamandla ekubandakanyekeni kwabo ekudleni okungapheli (i- ME / CFS ), ngezifundo ezithile zifakazela ubufakazi bokuhlukumezeka nabanye abatholi lutho.
Ubuningi Bakho
Ubuchopho bomuntu bunzima kakhulu. I-neurotransmitter ngayinye yenza imisebenzi ehlukahlukene, futhi ixhumana nomunye nomunye ne-neurons yakho (amangqamuzana ebuchopho) ngendlela enzima esingayiqondi ngokugcwele.
Noma kunjalo, silokhu sifunda kabanzi mayelana nobuchopho nabacwaningi baye bakwazi ukuxhumanisa ezinye izinto ezingavamile zezinkinga ezithile eziguleni noma izimpawu ezithile. Baye bathola izindlela zokushintsha umsebenzi we-neurotransmitter futhi bangabona imiphumela yangempela enayo kwizihloko zocwaningo.
Ubuchopho buyindlela evuselelayo yokuvuselela, ngokuvamile besebenzisa i-neurotransmitter eyodwa ukudala enye. Lo msebenzi wenza umqondo omkhulu lapho ukhuluma ngama-neurotransmitter nemisebenzi ehlukile, njenge-GABA ne-glutamate. I- serotonin eyaziwa kangcono ne- melatonin pair isinye isibonelo, njenge-norepinephrine ne-dopamine. Konke kulawo ma-neurotransmitters akholelwa ukuthi ahlukaniswe kulezi zimo.
Uma i-neurotransmitter eyodwa ebhodini ingekho ibhalansi, ingase iphonse enye ibhalansi, futhi.
I-Glutamate
I-glutamate inhlobo ye-cheerleader yobuchopho bakho. Enye yemisebenzi yayo eyinhloko ukuthola amanye amangqamuzana obuchopho asusiwe. Kubakhuthaza ukuze bakwazi ukwenza izinto ezibalulekile njengokufunda ulwazi olusha noma ukwakha izinkumbulo-ezinye izinto lapho kuhlanganiswa khona i-glutamate.
Kodwa-ke, i-cheerleader engalokothi iphele ukwenza ukuthi uphethe izinto iyacasula ngemuva kwesikhashana. Okuncane kakhulu okukhuthazayo akuyona into enhle, njengoba noma ubani ophuzile ikhofi kakhulu angakutshela. Ezimweni ezithile, i-glutamate ingaba yinto ebizwa ngokuthi "i-excitotoxin," okusho ukuthi ngezinye izikhathi kubonakala sengathi ihamba phambili-ivuselela ama-neurons baze bazibulale.
Ikhono lokubangela ukufa kwezingqamuzana zobuchopho yingakho i-glutamate ikholelwa ukuthi ihileleke kwezinye izifo zobuchopho ezisabekayo ezifana nesifo se-Alzheimer kanye ne- amyotrophic lateral sclerosis (i-ALS noma isifo sikaLou Gehrig.) (Qaphela: i-FMS ne-ME / CFS ayikholelwa ukuthi kube yisisindo.)
Ku-FMS, ucwaningo lubonisa amazinga aphezulu kakhulu e-glutamate engxenyeni yobuchopho okuthiwa i-insula noma i-cortex e-insular. Abacwaningi baqala ukubuka lapho ngoba leyo ndawo ihilelekile kakhulu ebuhlungu nasezimpikweni, okuyizinto eziyinhloko zesimo. I-insula nayo ihileleke ekuboneni okuqondayo, amakhono emoto, ukukhathazeka, ukuphazamiseka kokudla, nokulutha umlutha.
Ucwaningo luye lwaluhlanganisa amazinga aphezulu e-glutamate nokucindezeleka kanye nomsebenzi ophansi wokuqaphela abantu abanesifo sikashukela sohlobo 1. (I-Glutamate ingathathwa ku-glucose, ngokuvamile ephezulu kubantu abanesifo sikashukela.) Okungenani isifundo esisodwa se-FMS sisiphakamisile ukuthi ukwehlisa amazinga e-glutamate kunganciphisa ubuhlungu.
I-glutamate yobuchopho obuningi ikholelwa ukuthi ibangela izimpawu eziningi, kufaka phakathi:
- i-hyperalgesia (ubuhlungu bokukhulisa, isici esiyinhloko se-FMS)
- ukukhathazeka
- ukuphumula
- Izimpawu ezifana ne-ADHD, njengokungakwazi ukugxila
KuMe / CFS, abanye abacwaningi bacabanga ukuthi umsebenzi we-glutamate uphansi, okusho ukuthi ubuchopho abuzukukhuthazwa ngokwanele. Noma kunjalo, le nkolelo ayisekelwa ubufakazi.
Ukuntuleka kwe-glutamate ebuchosheni bakholelwa ukuthi kubangela izimpawu ezifaka:
- ukulala
- izinkinga zokuhlushwa
- ukukhathala kwengqondo
- amandla aphansi
IGABA
IGABA imele i-gamma-amino-n-butyric acid. Ubuchopho bakho busebenzisa glutamate ukukhiqiza iGABA.
Umsebenzi oyinhloko we-GABA ukuphucula ubuchopho bakho.
Kubuye kuhileleke ekulaleni, ekuphumuzeni, emithethweni yokukhathazeka kanye nemisipha yomsebenzi.
I-GABA ikholelwa ukuthi iphansi noma ayisebenzisi ngendlela engafanele ku-FMS. Kuze kube manje, ukucwaninga akusho ukuthi i-GABA ishicilelwe ku-ME / CFS.
Ngenxa ye-GABA nobuhlobo obuseduze, izibonakaliso zobuchopho i-GABA intukuthelo ingase ifane, noma ihlangane nayo, yocwaningo lwe-glutamate ngokweqile.
Ukuthola Ukulinganisela
Uma usola uGABA / glutamate dysregulation kubangela ezinye izimpawu zakho, khuluma nodokotela wakho ngakho. Kunezidakamizwa, izithako, nezinguquko zokudla ezingakusiza ukuthi uthole ibhalansi efanele. Ungahlola lezo zindlela lapha:
Imithombo:
UHannestad U, Theodorsson E, Evengård B. Iphephabhuku lamazwe omhlaba wemithi yamakhemikhali. 2007 Feb; 376 (1-2): 23-9. Epub 2006 Jul 14. i-beta-Alanine ne-gamma-aminobutyric acid e-syndrome engapheliyo yokukhathala.
I-Harris RE, et. al. I-arthritis ne-rheumatism. 2009 Okthoba; 60 (10): 3146-52. Ukuphakama kwe-glutamate e-fibromyalgia kuhlotshaniswa nobuhlungu bokuhlola.
I-Harris RE, et. al. I-arthritis ne-rheumatism. 2008 Mar; 58 (3): 903-7. Amazinga anamandla we-glutamate ngaphakathi kwe-insula ahlobene nokuthuthukiswa kwezizinda eziningi zobuhlungu ku-fibromyalgia.
> Lyoo IK, et. al. Izigcinwa zezinkinga zokugula ngengqondo. 2009 Aug; 66 (8): 878-87. Amazinga ase-prefrontal glutamate-glutamine-gamma-aminobutyric acid futhi ahlobene nokusebenza okuphansi kwengqondo kanye nezimpawu zokucindezeleka kuhlobo lwe-1 lwesifo sikashukela.
I-Murrough JW, et. al. I-NMR ku-biomedicine. 2010 Jul; 23 (6): 643-50. I-lactate ye-ventricular ekhulayo e-syndrome engapheliyo yokukhathala ilinganiselwa ku-1H imaging ye-MRS ku-3.0 T. II: ukuqhathaniswa nengcindezi enkulu yokucindezeleka.