Ukuphepha kanye Nalokho Okumele Ukulindelwe Uma Uthatha iTysabri
I-Tysabri yilabo abanezinhlobo zokuvuselela ze-MS futhi ilawulwa njenge-infusion (enikezwe nge-vein yakho kanye kanye nezinsuku ezingu-28). Ngokuvamile kubhalwe iziguli ezingaphenduki kwezinye izifo zokwelapha ezibangelwa isifo se-MS (okusho ukuthi isifo sabo siyaqhubeka sibi kakhulu) noma abangakwazi ukubekezelela ezinye izindlela zokwelapha ze-MS, ngokuvamile ezivela emiphumeleni emibi noma ehluphayo.
Ingozi ye-PML ne-Tysabri
Ingozi enkulu kakhulu (kodwa ehlukumezayo) yokuthatha i-Tysabri yi-PML (i-letifenceal leukoencephalopathy eqhubekayo), okungaba yingozi yokutheleleka ebuchosheni obubangelwa yi-JC virus. Abantu basengozini enkulu yokuthola i-PML uma bethatha ezinye izidakamizwa ezenza buthakathaka amasosha omzimba ngenkathi ithatha iTysabri. Ezinye izinto ezimbili ezibeka ingozi ekwandisa ithuba lomuntu lokuthuthukisa i-PML zibandakanya ukuthatha i-Tysabri iminyaka engaphezu kwengu-2 kanye / noma ukuhlolwa okunamandla kumuntu we-JC virus antibody.
Umuntu ongekho kulezi zici ezintathu eziyingozi, cishe unethuba elingama-1 / 50,000 lokuthuthukisa i-PML ngenkathi ku-Tysabri. Kodwa uma zonke izinto ezintathu zengozi zikhona, ingozi ingaba ngu-11-13 / 1000. Uma umuntu evele evivinya ama-antibody (i-JC virus antibody) (azikho ezinye izici ezingozi) ingozi yokuthuthukisa i-PML ingu-1/1000.
Ukuze unqume ingozi yomuntu yokuthuthukisa i-PML, odokotela bazohlola ukuhlolwa kwegazi ku-antibody ku-JC virus ngaphambi kokumisa i-Tysabri nezinyanga eziyisithupha ngenkathi umuntu ethatha i-Tysabri.
Ngokusekelwe emiphumeleni, udokotela uzobukeza inani leengozi / inzuzo yokuthatha i-Tysabri nesiguli. Ngaphezu kwalokho, odokotela bazothola i-MRI (ukuhlukanisa izimpawu ze-MS esikhathini esizayo ezivela ezingeni elizayo ze- PML izimpawu) ngaphambi kokuqala i-Tysabri.
Ukuqapha i-PML njengoMguli ku-Tysabri
Njengesiguli, uma uthatha i-Tysabri, kubalulekile ukuxhumana nodokotela wakho ngokushesha uma uthuthukisa noma yiziphi izimpawu eziphathelene ne-PML.
Lokhu kungaba yinkimbinkimbi njengoba izimpawu eziningi ze-PML zilinganisa labo be-MS. Izibonelo zezimpawu ze-PML zifaka:
- ubuthakathaka obuthakathaka ohlangothini olulodwa lomzimba
- ukuxuba
- izinguquko zombono
- izinguquko zobuntu
- izinkinga ngokucabanga, inkumbulo, nokuqondisa okuholela ekudidekeni
Okunye Umphumela Ongase Wenzeke Kanye Nezixwayiso Ze-Tysabri
Imiphumela emibi evamile ye-Tysabri ifaka
- ukukhathala
- ikhanda
- ukutheleleka kwe- urinary tract noma uhlelo oluphansi lokuphefumula
- u-vaginitis
- isifuba noma ukuhlukunyezwa kwesisu
- ukucindezeleka
- isifo sohudo
- ukushayeka
- ubuhlungu obukhulu noma ubuhlungu obuhlangene.
I-Tysabri ingabangela nokulimala kwesibindi, okungatholakala ngokuhlolwa kwegazi. Izimpawu zokulimala kwesibindi zihlanganisa ukuphuza kwesikhumba namehlo, ukukhathala okukhulu, ukucwenga, nokuhlanza, noma umchamo omnyama.
I-Tysabri nayo ingabangela ukutheleleka kwe-herpes yobuchopho, intambo yomgogodla, kanye nokukhuluma. Izimpawu zalokhu zihlanganisa umkhuhlane, ikhanda, ukuqina kwentamo, izinkinga zombono, ukudideka, nokuguquka kokuziphatha.
Kube khona amacala okubhekana nokucindezeleka okukhulu ezigulini ezithatha iTysabri, ezinye zidinga ukwelashwa (ngisho nezibhedlela). Izimpawu zalokhu zihlanganisa imifantu / ukuhlambalaza, ukubola, isizungu, ubuhlungu besifuba, ukuqhuma, ukuphefumula ukuphefumula nokucindezelwa kwegazi okuphansi.
Ukwengeza , abantu baseTysabri bangase babe nezinkinga zokutheleleka futhi kufanele bathathe izinyathelo zokuzigwema, kufaka phakathi imikhuba emihle yokugeza izandla nokugwema abantu abagulayo uma kungenzeka.
Ukuqapha ngenkathi ku-Tysabri
I-Tysabri inganikezwa kuphela esikhungweni sokungeniswa esibhalisiwe ngohlelo lwe- "TOUCH". "UKUQHUBA" kusho "Ukuzibophezela kwe-Tysabri: Ukuzibophezela Kwamanye Empilo" futhi uhlelo olubekwe endaweni emzamweni wokubamba noma yiziphi izimo ezenzekayo ze-PML ezinkathini zokuqala, kanye nokuzivimbela.
Ukukhulelwa ku-Tysabri
I-Tysabri ibhekwa ngokuthi "isigaba C sokukhulelwa," okusho ukuthi kubangele ukulimala kumatfusi ezifundweni zesilwane, kodwa umphumela kubantu awungaziwa. I-Tysabri akufanele isetshenziswe ngabesifazane abakhulelwe futhi kufanele imiswe okwesikhashana ngaphambi kokuzama ukukhulelwa (khuluma lokhu nodokotela wakho).
Ngaphansi
Kuzodingeka usebenze eduze nodokotela wakho ukuze unqume ukuthi i-Tysabri imithi efanele yini kuwe. Uma unquma ukuyithatha, qiniseka ukuthi ufunda ilebula lomuthi ngokuningiliziwe. Futhi, qiniseka ukuthi uxoxa ngezibonakaliso nezimpawu ze-PML, ukutheleleka, ukulimala kwesibindi, kanye nokusabela okubangelwa ukwelashwa nodokotela wakho. Qinisekisa ukuthi une-follow-up efanele futhi (isib. Izinyanga ezingu-3 emva kokukhipha ukuqala), nokuthi bonke abanye odokotela bakho bayazi ukuthi uthatha i-Tysabri. A
Imithombo:
Krumbholz, M., et al. (2007). Ukubhekana Nokwelashwa Okulindelekile ku-Natalizumab Ehlanganiswe Nokuqalwa Kwangaphambili Kwe-Neutralizing Antibodies. I-Archives of Neurology , 64: 1331-1333.
I-Polman, CH, et al. (2008). Isivivinyo esilawulwa ngokungahleliwe, esilawulwa yi-placebo sohlobo lwe-natalizumab sokubuyiselwa kwe-multiple sclerosis. I-New England Journal of Medicine , Mar 2; 354 (9): 899-910.
I-National MS Society. (2016). Imishanguzo ye-MS Yokuguqula Imishanguzo .
Rudick, RA, et al. (2006). I-Natalizumab kanye ne-interferon beta-1a yokubuyiselwa kwezifo eziningi. I-New England Journal of Medicine , Mar 2; 354 (9): 911-23.
Ukuphathwa kwe-US nokuDrug. I-Tysabri.
QAPHELA: Ulwazi olukulesi sayithi lunguzinhloso zemfundo kuphela. Akufanele isetshenziswe njengengxenye yokunakekelwa ngumuntu udokotela olayisenisi. Sicela ubheke udokotela wakho ukuze ahlolwe futhi aphathwe noma yiziphi izimpawu noma isimo sezokwelapha .