Ingabe Kukhona Ukuxhumana Phakathi Kokukhubazeka kwe-AD ne-Your Sense of Smell?
Yuck! Kuyini lokho kunuka? Ngokusho kwabanye abacwaningi, ikhono lakho lokuphendula lo mbuzo lingase libikezele amathuba akho okuthuthukisa isifo se-Alzheimer .
Ucwaningo oluningi lweminyaka engamashumi amabili edlule lubonise ukuxhumana phakathi kokuhluleka ukuthola iphunga nokunciphisa ukuqonda. Eminye yalezo zifundo nazo zabonisa ubuhlobo obubikezelayo lapho umuzwa omubi wokuzwa iphunga kubantu abangenayo ukuwohloka komqondo wabikezela amathuba okwanda kwalabo bantu abanjalo abathuthukisa izifo zesifo se-Alzheimer ngokuhamba kwesikhathi.
Isibonelo, isifundo esisodwa esibandakanya abantu abangaba ngu-3 000 abaneminyaka engama-57 kuya ku-85 abanokuqashelwa okujwayelekile abaye bafundiswa eminyakeni emihlanu. Abacwaningi bathola ukuthi ukwehlisa ikhono lokutshela umehluko phakathi kwephunga kwakuhlotshaniswa kakhulu nokuphindwe kabili ingozi yokuhlaziya umqondo.
Abacwaningi babuye babheka ukukhubazeka okuncane okungaqondakali . Ukukhubazeka okungacabangi komqondo kuyisimo lapho abantu banenkinga ethile ngemisebenzi yokukhumbula , ukuhlushwa, ukucabanga, kanye nokuxhumana njengamakhono okuthola amagama . Ezinye, kodwa hhayi zonke, izimo zokukhubazeka okungenangqondo okuqhubekayo zibe sesifo se-Alzheimer's.
Esicwaningweni seminyaka emihlanu, ososayensi bahola abantu abangu-589 abahlala emakhaya abo. Akekho wabahlanganyeli ababenokukhubazeka okunengqondo ekuqaleni kokucwaninga. Ukusebenza komuntu ngamunye nokukwazi ukuthola iphunga kwavivinywa ekuqaleni kokutadisha, futhi ngonyaka emva kwalokho.
Imiphumela? Abahlanganyeli ababonise ubunzima ekutholeni iphunga babhekene nokunciphisa izikolo ekuhlolweni kokusebenza kokuqonda. Ngamanye amazwi, ukungakwazi ukukhomba iphunga elibikezelwe ukuthi ngubani ozoqala izibonakaliso zokukhubazeka okungenangqondo.
Ezinye izifundo ziye zathola ukuthi ukusebenza okungalungile okubikezelayo kwabikezela ukuwohloka kwesikhathi esizayo emasikweni e- MMSE nokuthi ikhono elikhulu lokubona iphunga lalihlotshaniswa kahle nenkumbulo esheshayo nokulibaziseka, ukuzwakala komlomo , ikhono lokubona i-visuospatial , kanye nekhono lokuqonda.
Yini Ebangelwa Ukuthi Inkohliso Kufanele Yithinteke Eziguleni Zase-Alzheimer?
Yini ebangela ukulahlekelwa lokhu? Ucwaningo lubonisa ukuthi umuzwa wokuhogela uthinteka ukutholakala kwamaprotheni e- beta amyloid ezindaweni ezibuchopho ezisisiza ukuba sibone futhi sibone iphunga. Olunye ucwaningo lubonisa ukuthi lezi zindawo zobuchopho ziphi lapho amaprotheni aqoqa khona kuqala, okonakalisa umuzwa wokuhogela ngaphambi kokusebenza kwengqondo kuthinteka.
Ucwaningo oluningi luye lwabonisa ukulingana okuphezulu phakathi kwesifo se-Alzheimer kanye nesakhi samaprotheni okusebenza emzimbeni we-olfactory (umqondo wethu wephunga).
Ucwaningo olulodwa lubuyekeze imiphumela yama-autopsies angu-130 futhi lwathola ukuthi kuzo zonke izimo zesifo esiqinisekisiwe se-Alzheimer, kwakune-tau pathology ohlelweni lwe-olfactory lobuchopho.
Ucwaningo lwesibili olwenziwe ucwaningo lwathola ukuthi ekubukezeni ama-autopsies angu-273, kwakukhona ukulingana okuphezulu phakathi kwe-buildup of tau ohlelweni oluthile kanye nokulimala komqondo okuhlobene nesifo se-Alzheimer's.
Ucwaningo lubonisa ukuthi njengoba isifo se-Alzheimer siqhubeka, ikhono lokunuka liyehla.
Ingabe Ukulahlekelwa Kokuphunga Kuthuthukiswa Ngenye Inhlobo Ye-Dementia?
Abacwaningi bathole ukuthi kokubili isifo se-Alzheimer kanye no- Lewy ukucindezeleka komzimba kubonisa imiphumela ephawulekayo ngomqondo wokuhogela, kuyilapho abantu abanezinkinga eziqhubekayo zokuphefumula kwe-supranuclear ne- corticobasal bengabonisi ukukhubazeka.
Ingabe Ukuguga Kungaba Isizathu Sokuthi Inkohlakalo Iyancipha?
Naphezu kokuphazamiseka kobufakazi obonakala bukhona, i-athikili eyodwa yocwaningo iphakamisa imibuzo. Kulolu cwaningo, ososayensi bahlola izifundo eziningi eziye zaqhutshwa ngomqondo wokuhogela kanye nokubopha kwayo ekunciphiseni kokusebenza kwengqondo futhi iphetha ukuthi ucwaningo oluningi aluphumelelanga ukubonisa ubufakazi obuqinile ngenxa yokwakhiwa kwezifundo. Enye yezinto ezikhathazayo ukuthi njengoba abantu bekhula, umuzwa wokunuka kwephunga. Ngakho-ke, ucwaningo lufanele lucabangele lokhu kuhlolisisa ukuze ucwaningo lubonise ukuthi ukungakwazi ukukhomba iphunga akubangelwa iminyaka yobudala kodwa kunalokho inqubo ebuchosheni ehlobene nokulahlekelwa ukusebenza komqondo.
Ngokususelwa ekutheni inani eliphakeme locwaningo olwenziwe, noma kunjalo, kusenokwenzeka ukuthi kunomngcele phakathi komqondo omncane wokungcola nokuncipha kwengqondo.
Ingabe Kufanele Uvivinye Inkolelo Yakho Yokubhema Ukuze Uthole Uma Usemngciphekweni We-Dementia?
Ukuhlolwa okunephunga okulula akunconywa njengendlela yokubona labo abasengozini yokudemeka kwengqondo ngalesi sikhathi, nakuba kungenzeka ukuthi ingafakwa njengengxenye yebhethri yokuhlolwa. Okungaba ngcono kakhulu ngalesi sikhathi kugxile kulokho ongakwenza ukuze unciphise ingozi yokuthuthukisa u-dementia, njengokusebenza kwengqondo , ukuzivocavoca umzimba nokudla okunempilo.
Izwi kusuka
Uma ukhathazekile ngememori yakho futhi ubona ukuncipha kokwazi kwakho ukuthola noma ukukhetha iphunga, ungathatha ukuhlolwa kwekhaya njengesivivinyo sokuhlolwa kwesifo sengqondo se-SAGE . Qinisekisa ukuthi uhlela i-aphoyintimenti yokuxoxa ngemiphumela yakho nodokotela, ngoba kunezimbangela eziningana zokuguqulwa kwememori, kanye nezinzuzo eziningi ekutholeni ukushada komqondo kwangaphambili .
Imithombo:
I-Archives of General Psychiatry. 2007; 64 (7): 802-808. Ukukhomba Okucacile Nengqondo Yokukhubazeka Okuncane Okubucayi Eminyakeni Ebudala.
> Goette, W., Werry, A. noSchmitt, A. (2017). Ubudlelwane Phakathi Kwalabo Abakwa-Smell Identification kanye Ne Domains Neuropsychological: Imiphumela Evela Esikhathini Sabantu Abahlala Emphakathini Abasolwa Nge-Dementia. Journal of Neuropsychology Clinic and Experimental , pp.1-11.
I-Laryngoscope. Umqulu 122, Issue 7, amakhasi 1455-1465, ngoJulayi 2012. Ukuhlolwa Okubheka Ngokucacile njenge-Predictor of the Development of Dementia's Alzheimer's: Ukubuyekeza Okuhlelekile. http://onlinelibrary.wiley.com/doi/10.1002/lary.23365/abstract.
I-National Institute yokuguga. Izinyathelo Ekutholeni Izifo Zama-Alzheimer. http://www.nia.nih.gov/alzheimers/publication/2011-2012-alzheimers-disease-progress-report/advances-detecting-alzheimers#.UnJOohAhGoY
> Reijs, B., Ramakers, I. Elias-Sonnenschein, L., Teunissen, C., Koel-Simmelink, et al (2017). Ukuxhunyaniswa kobunzima be-Odor Identification nama-Alzheimer's's Markers in Cerebrospinal Fluid and Cognition. Journal of the Alzheimer's , 60 (3), pp.1025-1034.
> Tonacci, A., Bruno, R., Ghiadoni, L., Pratali, L., Berardi, N., et al (2017). Ukuhlolwa Okucacile Ngokwehluleka Kokuqonda Okuncane: Ukulungiswa Ngomsebenzi Neurocognitive and Endothelial Function. I-European Journal ye-Neuroscience , 45 (10), iphe.1279-1288.
Psychiatry yokuhumusha. 2012 Meyi, 2 (5), e118. Ukubandlulula Okucacile Kubikezela Ukuncipha Kwezinkinga Phakathi Kwabantu Abadala Abahlala Emphakathini. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365262/.