Cabangela ukuguqulwa kwesikhathi eside kanye nokwelapha
Ukuhlukumeza ngokweqile kungaba yisimo esinzima sokuphatha, ngokulala ngokweqile ukulala kwansuku zonke kanye nobuthakathaka obusheshayo obubizwa ngokuthi i- cataplexy . Ngakho-ke, kuyinto engokwemvelo ukuzibuza mayelana nokubikezelwa kwesikhathi eside.
Nakuba kancane kancane sithola ukuqonda okungcono kwesifo kanye nezindlela zokwelapha, umbuzo uhlala: Ingabe ukuhlukunyezwa kuyaqhubeka?
Funda ngombono okhona wamanje wokuthi kungani kuvela izidakamizwa futhi ngabe imbangela ebangelwayo ingaguqulwa.
I-Autoimmune Element
Kukholelwa ukuthi ukuhlukumeza ngokweqile kubangelwa inqubo yokuzimela. Amasosha omzimba anesibopho sokulwa nezifo, kodwa ngezinye izikhathi leli arsenal elinamandla liphendukele emzimbeni uqobo.
Uma lokhu kwenzeka, izimpikiswano ezithile zingase ziholele, kuhlanganise nesifo sofuba, isifo samathambo, ngisho nokuhlukumezeka. Kukhona ubufakazi obukhulayo bokuthi ukutheleleka kungabangela umzimba ukuba uziphendulele ngokwawo kubantu abathile abangenwe yisifo ngenxa yezinto eziphilayo.
Ngokwezinkinga zokuzivikela, isimiso somzimba samasosha omzimba siqala ukukhomba nokubhubhisa inani elincani le-neurons ngaphakathi kwe- hypothalamus yobuchopho. Lawa-neurons, noma amangqamuzana omzimba, aqukethe i-neurotransmitter ebizwa ngokuthi i- hypocretin noma i-orexin.
Njengoba lesi sifo sishintsha, yonke iqoqo lama-60,000 kuya ku-70,000 amaseli ayisisindo e-hypothalamus abhujiswa unomphela. Ngenxa yalokho, izinga le-hypocretin elitholakalayo ku-cerebrospinal fluid (i-CSF) eligeza ubuthongo luyehla ku-zero.
Lokhu kungalinganiswa nge- lumbar puncture . Uma iziguli zinezinhlanzi, uhlobo lobubuthakathaka olubangelwa imizwelo, amazinga e-hypocretin ngokuvamile ayenayo futhi lokhu kubonisa uhlobo lwe-1 lwe-narcolepsy.
Ngaphezu kwalokho, le nqubo yokulimaza eyonakalisayo ingase icasuliwe ngemuva kokutheleleka (ngokuvamile kubanda noma umkhuhlane).
Muva nje, ingozi eyengeziwe yokwelashwa kwatholakala ngokulandela ukugoma ngePandemrix, umgomo wokugoma we-H1N1 wemvelo owenzelwe umkhuhlane we-2009-2010 futhi wasebenzisa kuphela eYurophu. Ukusetshenziswa sekulokhu kuqedwe.
Isimo Esiyingozi
Ngeshwa, ukubhujiswa kwala maseli obuchopho ngokuvamile kuqedile futhi ukulahleka okubangelwa yiyo unomphela. Umonakalo owenziwe awukwazi ukuguqulwa okwamanje. Ngakho-ke, i-narcolepsy yisimo esingapheli esidinga ukwelashwa okuqhubekayo.
Kunezinhlobo eziningi zokwelashwa ezingase zisebenze ekuphatheni izimpawu ezihlobene ne-narcolepsy. Lezi zingabandakanya imithi evuselelayo, njenge- Provigil noma i- Nuvigil , kanye nemithi evimbela i-cataplexy, njenge- Xyrem .
Uma uhlushwa yi-narcolepsy, kubalulekile ukuthi ukhulume nomchwepheshe wokulala ongakwazi ukulungisa ukwelashwa ngezidingo zakho ezithile. Nakuba ukukhubazeka kuvame ukuphikelela, abanye abantu bayakwazi ukwenza izinguquko ngokusetshenziswa kwemithi ukuze balondoloze imisebenzi eminingi yansuku zonke.
Ithemba lihlala eminyakeni ezayo. Izindlela ezintsha zokwelapha zingakwazi ukuvimbela, ukuphuza, noma ukuguqula ukubhujiswa kwala maseli anesifo se-hypocretin kubantu abangenakwenzeka. Ukuvuselelwa kwalesi sibalo samangqamuzana obuchopho abane-stem cell transplants kungase futhi kwenzeke ekugcineni.
Yize lezi zindlela zokungenelela zisesekude kakhulu, kusenokwenzeka ukuthi kungenzeka ukuthi usuku olulodwa lokuhlukunyezwa lungase luphele kulabo abahluphekile.
Imithombo:
I-CDC isitatimende sokwehlukana kwezidakamizwa kulandela ukugoma kwe-Pandemrix influenza eYurophu.
Kryger, MH et al . "Izimiso Nemikhuba Yokulala Imithi." Elsevier , edition 5. 2011.