Ucwaningo luhlola ukuxhumana okungenzeka kunokwenzeka phakathi kwe-celiac, ukuzwela kwe-gluten nokumiswa kwengqondo
Nakuba abantu abaningi bacabanga ukuthi isifo se-celiac kanye ne-non-celiac gluten ukuzwela kube yizimo ezibandakanya kakhulu izinhlelo zabo zokugaya, ucwaningo lubonisa ukuthi lezi zimo empeleni zingase zibe nemiphumela evulekile emzimbeni wakho, kuhlanganise namalungu akho, ama-hormone akho, ngisho nobuchopho bakho.
Njengoba kunikezwe lokho, ingabe bangakwazi ukufaka isandla-noma ngisho nokubangela- isifo se-Alzheimer kanye nokuwohloka komqondo ?
Ngenhlanhla, kubonakala sengathi akunakwenzeka: ubufakazi obuvela ezifundweni zezokwelapha kuze kube manje uthi ukungenisa kwe-gluten akuphakamisi ingozi yokugula komqondo noma isifo se-Alzheimer uma unesifo se-celiac noma uzwela lwe-gluten.
Izifo ze-Celiac kanye nezifo ze-Alzheimer: Kuyini Ubufakazi?
UDkt. Alessio Fasano, oyinhloko yeSikhungo SeMassachusetts General Hospital sikaCeliac Research and Treatment, utshela ukuthi ukucwaninga kwakamuva, okwenziwe eSweden, kubonisa ukuthi ukuba nesifo se-celiac akukwandisi ingozi yokugula kwesifo sengqondo kanye ne-Alzheimer's disease.
Ucwaningo lwabheka abantu abangaba ngu-8 846 abaneminyaka engama-50 nangaphezulu abangatholakala ukuthi banesifo se-celiac besebenzisa i-biopsy yamathumbu ukuqinisekisa ukulimala kwamathumbu emathunjini, futhi wabalinganisa nabantu abangu-43 474 abangenayo isifo se-celiac. Isikhathi esiphakathi kwezifundo zokufunda kwakuyiminyaka engama-63 ubudala.
Ngesikhathi esilandelayo esingaphezu kweminyaka eyisishiyagalombili, ukugula komqondo kutholakala emaphesenti angu-4.3 kulabo abanesifo se-celiac futhi ngamaphesenti angu-4.4 eqenjini lokulawula.
"Kuyasiqinisekisa ukuthi asizange sithole ingozi eqinile," kubhala abalobi.
Ucwaningo lwaveza ingozi eyengeziwe yokuxilongwa kwe-dementia ngonyaka wokuqala emva kokuxilongwa kwesifo se-celiac. Kodwa-ke, lo mngcipheko awuzange udlule ngaphezu kwalowo nyaka wokuqala, futhi abalobi bezocwaningo bathi kungenzeka ngenxa yokuthi labo abasesifundweni bahlolisiswa ngokucophelela, futhi izimo zezokwelapha ezazikhona kakade kodwa zingakabonakali zikhona ngaphezulu kungenzeka ukuthi atholakale futhi aphathwe ngenxa yalokhu.
I-Vascular Dementia Risk Kungenzeka ikhuliswe
Ngokuphathelene nalokhu, lolu cwaningo luye lwaveza ingozi encane yokwehla kwesifo sengqondo se-vascular-type of dementia eyabangela ukwehla kwegazi ku-brain yakho-phakathi kwabantu abanesifo se-celiac. Lokhu kungabangela inkinga, abalobi babhala, ngoba abantu abanesifo se-celiac banezingozi ezincane zengozi ye-cardiovascular, okuphakamisa ingozi yokudangala komzimba.
Kungenzeka ukuthi le nengozi eyengeziwe yokwehla kwesifo sengqondo se-vascular can be due to a lack of vitamin-in particular, in vitamin B12, abalobi babhala. Kodwa-ke, ucwaningo olungaphezulu luzodingeka ukuthi lunqume ukuthi lokhu kuyiqiniso yini.
"Ukuthola kwethu ingozi eyingozi yokwehla kwesifo sengqondo somzimba (hhayi i-Alzheimer's 'dementia') kungase kwenzeke ngenxa yengozi kodwa kuphakamisa ukuthi kungenzeka ukuthi ukugula komfutho wegazi kungase kube umphumela wesikhathi eside sesifo se-celiac esifana nesengozini esasungulwe ngaphambili se-cardiovascular and cerebrovascular disease , "abalobi baphetha.
Ucwaningo Olwengeziwe Kungenzeka ku-Alzheimer's and Celiac
Nakuba isifundo esivela eSweden siwubufakazi obunamandla bokuthi isifo se-celiac asikhulisi ingozi yokugula kwesifo sengqondo kanye nesifo se-Alzheimer's, cishe ngeke kube yinto yokugcina kule ndaba. Ucwaningo oluthile lwabantu asebekhulile luye lwasikisela ukuthi ukungenisa kwe-gluten kungase kube kubi nakakhulu noma kubangele ukulimala kwe-Alzheimer nezinye izinhlobo zabantu abanesifo se-celiac.
UDkt. Fasano uthi ulindele ukucwaninga okuqhubekayo ukuqhubeka nokuhlola lolu daba: "Ukunquma ngempela ukuthi kukhona ubuhlobo phakathi kwesifo se-celiac nesifo se-Alzheimer sekwephuzile, sidinga izifundo ezizobe zilandela abantu esikhathini eside. , singakwazi ukunquma ukuthi isifo se-celiac sithinta kanjani ukuthuthukiswa kwesifo se-Alzheimer noma ezinye izinhlobo ze-dementia nokuncipha kwengqondo. "
Olunye ucwaningo lwathola ukuthi i-subset yezakhi zofuzo ezihlobene nesifo se-celiac nezinye izifo ezizimele , ezihlanganisa isifo samathambo nesifo sofuba, futhi sihlobene nesifo se-Alzheimer.
Isici esivamile sibonakala sokuvuvukala, abalobi abathandwayo babhala. Kodwa futhi, ucwaningo olwengeziwe luyadingeka kulezo zakhi zofuzo nemiphumela yazo ukuze kukhishwe ukuxhumana okukhona.
Akukho Ubufakazi Bokufaka Izimangalo ku- Grain Brain
Ungase ujwayelene nesazi sezinzwa zezinzwa uDkt. David Perlmutter, umbhali weGrain Brain, obeka amaprotheni en gluten ezinqolobaneni zebolweni, ibhali, ne-rye (futhi ngezinga elithile, zonke izinhlobo) ekunciphiseni impilo yobuchopho ukuthi kwezinye izimo kuholela ekudemeni kwengqondo. Imithi yakhe yokwelapha ukugwema i-carbs esekelwe okusanhlamvu, ikakhulukazi i-gluten.
UDkt. Perlmutter's Grain Brain uxwayisa ukuthi ukolweni (nezinye izitshalo) kungalungile empilweni yobuchopho kuwo wonke umuntu, hhayi nje labo abanesifo se-celiac noma ukuzwela kwe-gluten okungenayo i-celiac. Usola ukwanda kwe-ushukela wegazi ohlobene nokusetshenziswa okusanhlamvu, uthi lokhu kubangelwa ukumelana ne-insulin kanye nesifo somzimba, isifo sikashukela, futhi ekugcineni ukwehla kwengqondo nokuhlupha komqondo.
Inkinga iwukuthi, iziphetho zikaDkt Permutter zisekelwe ngokuyinhloko ngobufakazi bakhe bokuthi u-anecdotal, futhi ayisekelwa yizifundo zempilo eziqinile. Akukho bufakazi besayense obonisa ukuthi i-gluten kanye / noma okusanhlamvu kungabangela isifo se-Alzheimer noma ezinye izinhlobo ze-dementia.
Ukuvuvukala ne-Microbiome
Omunye usosayensi ofunda umbuzo wokuthi ingabe ukungenisa kwe-gluten kungabangela ukucindezeleka kwengqondo kulabo abanomqondo wokuzwela okungenalo i-celiac gluten nguDkt. Mak Daulatzai, isazi sezinhliziyo kanye nocwaningo oluphezulu lwezokwelapha e-University of Melbourne e-Australia. Ngokusho kwephepha le-2015 likaDkt. Daulatzai, ukuguqulwa kwe-microbiome yakho yegciwane okubangelwa ukungazweli okungenayo i-celiac kungabangela ukuvuvukala komzimba wonke, okuzoholela engozini yokwanda kwengqondo nokugula kwesifo se-Alzheimer.
UDkt. Daulatzai uthi: "Imizimba yethu ibekezelela ukudla okuningi futhi ayifuni ukubhekana nokuzivikela komzimba." "Nokho, uma kwenzeka i-gluten, [ezinye izidumbu zomuntu] zibhekwa njengento engokwemvelo," futhi isabela kuyo. Lokhu kubangela ukuvuvukala, uthi, futhi "kungabangela ukubonakaliswa kwengqondo / kwengqondo neyesifo sezinzwa" zobuningi bokungaboni kahle kwe-gluten, okungenzeka kufaka phakathi ukuwohloka komqondo.
UDkt. Daulatzai uthi le ndlela ehlongozwayo yokudemeka kwengqondo ihlala ingacabangi futhi ingavunyelwe, nakuba ebona ithimba lakhe lisebenza ocwaningweni olungahle linikeze umbono wakhe.
Okubalulekile
Ubufakazi besikhathi samanje bubonisa ukuthi ukuba nesifo se-celiac asiphakamisi isifo se-Alzheimer noma ukuwohloka komqondo. Phakathi naleso sikhathi, akukho bufakazi bezokwelapha obonisa ukuzwela kwe-gluten kungabangela ingozi yakho kulezi zimo ezimbili ezihlobene nobuchopho-nakuba ucwaningo lukaDkt. Daulatzai luhlongoze ukuthi kungenzeka yini ukuxhumanisa okunjalo, luhlala lingavunyelwe futhi lungacabangi.
Ngakho-ke uma ukudla okungenalutho kwe-gluten kunezinzuzo ezicacile zempilo yakho uma unesifo se-celiac noma ukuzwela kwe-gluten, ngeshwa ngeke ukwazi ukuyivikela ekuguleni kwesifo se-Alzheimer noma ukuwohloka komqondo. Ngenhlanhla, kunezinye izindlela ongasiza ngazo ekunciphiseni ingozi ye-Alzheimer's , kuhlanganise nokuvivinya umzimba (kokubili ngokomzimba nangokwengqondo).
> Imithombo:
> Daulatzai MA. Ukungahloniphi kwe-Celiac Gluten Ukuhlushwa kwe-Gut Dysbiosis, i-Neuroinflammation, i-gut-Brain i-Axis Dysfunction, nokuhlukunyezwa kwe-Dementia. I-CNS & Neurological Disorders - Izinjongo Zezidakamizwa. 2015; 14 (1): 110-31.
> Lebwohl B et al. Ingozi ye-Dementia ezigulini ezinezifo ezibucayi: Isifundo se-Co-Based Cohort. I-Journal yezifo ze-Alzheimer. 2016; 49 (1): 179-85.
> McKeon A et al. Okubalulekile Kwama-Neurologic Ama-Biomarker Wezifo Eziphilayo. I-Neurology. 2014 Nov 11; 83 (20): 1789-96.
> Yokoyama JS et al. Ukuhlangana Phakathi Kwezakhi Zamafuzo Ezifo Ezifakwe Emzimbeni Kanye Ne-Alzheimer's Disease. I-JAMA Neurology . 2016 Jun 1; 73 (6): 691-7.