Ingabe Ukudla Okungenayo I-gluten Kungasiza Ukuphatha Izifo ZikaLou Gehrig?
Abanye abantu abanesifo sengqondo esesabekayo i-amyotrophic lateral sclerosis - eyaziwa nangokuthi i-ALS, noma isifo sikaLou Gehrig - sinamazinga aphakeme okuthiwa i-antibody e-gluten ejikeleza emizimbeni yawo, ephakamisa umbuzo wokuthi ukudla okungekho gluten kungasiza ekwelapheni lesi sifo, ukuboniswa kwesifundo.
Kodwa-ke, abacwaningi abaqhuba ucwaningo baxwayisa ukuthi ukutholakala kwalo kuyisiqalo futhi kufanele kuqinisekiswe ngokuphenywa okuqhubekayo ngaphambi kokuba odokotela bacabange ukuphatha iziguli zabo ze-ALS ngezilwane ezingenalutho.
Abososayensi, baseTel Aviv Medical Center e-Israel, okwamanje baqhuba ukuhlolwa kokuhlolwa kokulandela imiphumela ye-go gluten-free kwiziguli ze-ALS ezinamagciwane okulwa ne-gluten.
"Idatha evela kulolu cwaningo ibonisa ukuthi, kwezinye izimo, i-ALS syndrome ingase ihlotshaniswe nokuzizwa komuntu kanye nokuzwela kwe-gluten," abacwaningi babhala kulolu cwaningo, olwanyatheliswa ngo-Ephreli 2015 encwadini yezokwelapha i- JAMA Neurology . "Nakuba idatha ingu-preliminary futhi idinga ukuphindaphindiwe, ukuzwela kwe-gluten kungaphathwa kahle; ngakho-ke, le nselele yokuxilonga akufanele inganakwa."
Ukwelashwa kwe-ALS Kungaba Okubalulekile
I-ALS yisifo esiphuthumayo sezinzwa eziholela ekugcineni imiphumela - ngokuvamile phakathi neminyaka embalwa yokuxilongwa - ekukhubazeni nasekufeni. Abantu abangaba ngu-5 600 batholakala ukuthi bane-ALS unyaka ngamunye e-US, futhi isimo sivame kakhulu phakathi kweminyaka engama-40 no-60. Lesi sifo sibangela ukuwohloka kwengxenye yomgogodla obhekene nokunyakaza.
Ungase ujwayelane nesimo esivela emphakathini omkhulu owenziwe ehlobo ka-2014 yi-ALS Ice Bucket Challenge, eyayihlasela ama-social media futhi yakhulisa ngaphezu kwezigidi eziyizigidi zamaRandi ukuxhasa nokucwaninga kwe-ALS.
Ukuthola ukwelashwa kwe-ALS okusiza abanye abantu ukuba bathuthuke - ngisho noma leyo yokwelashwa isebenzayo kuphela esakhiweni esincane salebo abane-ALS - kuyoba okuphawulekayo.
Njengamanje, kunomuthi owodwa kuphela ovunyelwe i-ALS, futhi ukwelashwa kuhloswe ukugxila ekuqhubekeni kokuqhubeka kwezimpawu ngenkathi kusiza iziguli zisingatha izimpawu zabo kangcono.
Lesi akusona okokuqala ukuthi odokotela baphakamise uxhumano phakathi kwesifo se-celiac kanye / noma ukungazweli kwe- gluten non-celiac ne-ALS. Imibiko emibili yecala eshicilelwe ichaza iziguli ezaqala ukutholakala nge-ALS, kodwa kamuva zatholakala ukuthi zikhona ngesifo se-celiac futhi izimpawu zabo zithuthuka uma zihamba zingenayo igundane.
Kodwa-ke, isifundo esikhulu eshicilelwe ngo-2014 sehlulekile ukuthola ukuxhumana phakathi kwesifo se-celiac, ikakhulukazi, futhi kamuva sitholwa i-ALS.
Isifundo se-Tel Aviv sibheke ama-antibodies angavamile
Lolu cwaningo lwamuva olwenziwa kubacwaningi base-Israel luhlanganisa iziguli ezingu-150 ze-ALS ezihlolwe ngokulandelana phakathi kukaJulayi 2010 noDisemba 2012, kanye nezifundo ezingu-115 zokulawula okunempilo ezifakiwe ukuqhathaniswa.
Abacwaningi benza ukuhlolwa kwegazi kuma-gluten antibodies ahlobene nesifo se-celiac futhi bathola ukuthi akekho wabantu kulelo qembu lalinalowo ma-antibodies, okusho ukuthi cishe ayengenayo isifo se-celiac.
Abacwaningi babuye bafuna uhlobo oluhlukile lwe-anti-gluten ebizwa ngokuthi i-IgA-Transglutaminase-6 (IgA-TG6), engabandakanyeki nesifo se-celiac.
Kodwa-ke, i-IgA-TG6 ixhunyaniswe kwezinye izifundo ku- gluten ataxia , isimo segazi esisodwa segazi lapho umzimba uphendula khona ekusebenziseni kwe-gluten ngokuhlasela ama-neuron awo. I-gluten ataxia ingaholela ekukhubazekeni okuphawulekayo, okuqhubekayo ezimweni ezimbi.
Ucwaningo lwathola ukuthi iziguli ezingu-23 ze-ALS - noma u-15.3% - zaziphethe ama-antibodies aphezulu e-IgA-TG6, uma kuqhathaniswa nezihloko ezingu-4.3% zokulawula. Ngaphezu kwalokho, cishe ama-59% wezilwane ze-ALS ezinama-antibodies we-gluten nazo zithatha okungenani i- gene eyodwa yesifo se-celiac .
Lezi ziguli ze-ALS ezazinama-antibodies okuthiwa yi-IgA-TG6 eziphuma emigodini yegazi zibonisa ukuthi leli qembu libiza ngokuthi "isithombe se-ALS," esifana neziguli ze-ALS ngaphandle kwama-anti-gluten - ngamanye amazwi, odokotela abazange bakwazi ukutshela amaqembu amabili .
Ngakho-ke Konke Lokhu Kusho Ukuthini?
Lokhu akucaci okwamanje. Njengoba ngibhala ngenhla, abacwaningi abathintekayo kulolu cwaningo baxwayisa kakhulu ngokufunda okuningi kulo, nakuba behlola ukuthi ngabe i-gluten-free ingasiza yini ekuphatheni ama-ALS, okungenani esigabeni esithile sabantu abanezigciwane zamaguten ze-IgA-TG6.
Uma ukutholakala kwabo kulandelwa, isinyathelo esilandelayo singase senze isilingo somtholampilo ukuze sibone ukuthi ukudla okungenayo i-gluten kungazuzisa iziguli ezine-ALS kanye ne-IgA-TG6. Izinhlelo zokufunda okunjalo ziyaqhubeka. "Ukutadisha kwethu kusikisela ukuthi i-ALS syndrome ehlobene nokuzwela kwe-gluten ingase ivele kunxenyana yeziguli nokuthi i-TG6 IgA autoantibodies ingaba uphawu lokukhomba iziguli ezizwelayo," kusho abacwaningi.
Imithombo:
Brown KJ et al. Izilonda zendaba ezimhlophe zibonisa ukuthi i-amyotrophic lateral sclerosis ibangelwa isifo se-celiac. I-American Journal ye-Neuroradiology . 2010 Meyi; 31 (5): 880-1.
UGadoth A et al. I-Transglutaminase 6 Antibodies eSerum yeziguli ezine-Amyotrophic Lateral Sclerosis. I-JAMA Neurology . Ishicilelwe ku-intanethi ngo-April 13, 2015.
Ludvigsson JF et al. Ayikho inhlangano phakathi kwesifo se-celiac esiqinisekisiwe se-biopsy kanye ne-amyotrophic lateral sclerosis elandelayo. I-European Journal ye-Neurology . 2014 Jul; 21 (7): 976-82.