I-gluten ataxia yisimo esingavamile sokuzenzakalela esingalimaza ubuchopho bakho
I-gluten ataxia, isimo esivamile esingavamile segazi ngokwemvelo esihilela ukusabela komzimba wakho kumaprotheni we- gluten okutholakala ngokolweni, ibhali ne-rye, kungalimaza ngokungenangqondo ingxenye yengqondo yakho ebizwa ngokuthi i-cerebellum, ngokusho kwabasebenzi abaqale baveza isimo seminyaka eyishumi eyedlule.
Lo monakalo okungenzeka ungabangela izinkinga ngekhono lakho kanye namakhono akho amakhono amakhulu, okuholela ekulahlekelweni kokuxhumana futhi mhlawumbe okuholela ekukhubazekeni okukhulu, okuqhubekayo kwezinye izimo.
Kodwa-ke, ngenxa yokuthi i-gluten ataxia iyinto emisha kakhulu, futhi akuwona wonke odokotela abavuma ukuthi ikhona, kunjengekho okwamanje ayikho indlela eyamukelekile yokuyihlola noma yokuyihlola.
Kodwa lokho kungase kushintshe: iqembu labacwaningi abaphezulu emkhakheni wezifo ze- celiac kanye nokuzwela kwe-gluten okungewona i-celiac kukhishwe isitatimende sokuvumelanisa ngendlela odokotela abangathola ngayo zonke izimo ezihlobene ne-gluten, kuhlanganise ne-gluten ataxia.
E-Gluten Ataxia, Antibodies Hamba i-Cerebellum
Uma une-gluten ataxia, izifo zomzimba umzimba wakho okhiqiza ngokuphendula ukungenisa kwe-gluten ngokushaya kabi ihlasela i-cerebellum yakho, ingxenye yobuchopho bakho obhekene nokulinganisela, ukulawulwa kwezimoto, kanye nezwi le-muscle. Isimo sisebenza ngokuzenzakalelayo emvelweni, okusho ukuthi kuhilela ukuhlaselwa okungalungile okwenziwe yisifo sakho-amaseli egazi amhlophe ahlanzekile, okwakhiwa yi-gluten ingestion, ngokumelene nokuhlasela okuqondile ebuchosheni ngeprotheyini ye-gluten ngokwayo.
Ngakwesokunxele, lokhu kuhlasela okuzenzakalelayo kuvame ukuqhubeka kancane, kodwa izinkinga ezibangelwa ukulinganisela nokulawulwa kwezimoto ekugcineni zingenakunyakaziswa ngenxa yokulimala komqondo.
Iziguli ezifika ku-60% ezine-ayxia ye-gluten zinokufakazela ukuthi i-cerebellar i-atrophy-literally, i-shrinkage yaleyo ngxenye yobuchopho bayo-lapho ihlolwa nge-technology magnetic resonance imaging (MRI). Kwamanye abantu, i-MRI nayo izoveza izindawo ezikhanyayo ezimhlophe ebuchosheni obonisa umonakalo.
Bangaki Abantu Abahluphekayo KuGluten Ataxia?
Ngenxa yokuthi i-gluten ataxia yinkinga enjalo esanda kuchazwa futhi akuwona wonke odokotela abamukela njengamanje, akucaci ukuthi bangaki abantu abangase bahlupheke kuso.
UDkt. Marios Hadjivassiliou, isazi sezinzwa zezokwelapha esiseSheffield Teaching Hospital e-United Kingdom kanye neurologist esazichaza okokuqala i-gluten ataxia, ithi abaningi abangaba ngu-41% wabo bonke abantu abane-ataxia abanesizathu esaziwayo bangase babe ne-gluten ataxia. Ezinye izilinganiso zibeke lezo zibalo ezingezansi - endaweni ethile ku-11.5% kuya ku-36%.
Njengoba i-ataxia ngokwayo isimo esingavamile-esithinta abantu abangu-8,4 kuphela kulawo wonke ama-100,000 e-US-lokho kusho ukuthi bambalwa abanamatholethi ase-gluten. Kulinganiselwa kakhulu kunani labantu abanesifo se-celiac ne-gluten ukuzwela okungenayo izimpawu ze-neurological.
I-Gluten Ataxia: Izinkinga ze-Neurological ze-Gluten
Izimpawu ze-gluten i-ataxia azifani nezimpawu zenye izinhlobo ze-ataxia. Uma unayo i-ataxia ye-gluten, izimpawu zakho zingase ziqale njengezinkinga zokulinganisela ezincane-ungahle ube unyawo oluqinile, noma unenkinga yokuhambisa imilenze yakho.
Njengoba izimpawu ziqhubeka, abanye abantu bathi bayahamba noma bakhulume sengathi baphuze. Njengoba ukulimala okuzenzakalelayo ku-cerebellum yakho kuqhubekela phambili, kungenzeka ukuthi amehlo akho azohileleka, angase ahambe ngokushesha nangaphandle ngokuzibandakanya.
Ngaphezu kwalokho, amakhono akho amakhono emoto angase ahlupheke, okwenze kube nzima kuwe ukusebenzisa izingobho zokubhala, i-zip zippers, noma ukusebenzisa izinkinobho ezembatho zakho.
Ukuxilonga Akuhambisani Ne-Gluten Ataxia
Njengoba akuzona zonke odokotela abamukela i-gluten ataxia njengesixilongo esivumelekile, akubona bonke odokotela abazokuvivinya ngesimo uma ubonisa izimpawu. Ngaphezu kwalokho, ochwepheshe emkhakheni we-gluten-infected disease usanda kuhlakulela ukuvumelana mayelana nendlela yokuhlola i-gluten ataxia.
Ukuxilongwa kwe-gluten ataxia kuhilela ukusetshenziswa kwezivivinyo eziqondile zegazi le-celiac , nakuba kungewona uvivinyo olubhekwa njengelona olunembile kunazo zonke ukuhlola isifo se-celiac . Uma noma yikuphi kwalezi zivivinyo kubonisa umphumela omuhle, udokotela kufanele anikeze ukudla okunomsoco okukhululekile kwe- gluten .
Uma izimpawu ze-ataxia ziqinisa noma zithuthukisa ukudla, khona-ke kubhekwa njengesibonakaliso esinamandla sokuthi i-ataxia yayingenwe-gluten, ngokuvumelana nesitatimende sokuvumelana.
I-Gluten Ataxia Ukwelashwa Ibandakanya Ukudla Okunamandla Kwe-Gluten
Uma uthola ukuthi une gluten ataxia, udinga ukulandela ukudla okunamandla kakhulu kwe- gluten ngokungakhohlisi neze, ngokusho kukaDkt. Hadjivassiliou.
Kunesizathu salokhu: izimpawu zezinzwa ze-gluten zokungenisa zibonakala zithatha isikhathi eside ukuthuthukisa izimpawu zomzimba, futhi kubonakala sengathi zizwela kakhulu ukulinganisa okulandelanayo kwe-gluten ekudleni kwakho, kusho uDkt. Hadjivassiliou. Ngakho-ke, kungenzeka ukuthi ungenza umonakalo owengeziwe kuwe uma uqhubeka nokufaka ingcosana ye gluten.
Yiqiniso, akuwona wonke odokotela abavumelana nalokhu kuhlola, noma ngabe kunjalo neseluleko sokudla i-gluten uma ungenayo i-ataxia engacacisiwe namazinga aphezulu e-anti-gluten. Kodwa-ke, kubonakala sengathi ixhaswa yimbiko ye-anecdotal evela kubantu abane-atxia ye-gluten etholakele kubantu abanobunzima obukhulu bezinzwa ezihlobene nesifo se-celiac: Labo bantu bathi izimpawu ze-neurological kuthatha isikhathi eside ukuxazulula; kuyilapho ezinye zizinzile kodwa zingalokothi zithuthuke.
Izwi kusuka
Inani labantu abanesifo se-gluten abanesifo se-gluten sincane kakhulu uma kuqhathaniswa nezinombolo zabantu abane-celiac isifo, futhi ncane uma kuqhathaniswa nezilinganiso zokuthi bangaki abantu abanokuzwela kwe-gluten .
Kodwa-ke, abantu abaningi abanesifo se-celiac ne-gluten ukuzwela nabo babhekana nezimpawu ze-neurological , ezivame ukuhlanganisa ne- gluten-related related peripheral neuropathy kanye ne- migraine . Abanye futhi bakhononda ngezinkinga zokulinganisela ezibonakala zixazulula uma zihamba zingenalutho.
Kungenzeka ukuthi, njengoba kuqhutshwa izifundo eziningi kwi-ataxia ye-gluten, abacwaningi bayothola izixhumanisi ezinamandla phakathi kwalesi simo, isifo se-celiac, nokuzwela kwe-gluten. Okwamanje, uma unezimpawu ezifana ne-gluten ataxia, khuluma nodokotela wakho. Ungadinga ukuhlola ukuthola ukuthi unesinye isimo esingabangela izimpawu ezifanayo.
Imithombo:
UFasano A. et al. I-spectect yezinkinga ezihlobene ne-gluten: ukuvumelanisa ngokuchazwa kwamagama okusha nokuhlukaniswa. BMC Medicine. BMC Medicine 2012, 10:13 ini: 10.1186 / 1741-7015-10-13. Kushicilelwe: 7 Februwari 2012
Hadjivassiliou M. et al. Ukwelashwa Kwempilo KaGluten Ataxia. Journal of Neurology, Neurosurgery and Psychiatry. 2003; 74: 1221-1224.
Hadjivassiliou M. et al. I-gluten ataxia enombono oqondile: izifo ze-epidemiology, ukutholakala kwezakhi zofuzo kanye nezici zomtholampilo. Ubuchopho. 2003 Mar; 126 (Pt 3): 685-91.
Hadjivassiliou M. et al. I-Gluten Ataxia. I-Cerebellum. 2008; 7 (3): 494-8.
Rashtak S. et al. I-Serology ye-celiac isifo se-ataxia esibhekene ne-gluten noma i-neuropathy: indima ye-antiamidated gliadin antibody. I-Journal ye-Neuroimmunology. 2011 Jan; 230 (1-2): 130-4. Epub 2010 Nov 6.