Sibutsetelo se-Narcolepsy Chemical Orexin

I-Chemical Messenger ebuchosheni bakho obangela ukuhlukumezeka

Incazelo

Ekhiqizwa endaweni yechungechunge okuthiwa yi- hypothalamus , i-orexin ingenye yezithunywa zamakhemikhali, noma i-neurotransmitters, echaphazela ubuchopho futhi ivuselela ukudla, ukuphumula nokusetshenziswa kwamandla. Ososayensi bathola i-orexin ngo-1998, futhi bebecwaninga indima yabo ebuthongweni nokuvusa, kanye nokwelashwa kwezifo zokulala.

I-Orexin, ebizwa nangokuthi i-hypocretin, iyingxenye yeklasi yamakhemikhali okuthiwa ama-hormone we-neuropeptide exitatory. Kunama-peptide amabili ahlukene ane-chemical structure structure, eyodwa eyaziwa njenge-orexin-A (noma i-hypocretin-1) kanti enye i-orexin-B (noma i-hypocretin-2). Ukuntuleka kwe-Orexin kungaphazamisa ikhono lomzimba lokuhlala liphapheme futhi lilele, ubunzima obungabangela ukuhlukumeza .

I-Orexin ne-Narcolepsy

Kubantu abalala ngokulawulwa kahle, ama-orexins akhululwa uma ephapheme futhi esisiza ukwandisa umsebenzi ema-neurons okhuthaza ukuvuka nokucindezela ukulala kwe-REM - ubuthongo obunzima lapho amaphupho ekhona.

Uma umuntu enesifo esiphuthumayo, esibhekene nokulala ngokweqile emini futhi elele ngaphandle kokuxwayisa, kungenxa yokuthi i-neurons yabo yokukhiqiza i-orexin ifile. Ngaphandle kwama-orexins, umuntu onesifo se-narcolepsy akakwazi ukulawula ukulala kwe-REM. Kwezinye izimo, ukuphupha okuvame ukwenzeka ngesikhathi sokulala kwe-REM kungenzeka uma umuntu ephapheme, okuholela ekuhloleni okufana nephupho.

Kodwa kungani ama-orexin efa ekuqaleni? Abacwaningi bakholelwa ukuthi ukuhlukunyezwa kwesibindi kubangelwa ukuhlasela okuzenzakalelayo kwe-orexin neurons. Ngokujwayelekile, abantu abanezinkinga ze-narcolepsy bazobe bekhuphuka amazinga e-antibodies alwa ne-streptococcus, okungukuthi amabhaktheriya abangela ukusakazeka komgudu . Lokhu kusikisela ukuthi ukuhlasela okuzenzakalelayo kubangelwa ukusuka noma ukunye ukutheleleka kwasebusika, ikakhulukazi ngoba i-narcolepsy ivame ukuvela entwasahlobo ka-late noma ekuqaleni kwehlobo.

Ukwelapha i-Orexin yokuphazamiseka kokulala

Uma ukuntuleka kwama-orexin kubangele ukuphazamiseka kokulala, ngabe kungengqondo ukuthi ama-orexin angakusiza ukugcina uphapheme, kunjalo? Iklasi lezidakamizwa, okuthiwa i-orexin receptor antagonists, lisandulwe ukuphatha izifo zokulala, ezifana nokulala. Lezi zinsiza zokulala zihlose i-orexin action, ivimba ukubonakaliswa kwe-orexin ebuchosheni. I-Orexin idlala indima ekwenzeni abantu baphapheme futhi beqaphile, ngakho ukuvimbela kwabo kukhuthaza ukulala.

I-Orexin receptor agonists ihluke kwezinye izigulane zokulala kanye nezinsizakalo zokulala zokulala lapho zikhomba uhlelo oluthile lwamakhemikhali ahlukene nakwezinye izindawo ebuchosheni. I-Suvorexant, ethengiswa ngaphansi kwegama elithi Belsomra, ingowokuqala kwalesi sifundo sesidakamizwa okufanele itholakale.

Hlola lezi zinsiza ukuze uthole ulwazi oluningi mayelana ne-narcolepsy nezinye izinkinga zokulala:

Ukuxilongwa kwe-Narcolepsy

Izivivinyo zokuxilonga zezinkinga zokulala

Thola Izimpawu Nezimbangela Zokuqwashisa

Sibutsetelo sokukhathazeka okuvamile kokulala

Amaphilisi Okulala Angasiza Ngosizi Kodwa Ingabe Akufanelekile?

Izici Ezichaza Ezizine Zezinkinga Zokuhlukumezeka

_Imithombo:

_{I-Division of Sleep Medicine eHarvard Medical School. (2013, Januwari 19). I-Science of Narcolepsy. Ibuyiselwe ngo-Februwari 06, 2016.}

_{I-National Sleep Foundation. (nd). Ama-antagonist receptor antagonists: Ikilasi elisha lepilisi yokulala. Ibuyiselwe ngo-Februwari 06, 2016}