Ukuqaphela Izimpawu ze-PML ngokuqondene nalabo abakwa-MS Ukubuyela emuva
I-legoencephalopathy ye-multifocal leukoencephalopathy (i-PML), iyisifo esingavamile kodwa esibulalayo esibangelwa yi -JC virus . Leli gciwane livame ukuhlolwa ngesistimu yakho yomzimba ukuze ingabangeli umonakalo.
Kodwa-ke, uma amasosha omzimba wakho ebuthakathaka yisifo, njenge- HIV / AIDS , i- leukemia , i-lymphoma, noma omunye umdlavuza, noma unqunywe yimithi, igciwane lingase livuselele futhi lilimaze ubuchopho bakho.
Ukulimala komqondo okubangelwa i-PML kungaholela ezinhlobonhlobo ezihlukahlukene.
Ngenkathi i-PML ingavamile kakhulu, kuyinkinga enkulu uma une-multiple sclerosis (MS) ngoba ezinye imithi yokuzivikela ekusebenziseni ukwelashwa isanda ingozi yokuthuthukisa i-PML.
I-Tysabri (natalizumab) ibonakala ihlotshaniswa nengozi enkulu kunazo zonke ze-PML. Kodwa-ke, ezinye izifo ze-MS zokuzivikela zingase zibe nengozi, kuhlanganise noGilenya (fingolimod), i-Tecfidera (dimethyl fumarate), i-Ocrevus (ocrelizumab), futhi mhlawumbe nabanye.
Izimpawu ze-PML
I-MS ngokwayo ayinyuli ingozi ye-PML. Kodwa uma wena noma othandekayo ethatha imishanguzo yokuguqula izifo ezithintela isimiso somzimba sokuzivikela, ukuzijwayeza ngezimpawu ze-PML ikuvumela ukuba usebenze futhi ulandelelwe ekuqapheleni lokhu kusebenza okunzima okukhulu.
Njengezimpawu ze-MS, lezo ezihlobene ne-PML ziyahlukahluka, kuye ngokuthi indawo (s) zobuchopho ezithintekile.
Izimpawu zingafaka:
- Ubuthakathaka, ngokuvamile ohlangothini olulodwa lomzimba
- Ikhono lokucabanga elikhubazekile, okuvame ukuveza ukudideka kanye / noma ukulahlekelwa inkumbulo
- Kunzima ukukhuluma
- Ukubambisana okungalungile, ngokuvamile okuhlangenwe nakho njengokuhlushwa noma ukuhamba ngezinkinga
- Izinkinga ezibonakalayo, njengombono ophukile noma ukungaboni ngokucacile endaweni ethile yendawo yakho ebonakalayo
- Izinguquko zomuntu
- Izinzwa ezingavamile noma ukulahlekelwa kwesifo endaweni yomzimba wakho
- Ukuzizwa, nakuba lokhu kungavamile
PML vs. MS Kubuyela emuva
Izimpawu ze-PML zivame ukungafani nakwezokwelapha kwe-MS. Lokhu akumangalisi ngoba lezi zifo zombili zibangelwa ukudonsa, okusho ukubhujiswa kwento evikelayo ejikeleza izinzwa. Ukulahlekelwa kwalokhu okuvikelayo, okuthiwa i-myelin, kuphazamisa ukudluliselwa kwamasignali kagesi phakathi kobuchopho nomzimba wakho.
Ngenxa yokuthi izimpawu ze-PML kanye ne- MS ephindaphinda zingalingana, kunzima ukukhomba i-PML ezinkathini zokuqala zesifo. Lokho kusho ukuthi ijubane lokuthuthukiswa kwezibonakaliso ezintsha liyisici esisiza ukuhlukanisa ukuthi kungenxa yokuthi i-PML noma i-MS iphinde ibuyele. Izimpawu ze-PML aziveli ngokuzumayo kodwa kunalokho zihlakulele futhi zithuthuke izinsuku ezingaphezu kwamasonto.
Odokotela bangakwazi ukuhlukanisa ngokucacile i-PML esuka ku-MS ngokuhlola ngokucophelela izimpawu zomuntu. Ngenxa yokuthi i-PML yintsholongwane ebusweni bobuchopho, ngokuvamile idala uphawu olungaphezu kwesisodwa noma olubi kakhulu, kanti isibonakaliso esifanayo sinamathuba amaningi okuphindaphindiwe kwe-MS. Noma kunjalo, lokhu kuyisici nje, hhayi umthetho okhuni futhi oqinile.
Enye indlela ebalulekile yokuhlukanisa i-PML ekubuyiseleni kwe-MS ukuhlola isisindo se-MRI somqondo womuntu othintekile.
Njenge-MS, i-PML ibangelwa izilonda zobuchopho ezibonakalayo kwi-MRI, kodwa zivame ukuhlukana nezilonda ze-MS ngendlela evamile, ukuma, indawo, nezinye izici.
Umshini wokugulisa umgogodla ukuhlola uketshezi lwe-cerebrospinal we-JC virus usetshenziselwa ukuqinisekisa ukuxilongwa kwe-PML. Okokugcina, i-biopsy yobuchopho nayo iyenziwa ngezinye izikhathi.
Izwi elivela
Siyaqonda ukuthi ngisho noma kungenzeka ukuthi kungenzeka ukuthi ukuthuthukisa i-PML kuyinkinga enkulu lapho uthatha imithi ethile ye-MS-modified medication. Uma useTysabri, Gilenya, Tecfidera, Ocrevus, noma omunye umuthi wokuzivikela omzimba we-MS futhi uqaphele noma yiziphi izimpawu ezintsha noma ezimbi, xhumana nodokotela wakho ngokushesha.
Nakuba lezi zimpawu azibonisi ngaso sonke isikhathi ukuthuthukiswa kwe-PML, kudingekile ukuthi kutholakale ukuhlolwa kwezempilo okusheshayo ngoba lesi sifo esingavamile sokutheleleka kwengqondo sisongela impilo. Ukuxilongwa kwangaphambili kunikeza ithuba elihle lomphumela omuhle uma kufanele uthuthukise i-PML.
> Imithombo:
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> Greenlee JE. I-Progressive Multifocal Leukoencephalopathy (PML). Ku: Porter RS, Kaplan JL, Lynn RB, et al. I-Merck Manual Professional Version .
> Maas RPPWM, Muller-Hansma AHG, Esselink RAJ, et al. I-Drug-Associated Progressive Multifocal Leukoencephalopathy: I-Clinical, Radiological, ne-Cerebrospinal Fluid Analysis of 326 Amacala. J Neurol . 2016; 263 (10): 2004-2021.
> Inhlangano Kazwelonke Yezinkinga Ezinzima. (2015). I-Progressive Multifocal Leukoencephalopathy.
> Wollebo HS, MK White, Gordon J, Berger JR, Khalili K. Ukuphikelela kanye nePathogenesis ye-Neurotropic Polyomavirus JC. Ann Neurol . 2015 Apreli; 77 (4): 560-570.